酪氨酸酶

维生素C对酪氨酸酶催化反应的影响

The effect of vitamin C on tyrosinase catalytic reaction

酪氨酸酶基因表达的磁共振成像（MRI）研究

Monitoring Gene Expression of Tyrosinase Using Magnetic Resonance Imaging

测定了人猿超科中大猩猩、黑猩猩、猩猩和长臂猿酪氨酸酶基因全部5个外显子的DNA序列。

The five e-cons of tyrosinase gene were sequenced for gorilla , chimpanzee , orangutan and gibbon in hominoid .

银杏酸GA1对酪氨酸酶和黑色素瘤细胞的作用

Inhibitory Effect of Ginkgolic Acids GA_1 on Mushroom Tyrosinase and B-16 Cell

Southern杂交实验证实酪氨酸酶基因来源于嗜麦芽假单胞菌。

Southern hybridization studies confirmed that the small fragment cloned in the P.pseudoalcaligenes comes from P.maltophilia DNA .

人酪氨酸酶相关蛋白-2的cDNA克隆及表达

Cloning and expression of human tyrosinase related protein-2 cDNA

方法采用蛋白印迹法检测了酪氨酸酶蛋白和干细胞因子受体kit蛋白含量的变化；

Methods The TRP and KIT protein expression was detected by Western blotting .

8调节酪氨酸酶相关蛋白家族成员的活性，黑素小体中pH值大小以及SH基团的数目。

Control of activity of tyrosinase-related proteins .

正常人MC胞内的黑素小体为弱酸性，pH值在5.5-6.8之间，酪氨酸酶的最适pH值为6.8。

Melanosomes were acidic with pH 5.5-6.8 in normal human melanocyte and the optimal pH for tyrosinase was 6.8 .

三七丹参与慢性缺氧小鼠POD及酪氨酸酶活性

On the Peroxidase and Tyrosinase Activity of a Mouse in a State of Chronic Hypoxia

调和气血中药复方在高中低4个浓度对黑素细胞、黑素合成和酪氨酸酶活性呈显著激活（P＜0.01）。

RP : RP had a strong promotion on melanocytic proliferation , melanin synthesis , and tyrosinase activity at four concentrations comparing with other groups ( P < 0.01 ) .

中药滋补肝肾方对鼠B16黑素瘤细胞酪氨酸酶mRNA表达的调节

Regulation of Tyrosinase mRNA Expression in Mouse Melanoma Cells by Recipe of Traditional Chinese Drugs for Nourishing Liver and Kidndy

白癜风患者血清中抗酪氨酸酶IgM抗体平均滴度为0.238，显著高于正常人对照组0.065（P＜0.001）。

In the case of the two anti-tyrosinase antibodies , patients with active vitiligo had significantly higher titers than those with stable vitiligo ( P < 0.001 );

以恶性黑色素瘤鼠B（16）细胞株和人表皮黑素（MC）细胞作为研究对象，检测壬二酸对B（16）细胞和MC细胞黑素含量和酪氨酸酶（tyrosinase）的影响；

The influence of azelaic acid on melanin synthesis and tyrosinase activity of human melanocytes and murine B_ ( 16 ) melanoma cells were studied ;

苏云金芽孢杆菌酪氨酸酶纯化、性质研究及其mel基因的克隆和表达

Purification of Tyrosinase with Distinct Properties and Cloning , Expression of mel Gene from Bacillus Thuringiensis

酪氨酸酶相关蛋白1（tyrosinaserelatedprotein1，TRP-1）是黑素细胞和恶性黑素瘤细胞中含量最丰富的糖蛋白，其基因是第一个克隆成功的色素基因。

TRP-1 ( tyrosinase related protein 1 , TRP-1 ) or glycoprotein 75 is the most abundant glycoprotein in melanocytes .

