蛋白质一级结构

提出了蛋白质一级结构和功能关系的定量分析方法。

A quantitative analysis method for the determination of primary protein structure and function relation was proposed .

Fuzzy聚类分析在蛋白质一级结构分类中的应用

Application of fuzzy assemble analysis in CLASSI-FICATION of protein primary structure

它是目前上百种已知蛋白质一级结构的磷脂酶A2中碱性最强的蛋白，氨基酸组成中碱性氨基酸较丰富。

The PLA2 is the most basic protein among one hundred different PLA2s which protein primary structure were known ;

并与其它一些动物PLA2的结构进行比较。结果：成功获得了该磷脂酶A2的cDNA和蛋白质一级结构。

Comparing the primary structure with some others PLA2 structure Results : cDNA and protein primary structure of rabbit type PLA2 were obtained sucessfully ;

结果发现，脊椎动物的胰岛素蛋白质一级结构（A链和B链）和mRNA非常相似，但部分动物C肽的部分序列有差异；

The results indicate that the insulin ( A chain and B chain ) primary protein sequences and mRNA of vertebrate are quite similar . But C peptide of some animals show some differences in part of amino acid sequences .

Anfinsen等人的研究工作表明，给定蛋白质一级结构序列，利用理论计算对蛋白质结构进行预测是一个可行的方法。

According to the research of Anfinsen et al , predicting the native structure of a protein from its amino acid sequence by using theoretical computing method is a feasible approach .

一种运用灰色预测模型预测蛋白质一级结构的方法

A Method for Primary Structure of Protein Prediction by Applying Gray Forecasting Model

计算实验表明蛋白质一级结构包含着四级结构信息。

Computational experiments have shown that protein primary sequence contains quaternary structure information .

这可能是公认的蛋白质一级结构决定三级结构规则的一种表现。

This may be a manifestation of the recognized rule that primary structure of protein determine the tertiary structure .

本文用支持向量机方法从蛋白质一级结构出发区分同源二聚体、同源三聚体、同源四聚体和同源六聚体。

Support vector machine approach is applied to classifying the homodimers , homotrimers , homotetramers and homohexamers from the primary structure .

与此同时各种蛋白质一级结构，即多肽链的氨基酸残基的排列顺序也在不断被探测出来。

At the same time , many protein structures which are the peptide chain of amino acid sequences have also been detected .

围绕蛛丝蛋白展开的研究将有助于揭示蛋白质一级结构、蛋白质分子折叠与蛋白质大分子特性之间的内在联系。

Research efforts on spider silk proteins are helping to reveal the relationships among protein sequence , protein assembly and protein macromolecular properties .

根据蛋白质一级结构原理，选用了一种碱性蛋白质&鱼精蛋白，研究了牛乳蛋白胶粒在适口酸性条件下的稳定性问题。

Using the theory of protein primary structure , protamine was chosen to increase the stability of milk protein in the dainty acidic condition .

从密码学的观点研究了遗传信息从核酸流向氨基酸和从蛋白质一级结构流向三级结构的信息传输问题。

The transmission of genetic information from nucleic acid to aminoacid sequence and from primary structure to tertiary structure of protein are dis-cussed from the point of cryptography .

并由此给出蛋白质一级结构序列的核心词词典，并由此讨论数据库的复杂性问题、同源蛋白质的分类、预测与比对等问题。

We obtain a dictionary of kernel words for primary structure sequence of protein , and consider the nolinear complexity problem of protein and database , classi ? cation , prediction and alignment problem of homologous proteins .

其中，因丝氨酸蛋白酶抑制剂分布广泛，种类繁多，在蛋白质一级结构、作用机理、氨基酸组成以及生物活性等方面有较为深入的研究。蛋白酶抑制剂是一类广泛存在于植物中的蛋白质。

Among these serine proteinase inhibitors are most extensively studied in the primary structure , the composition of amino acid , their interactions with serine proteinase and possible biological roles . Proteinase inhibitors are proteins widely distributed in plants .

