过敏性疾病

特异性IgE检测在过敏性疾病诊断中的应用

The application of the specific IgE detected in the diagnosis of the allergic disease

目的比较血清sIgE与抗原皮试在过敏性疾病患者的临床应用价值。

Objective To investigate the clinical value of serum sIgE and allergen skin test in allergic disease .

过敏性疾病在全球仍然是一个难以攻克的难题，因为它的发病机制尚不清楚，目前的治疗方法不能延缓疾病的进展。

It is still a global challenge because the pathogenesis is unclear and current treatments cannot delay progression of the disease .

Tim基因家族及其与自身免疫性疾病和过敏性疾病的关系

Relationship between the TIM Gene Family and with Autoimmune and Allergic Diseases

茶苯海明为一种组胺H1受体拮抗剂，主要用于抗晕动，也用于过敏性疾病，如枯草热、荨麻疹。

Dimenhydrinate ( DMH ), a histamine H_1-receptor antagonist , is widely used in the treatment of giddy , irritability , pollenosis and urticaria .

应用非条件Logistic回归模型分析食物耐受形成的预测因素及其他过敏性疾病发生的影响因素。

The predictors of food tolerances and influential factors of other allergic diseases were analyzed by unconditional Logistic regression models .

100例过敏性疾病患者血清特异性IgE与皮试的相关性研究

Study on the relationship between serum sIgE and allergic skin test among 100 cases allergic disease

脐血IL-10和IgE水平与婴幼儿过敏性疾病的关系

The Relationship between the Levels of IL-10 and IgE in Newborn Cord Blood and the Development of Infant Allergic Diseases

一般认为，IgE及其高亲和力受体FcεRI是导致过敏性疾病的关键分子。

It is well known that IgE and its high affinity receptor Fc ε RI are key molecules in triggering allergic diseases .

目的评价类胰蛋白酶（tryptase）测定在过敏性疾病诊断中的应用。

Objective To evaluate the use of tryptase in diagnosing allergic diseases .

目的探讨患过敏性疾病的婴幼儿在出生时脐血IL-10、IL-4、IgE的变化及三者之间的关系。

Objective To evaluate the changes and relationship of newborn cord blood IgE , IL-4 , IL-10 in infants with allergic diseases .

采用国际儿童哮喘与过敏性疾病研究第一阶段问卷的核心问题进行问卷调查。吸烟状况（包括家庭吸烟人数、吸烟成员及家庭吸烟量）与儿童哮喘关系分别按家族史在Logistic回归模型中进行分析。

Association of smoking condition ( including number of smokers , concrete smoking members and daily consumed cigarettes ) and childhood asthma was analyzed in logistic regression models by family history respectively .

过敏性疾病患儿的IL10及IgE之间存在明显的相关性。

There is a significant negative correlation between IL 10 and IgE in infants with allergic diseases .

脐血lgE水平、PPD皮试反应与小儿过敏性疾病

Relationship between umbilical serum IgE level as well as PPD skin test and anaphylactic diseases in children

各种过敏性疾病中过敏性鼻炎sIgE阳性检出率最高，其次是哮喘和过敏性咳嗽；

Among all the allergic diseases , the positive ratio of sIgE was highest wan allergic rhinitis , the second was asthma and then allergic cough .

Marshall博士及其同事发现打鼾的风险因素与过敏性疾病的风险因素类似。

Marshall of the Woolcock Institute for Medical Research in Sydney and his associates found that risk factors for snoring were very similar to those for allergic disorders .

目的探讨组胺H1和H2受体拮抗剂联合使用治疗Ⅰ型过敏性疾病的可行性。

Objective To study the feasibility of the co adminstration of histamine H 1 and H 2 receptor antagonists in the treatment of type ⅰ allergic diseases .

血浆BNP检测在慢性心衰诊断及治疗中的应用过敏性疾病吸入组变应原检测及脱敏治疗分析

To investigate the value of level of plasma BNP in diagnosis and treatment of congestive heart failure Allergen Detection of Chronic Anaphylactic Diseases and Analysis of Desensitization Treatment

目的建立流式细胞术（FCM）分析嗜碱性粒细胞活化试验（BAT）的方法并评估其在过敏性疾病诊断中的意义。

Objective To establish the method for analysing basophil activation test ( BAT ) by flow cytometry ( FCM ) and evaluate its clinical significance in the diagnosis of allergic disease .

