胸苷酸

DNA甲基化转移酶抑制剂与胸苷酸合成酶抑制剂体外联合用药的抗肿瘤增效作用

Synergistic Anticancer Effect of DNA Methyltransferase Inhibitor Combined with Thymidylate Synthase Inhibitor in vitro

运用mRNA体外展示技术筛选胸苷酸合成酶RNA亲和肽

Identification of Peptides That Bind With Thymidylate Synthase RNA Using mRNA Display Technique

胸苷酸合成酶mRNA和二氢嘧啶脱氢酶mRNA在结直肠癌中的表达及临床意义

The mRNA expressions and the clinical significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal carcinoma

背景与目的：胸苷酸合成酶（ThymidylateSynthase，TS）是DNA合成的关键酶。

BACKGROUND & OBJECTIVE : Thymidylate synthase ( TS ) is a key enzyme in DNA synthesis .

方法：采用3H胸苷酸（3HTDR）掺入法检测了20例HRPC细胞对常用化疗药物的敏感性。

Methods : Using 3H TdR method to study the chemosensitivity to six chemical drugs in 20 cases of HRPC .

目的探讨胸苷酸磷酸化酶（TP）在宫颈上皮内瘤变（CINⅠ、Ⅱ、Ⅲ）及宫颈癌发生、发展中的作用及与预后的关系。

Objective To investigate the role of thymidine phosphorylase ( TP ) and its prognostic significance in cervical intraepithelial neoplasia ( CIN ⅰ、ⅱ、ⅲ) and cervical carcinoma .

目的探讨乳腺癌组织中胸苷酸化酶（TP）、胸苷酸合成酶（TS）和二氢嘧啶脱氢酶（DPD）mRNA表达水平及其与预后的关系。

Objective To study the expression of thymidine phosphorylase ( TP ), thymidylate synthase ( TS ) and dihydropyrimidine dehydrogenase ( DPD ) mRNA in breast cancer and its correlation with prognosis .

目的检测原发性胃癌、结直肠癌胸苷酸合成酶（TS）启动基因增强子区段（TSER）的多态性。

Objective To detect the polymorphism int he thymidylate synthase promoter enhancer region ( TSER ) in primary gastrointestinal cancer .

胸苷酸合成酶、胸腺嘧啶脱氧核苷磷酸化酶及二氟嘧啶脱氢酶的表达与乳腺癌预后的相关性目的：检测北欧和中国人乳癌患者TP、TS、DPDmRNA水平的差异。

Aim : To investigate the difference between the mRNA levels of thymidine phosphorylase ( TP ), thymidylate synthase ( TS ), and dihydropyrimidine dehydrogenase ( DPD ) between Chinese and North European breast cancer patients .

另外，通过高效液相法（HPLC）检测细胞内液的药物含量、免疫组化法检测胸苷酸合酶（TS）的表达、化学法检测NO含量等研究其抗耐药作用机制。

The concentration-time course of 5-Fu-GCL in intracellular fluid was detected with high performance liquid chromatography ( HPLC ) . Thymidylic acid synthase ( TS ) expression was observed with immunohistochemical method , and NO content was determined with chemical method .

洛拉曲克是一种新型胸苷酸合酶（ThymidylateSynthase，TS）抑制剂，脂溶性且不含谷氨酸侧链，有利于细胞摄取，从而提高肿瘤细胞的洛拉曲克的浓度。

Nolatrexed is a novel thymidylate synthase ( Thymidylate synthase , TS ) inhibitor , which is fat-soluble and do not contain glutamic acid side-chain and be easily cellular uptake , thereby increasing the concentration in tumor cells .

目的探讨氟尿嘧啶类药物代谢酶&胸苷酸合成酶（TS）、胸苷磷酸化酶（TP）和二氢嘧啶脱氢酶（DPD）表达水平与人胃肠道肿瘤细胞化疗敏感性的关系。

Objective To probe the relationship between the chemosensitivity of 7 gastrointestinal cancer cell lines and the expression levels of metabolic enzymes of fluoropyrimidines including thymidylate synthase ( TS ), thymidine phosphorylase ( TP ), and dihydropyrimidine dehydrogenase ( DPD ) .

目的：研究胸苷酸合成酶（TS）基因3′-UTR多态性与胃癌对5-FU化疗敏感性的关系。

Objective : To investigate the relationship between polymorphism in the 3 ′ - untranslated region ( 3 ′ - UTR ) of thymidylate synthase gene ( TS ) and sensitivity of stomach cancer ( SC ) to fluoropymidine ( 5-FU ) - based chemotherapy .

