感光细胞

目的：研究遗传性视网膜变性中感光细胞（photoreceptorcel，PRC）凋亡及其基因调控。

Objective : To investigate photoreceptor cell ( PRC ) apoptosis and gene regulation in hereditary retinal degeneration of Royal College of Surgeon ( RCS ) rats .

光暗条件下，在3种溶液孵育后的感光细胞中都提取到了42kDa的膜结合Gq蛋白α亚基。

After the incubation in three solutions , the membrane-bound Gq α in 42 kDa was all extracted from photoreceptor cell .

遗传性视网膜变性中感光细胞凋亡与Fas和Bcl-2蛋白的表达

Photoreceptor Apoptosis and Fas , Bcl-2 Expression in Inherited Retinal Degeneration

Bcl-2原癌基因可能不参与感光细胞的保护机制。

Bcl-2 protein might not have a role in the regulation of photoreceptor apoptosis .

RCS大鼠感光细胞凋亡与Bcl-2蛋白表达的关系

Photoreceptor apoptosis and bcl-2 expression of RCS rats

RCS大鼠视网膜感光细胞的凋亡

Photoreceptor apoptosis in hereditary degenerative retina of RCS rats

遗传性视网膜变性rd小鼠及其感光细胞凋亡研究

Hereditary retinal dystrophy of rd mice and photoreceptors apoptosis

Caspase-9抑制剂对RCS大鼠感光细胞凋亡抑制作用的研究

Inhibition of photoreceptor apoptosis in RCS rats by caspase-9 inhibitor

目的：探讨介导抗凋亡基因bcl-XL转染视网膜感光细胞的有效方法。

Objective : To investigate an optimal gene transfer method for retinal photoreceptors .

采用HE染色，透射电镜和TUNEL染色方法检测视网膜外核层感光细胞的凋亡过程。

HE staining , transmission electron microscopy and TUNEL were used to detect photoreceptor apoptosis process in outer nuclear layer .

结论RCS大鼠变性过程中视网膜感光细胞层出现视网膜干细胞激活。

Conclusion Endogenous retinal stem cells can be activated in the photoreceptor layer of RCS rat retina during the onset and development of retinitis pigmentosa .

RCS变性大鼠感光细胞凋亡及其视网膜电图与CASPASE-9时空表达的关系研究

Relation between the time - spatiotemporal expression of caspase-9 and photoreceptor apoptosis as well as electroretinography in RCS rats

级光斑示rpe、感光细胞和外核层细胞大量溶解破坏；

With ⅱ grade photic spot , many RPE cells , photoreceptors and cells in outer nuclear layer were lysed and destroyed ;

在玻璃体中，细胞外的CA-1介导了从感光细胞释放的CO2的水合作用，形成碳酸盐。

Extracellular CA-1 mediates the hydration of CO2 released from the photoreceptor cells to bicarbonate within the vitreous .

萝卜硫素对基因变异Tubby小鼠视网膜感光细胞保护作用的研究

Investigated by Sulforaphane in Photoreceptor Cell Survival / Protection in Tubby Mouse

不论缺血还是正常视网膜，均未见S-100免疫反应阳性的节细胞、双极细胞或感光细胞。

No positive immunostaining for S 100 was detected in the ganglion cells bipolar or photoreceptor cells either in ischemic or normal retina .

结果提示：在RCS大鼠视网膜变性的早期，rhEPO对神经元起保护作用，可以使感光细胞得到更多存留；

The results suggest that rhEPO has the therapeutic effect on the early stage of retinal degeneration , which might make more photoreceptors preserved .

抗凋亡基因bcl-XL转染视网膜感光细胞的研究

Transfection of bcl-X_L into retinal photoreceptors in vitro

CRX蛋白可能参与调控与感光细胞有关的基因表达，CRX基因突变会阻断蛋白质在感光细胞核内的传送。

CRX protein can control the expression of the photoreceptor genes .

Gq蛋白是最近几年发现的存在于许多无脊椎动物的感光细胞内的一种G蛋白类型，是由α、β、γ三个亚基组成。

Gq protein is a type of heterotrimeric G protein which is made up of α,β,γ . Gq protein which have been discovered recently exist in many invertebrate photoreceptor cells .

在间接铁锈症的轻度萎缩性视网膜病变中，导致感光细胞形态学改变的重要原因，可能是RPE吞噬功能异常增高。

In indirect siderotic retina with mild atrophy , the morphological change of photoreceptors may mainly be caused by abnormally increasing activity of phagocytic function of RPE .

果蝇的SINA蛋白在眼睛R7感光细胞命运决定过程中起着关键的作用。

SINA protein is critically involved in regulating the cell fate decision of R7 photoreceptor cell in Drosophila eyes .

在斑马鱼中也发现CRX基因，在视网膜的感光细胞和松果体有表达。

CRX gene is also found in the zebrafish , in the retina and apophysis ossium .

目的探讨高压氧治疗对视网膜静脉阻塞（RVO）后视网膜感光细胞层超微结构的影响。

Objective To investigate the effect of hyperbaric oxygen therapy ( HBOT ) for retinal vein occlusion ( RVO ) on ultrastructure of photosensory cell layer .

结果第1组，于注射RA后第16天，视网膜下腔表达视杆细胞特异性标记抗体的视网膜感光细胞数量增多及内核层增厚；

Results In group 1 , the number of the retinal cells expressing rod specific opsin marker in the subretinal space was significantly increased and the thickness of inner nuclear layer was also increased after the RA treatment for 16 days .

Gq蛋白α亚基的移位被认为是控制感光细胞光敏性的重要分子机制之一，在光电传导中起分子开关和信号放大作用。

The translocation of Gq α has been proposed as one of the molecular mechanisms to control photoreceptor sensitivity . Its role is molecular switch and signal amplification in photo-electro transduction .

由于RP患者视力持续性下降的原因是感光细胞的变性和凋亡，而感光细胞不能再生，移植健康的视网膜组织或者细胞，已经成为目前最具前景的治疗策略[1]。

As the reason of unremitting decrease of visual perception in RP is degeneration and apoptosis of photoreceptor cells , which could not be regenerated , transplantation of healthy retina tissue or cells , has become the most perspective treatment strategy currently .

结论急性眼内压升高可能主要对节细胞、内颗粒层（müller细胞）及色素上皮层细胞造成影响，而感光细胞可能不受影响。

Conclusion Acute ocular hypertension maybe influence ganglion cells , pigment epitheliums and the cells in inner nuclear layer ( m ü ller cells ) mainly , but not influence rod and cone cells .

目的：研究CASPASE-9在英国皇家外科学院（RCS）变性大鼠视网膜的时空表达状况与其视网膜电图（ERG）以及感光细胞凋亡的关系，以探讨CASPASE-9在感光细胞凋亡中的作用。

AIM : To investigate the relation between the time - spatiotemporal expression of caspase - 9 and photoreceptor apoptosis as well as electroretinography ( ERG ) in Royal College of Surgeons ( RCS ) rats .

结果显示：（1）RCS大鼠给药组20d，25d，感光细胞的数目与对照组大鼠相比明显增加（P<0.05）；

The results showed that ( 1 ) At postnatal 20 and 25 days , the number of photoreceptor of treatment group was more than that of control group ( P < 0.05 ) .