在分析IgE分子功能表位的基础上进行适当的分子设计可获得潜在的治疗过敏性疾病的拮抗剂如抗IgE抗体类似多肽、IgE类似肽以及其他抑制性小分子等。

Molecular design based on the functional epitope analysis of IgE could obtain potential antagonists of allergic diseases such as peptides derived from anti-IgE antibodies , IgE structural analogous peptides and suchlike molecules .

结论：出生时脐血IL10降低和IgE增高与婴幼儿过敏性疾病的发生关系密切。

Conclusions : The increase of cord blood IgE and the decrease of IL 10 are significantly related to the development of infant allergic diseases .

我们的研究将有助于更好的阐述IL-5基因转录调控的特异机制，并为IL-5相关的过敏性疾病的治疗提供了重要的理论基础。

These data will contribute to elucidating the unique mechanisms of IL-5 transcriptional control , which is crucial to the development of new therapeutic strategies for IL-5-related allergic diseases .

发现儿童与老人发病率低，病人的过敏性疾病史和药物过敏史、原有的肝病及感染性疾病都与DA的发生显著相关。

Our results showed that incidence of drug allergy was low in children and the aged persons . The history of allergy , the presence of liver damage and infectious diseases were all related to the development of drug allergy .

流行病学调查显示对结核菌的迟发相变态反应强度与过敏性疾病发生成负相关[1]，此后很多研究也支持这一结论，同时大量动物实验证实BCG对变应性哮喘小鼠具有保护作用。

Clinical investigations demonstrate that there was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy , afterwards lots of studies support this view , many animal experiments demonstrate the protective effects of BCG on asthmatic mouse models .

方法：选择632例临床诊断为过敏性疾病的患者，用野苋菜花粉及春、夏、秋、冬四季花粉的提取液做皮试，并测定其总免疫球蛋白E（IgE）。

METHODS : The intradermal test was performed on 632 allergic patients , who were diagnosed clinically with the extract of amaranthaceae pollen and mixed extracts of spring , summer , autumn and winter pollens respectively , and their total serum immunoglobulin E ( IgE ) was determined .

IL-18对于清除细胞内细菌、真菌和原生动物尤其有效。多项研究提示，IL-18参与自身免疫性疾病、慢性炎症和过敏性疾病病程；

In particular , the clearance of intracellular bacteria , fungi and protozoa requires the induction of host-derived IFN - γ by IL-18 . Involvement in the progression of pathogenicity in autoimmune diseases , chronic inflammatory diseases and allergic diseases was reported .

方法采用酶免疫分析法对468例过敏性疾病患者血清过敏源特异性IgE抗体进行定性检测，并给予仅对尘螨过敏的患者粉尘螨注射液脱敏治疗。

Methods The specific IgE for food and inhalant allergens were detected serologically by ELISA in the sera from 468 cases with the hypersensitive disease . The dermatophagoides farinae injection was used to desensitize the patients who were sensitive only to dust ( powder ) mite .

血小板中环氧酶和脂氧酶作用于花生四烯酸代谢系统，可产生形成血栓的血栓烷A2（TXA2）及引起过敏性疾病的12－羟基二十碳四烯酸（12－HETE）。

In platelets , cyclooxygenase and lipoxygenase catalyze the initial reactions for the formation of two major arachidonic acid metabolites , thromboxane B 2 ( TXB 2 ), 12 hydroxy 5,8,10,14 eicosatetraenoic acid ( 12HETE ) .

近年来，随着临床治疗应用的单克隆抗体（mAb）的数量显着增加，其中特别是治疗癌症，自身免疫性疾病，过敏性疾病，移植和抗独特型疫苗等单克隆抗体。

Currently many monoclonal antibodys ( mAb ) used in clinical trials and approved for the treatment are increasing significantly in recent years . They are used for the treatment of cancer , autoimmune diseases , allergic diseases , transplantation , and anti-idiotype vaccine .

近年来，免疫细胞的效应&调节功能失衡亦成为过敏性疾病研究中的重要内容，调节性T细胞（Treg）亚群的调节功能不足，可能是哮喘等变应性疾病发生的重要机制。

In recent years , disbalance of immunocyte effection-regulation function has become a key subject of allegic diseases study . Deficient of regulatory T cell ( Treg ) subset regulating function may be the key mechanism of allegic diseases such as asthma .