TS是合成胸苷酸的限速酶，催化dUMP转化为dTMP，而dTMP是DNA合成和修复所必须的胸腺嘧啶核苷酸的唯一来源，所以TS在细胞增生过程中发挥重要作用。

TS is a rate-limiting enzyme in the synthesis of the thymidine and converts dUMP into dTMP , the only source of thymidine for DNA synthesis and repair . Thus , TS plays an important role in the cell division and proliferation .

为临床选择激素难治性前列腺癌（HRPC）的化疗方案提供参考，采用3H-胸苷酸（3H-TdR）掺入法检测了20例HRPC细胞对常用化疗药物的敏感性。

To give reference to clinical chemotherapy scheme of hormone refractory prostate cancer ( HRPC ), 3H-TdR method was used to study the chemosensitivity to six chemical drugs in 20 cases of HRPC .

背景与目的：5-Fluorouracil（5-FU）主要通过抑制胸苷酸合成酶发挥抗癌作用，而二氢嘧啶脱氢酶是5-FU体内代谢的一个起始酶和限速酶。

BACKGROUND & OBJECTIVE : Anti cancer effect of 5 Fluorouracil ( 5 FU ) is mediated mainly by inhibition of the thymidylate synthase ( TS ), while dihydropyrimidine dehydrogenase ( DPD ) is an initial and a rate limiting catabolic enzyme of 5 FU .

目的探讨胸苷酸合成酶（TS）、拓扑异构酶1（Topo1）和肿瘤增殖指标Ki67对伊立替康（CPT11）联合5氟脲嘧啶（5Fu）治疗晚期大肠癌患者的临床疗效和预后的预测价值。

Objective To investigate the prognostic value of thymidylate synthase ( TS ), topoisomerase-1 ( Topo-1 ), and proliferating index Ki-67 in advanced colorectal cancer patients on irinotecan ( CPT-11 ) in combination with fluorouracil treatment ( 5-Fu ) .

本文采用Okamura氏的寡聚脱氧胸苷酸（oligo-dT）-纤维素柱层析法分离纯化小牛胸腺末端脱氧核苷酸转移酶（TdT）。

Present paper used Okamura 's method of oligo dT-cellulose affinity chromato - . graphy to isolate and purify terminal deoxynucleotidyltransferase ( TdT ) from calf thymus . The procedure consists of : extraction of crude enzyme ;

胸苷酸合成酶和谷胱甘肽-S-转移酶在食管癌及其他肿瘤中的应用

Application of TS and GST in esophageal cancer and other tumors

胸苷酸合成酶的表达及其与子宫内膜癌的相关性研究

Expression of Thymidylate Synthase and Its Relationship with Endometrial Carcinoma

胸苷酸合成酶在膀胱癌组织中的表达及意义

Significance of Expression of Thymidylate Synthase in Bladder Cancer

宫颈上皮内瘤变及宫颈癌胸苷酸磷酸化酶表达

The Expression and Significance of TP in Cervical Intraepithelial Neoplasia and Cervical Carcinoma

胸苷酸合成酶预测胃癌化疗敏感性的研究

The Study of Thymidylate Synthase Predication to Efficacy of Chemotherapy in Gastric Carcinoma

胸苷酸合成酶表达调控的分子机制

Molecular Mechanisms Regulating the Expression of Thymidylate Synthase

洛拉曲克对胸苷酸合成酶蛋白质表达水平的动态影响

Effects of nolatrexed on thymidylate synthase protein expression

胸苷酸合成酶基因多态性及其蛋白表达与食管鳞状细胞癌淋巴结转移的关系

Polymorphisms of Thymidylate Synthase Gene and Correlation of Its Protein Expression to Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma

因此，胸苷酸合成酶是肿瘤化学治疗的热门靶点，其抑制剂是抗肿瘤药物研究的重要方向。

Consequently , TS is a hot target in cancer chemotherapy , Inhibitor of TS is an important direction of anticancer research .

应用变性高效液相色谱技术建立胸苷酸合成酶基因多态检测平台

Simultaneous detection of polymorphisms in the 3 ' - and 5 ' - UTR of thymidylate synthase gene using denaturing high-performance liquid chromatography

新型胸苷酸合成酶抑制剂洛拉曲克抗增殖作用的差异及其机理的研究维甲酸及其海藻酸钠微球抗增殖作用的实验研究

Study of the Difference in Anti-proliferative Potency of a New Thymidylate Synthase Inhibitor Nolatrexed and Its Mechanism The Experiment Research of the Restrain Effects of Retinoic Acid and Its Alginate Sodium Microspheres on Proliferation