过氧桥

双氢青蒿素（DHA）是一种青蒿素类药物中活性较强的衍生物，是由青蒿素经四氢硼钠还原而成[1]，具有独特的过氧桥结构。

Dihydroartemisinin ( DHA ) is a strongly active artemisinin-based medicine in the all derivatives , which is returns to original state by artemisinin after four hydrogen boron sodium becomes , has the unique peroxide bridge structure .

结果过氧桥键是青蒿素类化合物的活性中心，在Fe2+影响下过氧键逐渐裂解，两个氧原子与Fe2+以共价键结合形成环状加成产物。

Results The peroxide bridge is the active center of QHS and induced by ferrous iron to produce cyclic product .

目的：青蒿素类抗疟药是一类具有内过氧桥结构的倍半萜内酯类化合物。

Objective : Artemisinin derivatives are a kind of sesquiterpene lactone with endoperoxide bridge .

一般认为，青蒿素类药物的作用机制与其结构中的内过氧桥有关，最近又提出一些与以往不同的观点。

It is generally agreed that artemisinins action mechanism is associated with the endoperoxide function , but some researchers have some other ideas .

青蒿素是从青蒿植株地上部分提取的一种含有过氧桥结构的倍半帖内酯化合物，是目前最有效的抗疟药物，市场需求量巨大。

Artemisinin , a sesquiterpene lactone endoperoxide derived from the acrial part of the plant A. annua , is the most effective anti-malarial drug .