糖皮质激素治疗后患者抗酪氨酸酶IgG、IgM抗体滴度均低于治疗前（均P<0.001）。

The sera titers of anti-tyrosinase IgG , IgM antibodies were also higher before glucocorticoid treatment than those after treatment ( P < 0.001 ) .

齐墩果酸也能明显激活酪氨酸酶（P＜0.01），促进黑素合成（P＜0.05），并使黑素细胞TYR和TRP-1mRNA表达量分别比加入无水乙醇的对照增加31.88%和17.73%；

Oleanolic acid also could increase tyrosinase activity and melanogenesis , and compared with its control , the mRNA level of TYR and TRP-1 increased 31.88 % and 17.73 % respectively ;

抗酪氨酸酶IgG、IgM抗体滴度与抗黑素细胞IgM抗体阳性呈正相关（均P<0.001）。

The sera titers of anti-tyrosinase IgG and IgM antibodies were correlated positively with the degree of anti-melanocyte IgM antibody ( P < 0.001 ) .

28味中药酸性成分提取物在高浓度（25mg／ml）时对酪氨酸酶活性均具有抑制作用。

1.28 kinds of crude extracts in high density ( 25mg / Ml ) showed potent inhibitory action on tyrosinase activity .

活动期白癜风患者血清抗酪氨酸酶IgG、IgM抗体滴度明显高于稳定期白癜风患者（均P<0.001）；

The serum anti-tyrosinase IgG , IgM antibodies titer in the active vitiligo patients was significantly higher than that of stable vitiligo patients ( P < 0.001 );

目的：用反义核酸技术抑制小鼠B16黑色素瘤细胞酪氨酸酶基因（tyr）的表达。

AIM : To inhibit the expression of tyrosinase gene in murine B16 melanoma cells by antisense nucleotide .

从马铃薯中分离纯化出酪氨酸酶（Tyrosinase，EC.1.14.18.1），并对其理化性质进行了研究。

Tyrosinase ( EC . 1 . 14.18.1 ) was isolated and purified from potato and its biochemical properties was studied .

酚氧化酶（phenoloxidase，简称PO，EC1.14.18.1，在哺乳动物中也称为酪氨酸酶）是昆虫生命过程中的重要调节酶。

Phenol oxidase ( PO , EC 1.14.18.1 , and was also known as tyrosinase in mammalian ) is one of the key enzymes in the development of insects .

目的探讨氢化可的松体外对酪氨酸酶活性影响，以及对小鼠B16黑素瘤细胞株细胞增殖、黑素合成以及细胞内酪氨酸酶活性的作用。

AIM To study the effect of Hydrocortisone injection on tyrosinase activity and the melanogenesis of B 16 murine melanoma cell .

酪氨酸酶（TYR）是一种含铜酶，是黑素代谢和儿茶酚胺合成的关键酶。

Tyrosinase , a copper-containing enzyme , . plays a key role in melanin metabolism and catecholamine synthesis .

4种美白剂对B-16细胞内酪氨酸酶活性抑制的研究

Inhibitory Activity of Four Lighteners Against Tyrosinase in B-16 cells

测定壬二酸对人表皮黑素细胞和鼠黑色素瘤B16细胞酪氨酸酶活性及黑素含量变化观察壬二酸的脱色素作用。

The influence of azelaic acid on melanin synthesis and tyrosinase activity of human melanocytes and murine B16 melanoma cells were studied .

体外培养的RPE细胞未检测到酪氨酸酶RNA表达，故随着细胞分裂增殖，色素颗粒逐渐减少，提示体内外RPE细胞在功能上存在某些差异。

There is no expression of tyrosinase in RPE cells cultured in vitro indicates that their function , to some extent , is different with those in vivo .

结果：①白癜风患者血清抗酪氨酸酶IgG抗体平均滴度为0.316，显著高于正常对照组0.082（P<0.001）；

Results : The mean sera titer of anti-tyrosinase IgG antibody in the patients with vitiligo was 0.316 which was significantly higher than that of the healthy controls ( P < 0.001 );