而后将新的编码方法和其他编码方法在相同的实验条件下进行训练建模预测，实验结果表明新的编码方法更加充分利用了蛋白质一级结构信息，比较适合非同源或低同源蛋白质结构预测。

Then we used different code schemes to do the prediction . The results shows that the new coding scheme make full use of the protein level structure information and is more suitable for non-homologous or lower homologous protein structure prediction .

多肽/蛋白质一级结构即氨基酸序列决定其结构与功能，且高级结构甚难测定，因此在多肽/蛋白质结构与功能预测时，直接基于氨基酸序列提取特征更具实际应用价值。

Amino acid sequence of peptide / protein determines its structure and function , senior structure is very difficult to get . So when predicting peptide / protein structure and function , characteristics are extracted directly based on amino acid sequence .

目的：确定具强杀菌活性的兔Ⅱ型磷脂酶A2（PLA2）cDNA和蛋白质的一级结构，了解其杀菌功能与蛋白质一级结构的关系。

Objective : To determine cDNA and protein primary structure of rabbit type PLA2 with potent bactericidal activity , and to understand the relationship of bactericidal function and protein primary structure Methods : Cloning cDNA of rabbit type PLA2 from bone marrow cDNA library by PCR and determining DNA sequence ;

该模型的最大特点在于直接通过蛋白质的一级结构预测蛋白质之间的相互作用，改进后的模型较原模型更加适合于蛋白质相互作用的预测。

The new model is more suitable for the prediction of the protein-protein interaction .

认识蛋白质的一级结构，对于了解蛋白质的结构与功能的关系以及蛋白质结构的预测等，都具有十分重要的意义。

Investigating the primary sequence has very important meaning on understanding the relationship between the primary and tertiary structure and also plays a significant role in the structure prediction .

蛋白质的一种二级结构，相对平坦，在两条平行的或反向平行的肽段之间形成氢键。

A secondary structure in proteins , relatively flat and formed hydrogen bonding between two parallel or anti-parallel stretches of polypeptide .

蛋白质的折叠问题就是通过蛋白质的一级结构来预测蛋白质的三维结构。

The problem of protein folding is to predict the protein three-dimensional structure from its one-dimensional structure .

蛋白质折叠热力学假说中明确指出蛋白质一级结构可以完全决定其空间构型，天然结构下的蛋白质的自由能是全局最小值。

The protein folding thermodynamic hypothesis point out that the spatial structure of a protein is encoded by its primary structure , and its unique spatial structure is the conformation with minimal free energy .

结构蛋白质组学是指对上述全部蛋白质一级和三维结构的测定。

Structural Proteomics refer to determine the first level and 3D structure of all-above metioned proteins .

蛋白质分子关于其折叠方式的信息又蕴藏在其氨基酸序列或一级结构中，因此从蛋白质的一级结构来预测高级结构就成为了蛋白质研究领域的一个重要任务。

So , the structure prediction from the primary structure to advanced structure becomes an important task in the protein research field .

自从安芬森的蛋白质变性-复性试验以后，越来越多的人接受了蛋白质的一级结构决定了这个蛋白质的三级结构的假定。

Since Anfinsen experiment , more and more people accepted the assumption that the primary structure of protein determines the tertiary structure of this protein .

与其他蛋白质二级结构预测的方法进行了比较，结果表明，该方法能充分利用蛋白质的一级结构信息，获得了很好的预测效果。

Compared with other encoding methods , the method has better results using protein primary structure information .

蛋白质折叠问题是当前生物信息技术研究的核心问题之一，它所要解决的是蛋白质一级结构中的氨基酸序列如何折叠成三维空间结构的问题。

Protein folding problem is one of the core research areas in bioinformatics , and describes how an amino acid sequence folds into a specific spatial protein .