铅暴露

成年铅暴露史与脑部MRI检测的神经退行性变有关

Past adult lead exposure is linked to neurodegeneration measured by brain MRI

长期铅暴露对儿童海马和额叶~1H磁共振波谱（MRS）的影响

Effects of chronic lead exposure on ~ 1H MRS of hippocampus and frontal lobes in children

维生素B1对低水平铅暴露大鼠的驱铅作用及对钙、锌水平影响的研究

Study Effect of Vitamin B_1 on Lead Excretion in Low-level Lead Exposed Rats and Its Influence on Levels of Calcium and Zinc

铅暴露对大鼠大脑皮质和海马NOS的影响

The Effect of Lead Exposure on NOS in the Rat Hippocampus and Cerebral Cortex

铅暴露对学龄前儿童免疫球蛋白IgE影响的研究

Effect of Lead Exposure on immunoglobulin E In Preschool Children

目的研讨子宫内铅暴露致仔鼠学习能力影响，维生素C、锌和硒对其保护作用。

Objective To evaluate prenatal lead exposure on the offspring 's learning ability and protective effects of some drugs ( zinc , selenite and VitC ) through animal experiments .

结论铅暴露、镁缺乏及智商相对降低均与ADHD的发病有关。

ConclusionLead exposure and magnesium deficit and low IQ contributed to pathogenesis of ADHD .

目的：探讨低水平铅暴露对学龄前儿童免疫球蛋白IgE的影响。

Objective : To study the effects of lead exposure on immunoglobulin E in preschool children .

脑发育不同阶段慢性铅暴露对大鼠在体海马齿状回LTP的影响

Effect of chronic lead exposure at brain different developmental stages

铅暴露与排放对中华鲟幼鱼血液中ALT、AST活力的影响

Effects of lead on activity of ALT and AST in serum of juvenile Chinese sturgeon , Acipenser sinensis

结论子宫内铅暴露损害仔鼠学习记忆能力，维生素C、锌和硒对其智力损害均有保护作用，三者联用，效果较理想。

Conclusion VitC , Zn and Se had protective function against Pb-induced toxicity and can protect lead toxicity on the offspring 's learning ability , which can gain better effect by supplementing them together .

与铅暴露组相比，中剂量和高剂量干预组SOD活力升高，MDA含量降低（P0.05）。

The SOD activity levels in M and H groups were higher , but MDA levels were lower than that in the Pb group ( P0.05 ) .

方法用RT-PCR法检测慢性铅暴露时小鼠海马bcl-2和BAXmRNA表达水平。

Methods RT-PCR techniques were applied to recognize either the mRNA expression of bcl-2 and bax in hippocampus of mice exposed to low level of lead .

主要观察指标：①不同浓度铅暴露对发育期小鼠大脑组织内PKC活性的影响。

MAIN OUTCOME MEASURES : ① effects of Pb exposure in difference concentration on PKC activity in brain tissue of budding mice ;

从实验前两周起至实验时止，以1mg／100g体重／天的剂量分别对铅暴露和对照组给与腹腔注射加兰他敏。

Galantamine were injected i.g at dose of lmg / 100g / day two weeks before experiment .

背景：铅暴露引起的动物学习记忆障碍与脑细胞中蛋白激酶C（proteinkinasec，PKC）活性改变是否有关系呢？

BACKGROUND : Whether plumbum ( Pb ) exposure induced learning and memory disorder in animals is correlated with the changes of the activity of protein kinase C ( PKC ) in the brain tissue ?

铅暴露组和三个干预组小鼠血清、海马组织SOD活力明显降低（P0.05），MDA含量明显升高（P0.05）。

The serum and hippocampal SOD activity levels were significantly decreased in Pb and the three RES interfering groups and MDA levels were increased compared with the C group ( P0.05 ) .

目的观察铅暴露对大鼠海马和大脑皮质一氧化氮合酶（NOS）的影响，探讨铅暴露对中枢神经系统损害的机制。

Objective To study the effect of experimental lead exposure on NOS in the rat hippocampus and cerebral cortex , and explore the neurotoxic mechanism of lead on CNS .

宫内铅暴露降低海马NMDAR-2amRNA表达及影响成年后大鼠海马长时程增强

Effect of lead exposure during pregnancy on hippocampal long-term potentiation and expression of NMDAR-2A mRNA in the off-spring rats

目的：探讨母体慢性铅暴露对子代鼠在体海马齿状回长时程增强（long-termpotentiation，LTP）的影响。

Objective : Our purpose was to investigate the effects of chronic lead exposure of mother rat on long term potentiation ( LTP ) in vivo of their offsprings .

铅暴露者卟啉代谢、血压和ALAD基因多态性的研究

Study on Porphyrin Metablism , Blood Pressure and ALAD Genetic Polymorphism in Lead Exposed Workers

结论孕期铅暴露对仔鼠脑发育的影响与铅引起脑组织MDA含量增高及SOD活力降低有关。

Conclusions The effects of lead exposure of pregnant rats on the brain development of their offspring are associated with the increase of the levels of MDA and decrease of the activity of SOD in the brain .

结论母体铅暴露可损伤仔鼠海马组织NOcGMP途径，这种损伤在停止铅接触一段时间后仍持续存在。

Conclusion Lead exposed in mother can damage the NO / cGMP pathway of pups , and the damage can last a long time after stopping the exposing .

结果显示：小鼠铅暴露后，肝脏GSH水平和TOSC值略有下降；GR、CAT、SOD活性被抑制，在高剂量铅暴露组尤为明显；

The results showed that GSH levels and TOSC decreased slightly , and the activity of GR , SOD and CAT were inhibited , especially in high lead concentration groups .

目的应用金属硫蛋白基因敲除小鼠模型，研究孕鼠铅暴露，新生仔鼠脑组织氧化损伤与金属硫蛋白（MT）间的关系。

Objective To investigate the relationship between the oxidative stress induced by lead during pregnancy and metallothionein ( MT ) in offspring brain using the model of mice with MT gene knocked out .

目的研究环境铅暴露的新婚女性血铅水平对临床受孕时间（TTP）的影响。

Objective To study the effect of environmental lead exposure on time to pregnancy ( time to pregnancy , TTP ) of newly-married women .

HFS后，母体期铅暴露组LTP发生率虽与对照组无显著差异，但其LTP增幅减小，并出现了短时增强转为抑制及LTD型反应。

After the high frequency stimulation ( HFS ), the difference in incidence of LTP induction in control and maternally Pb exposed group was also still non significant .

铅暴露大鼠部分脑区的NMDA受体亚基（NR1、NR2A）表达的研究

Investigation on the Expression of NMDA Receptor Subunit ( NR1 、 NR2A ) in Different Brain Areas of Lead Exposure Rats

母鼠围产期铅暴露对仔鼠不同脑区POU域蛋白表达的影响

Effect of prenatal lead exposure on the expression of POU-domain proteins in different brain regions of rat offsprings

BP神经网络敏感性分析表明，儿童通过饮食、土壤/灰尘、空气以及饮水途径的铅暴露量对IEUBK模型血铅预测值的贡献率分别为55.52%、27.73%、12.80%以及3.95%。

The BP neural network sensitivity analysis indicated that contribution rate were 55.52 % , 27.73 % , 12.80 % as well as 3.95 % to blood lead predicted value , respectively , by the path of diet , soil / dust , air and drinking water .