胆汁淤积症

目的探讨一氧化氮（NO）与妊娠肝内胆汁淤积症（ICP）病理生理变化之间的关系。

Objective To study the relationship of serum nitric oxide ( NO ) level with pathophysiological changes in intrahepatic cholestasis of pregnancy ( ICP ) .

【目的】妊娠期肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）是妊娠期特有的疾病，对胎儿危害极大，其病因和发病机制尚不明确。

[ Objective ] Intrahepatic cholestasis of pregnancy ( ICP ) is a disease that occurs during the second half of pregnancy and does great harm to the fetus .

维生素K1预防妊娠期肝内胆汁淤积症产后出血

The role of vitamin K _1 in prevention of postpartum hemorrhage of intrahepatic cholestasis of pregnancy

人类白细胞抗原G、E在人胎盘组织的表达及其与妊娠期肝内胆汁淤积症的关系

Expression of Human Leucocyte Antigen G and E in Human Placenta and Their Relationship with Intrahepatic Cholestasis of Pregnancy

目的评估联合治疗重度妊娠期肝内胆汁淤积症（ICP）临床疗效。

Objective To evaluate efficacy of the combined treatment for severe intrahepatic cholestasis of pregnancy ( ICP ) .

探讨妊娠期肝内胆汁淤积症（ICP）患者的新生儿脐动脉血气的特点及缺氧、酸中毒的情况。

To analyse the results of ICP neonatal umbilical artery blood gases and study neonate hypoxia and acidosis .

妊娠肝内胆汁淤积症血清E3、β-hCG与胎盘ER、HCG表达的研究

Study of serum Estriol , β - hCG and expression of the estrogen receptors , HCG on placenta in intrahepatic cholestasis of pregnancy

目的探索妊娠期肝内胆汁淤积症（ICP）与孕产妇及其子代健康的关系。

Objective To determine the relationship of intrahepatic cholestasis of pregnancy ( ICP ) to maternal and child health .

目的：评价产科干预对妊娠期肝内胆汁淤积症（ICP）妊娠结局和新生儿结局的影响。

Objective : To appraise the influence on pregnancy outcome and neonatal outcome of ICP after adequate obstetric intervention .

血清TBA、ALP联合测定在妊娠期肝内胆汁淤积症诊断中的意义

Clinical Significance of Detection of Serum TBA and ALP in Diagnosis of Intrahepatic Cholestasis of Pregnancy

目的探讨雌激素受体α（ERα）基因多态性与妊娠肝内胆汁淤积症（ICP）发病的关系。

Objective To investigate the relationship between estrogen receptor alpha ( ER α) gene polymorphism and intrahepatic cholestasis of pregnancy ( ICP ) .

目的研究分析妊娠期肝内胆汁淤积症（ICP）患者肝功能指标与ICP围产儿预后关系。

Objective To analyse the relationship between hepatic function index and perinatal-prognosis in patients with the intrahepatic cholestasis of pregnancy ( ICP ) .

目的探讨有效治疗及适时终止妊娠对妊娠期肝内胆汁淤积症（ICP）围生结局的影响。

Objective To explore the effective treatment and timely termination of pregnancy on the intrahepatic cholestasis of pregnancy ( ICP ) of perinatal outcome .

目的探讨无刺激试验（NST）及B超检查胎儿生物物理评分（BPS）对妊娠肝内胆汁淤积症（ICP）孕妇胎儿宫内安危监测的临床价值。

Aim To investigate the clinical value of NST and BPS on fetal safety of pregnancy with ICP .

目的检测妊娠期肝内胆汁淤积症（ICP）患者产前及产后血清瘦素水平，以探讨瘦素与ICP的关系。

Objective To investigate the relationship between leptin and intrahepatic cholestasis of pregnancy ( ICP ) by measuring the serum leptin before and after delivery .

急性肝内胆汁淤积症（AIC）不仅临床少见，而且诊断和治疗方面都比较困难。

Acute intrahepatic cholestasis ( AIC ) is not often seen in clinic and is difficultly diagnosed and treated .

目的：探讨脐动脉血流速度测定及无负荷试验评估妊娠期肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）患者围生儿预后的应用价值。

Objective : To study the value of umbilical artery flow velocity and nonstress test ( NST ) for patients with intrahepatic cholestasis in pregnancy ( ICP ) .

目的研究地塞米松治疗妊娠肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）的疗效，观察地塞米松对胎鼠垂体-肾上腺的影响。

Objective To evaluate the effects of dexamethasone on pregnant rats with intrahepatic cholestasis of pregnancy ( ICP ) and the influence of desamethasone on the fetal pituitary-adrenal function .

目的探讨细胞凋亡因子Caspases（半胱天冬氨酸蛋白酶）增加是否与妊娠期肝内胆汁淤积症（ICP）的发病具有相关性。

Objective : To explore whether the up-regulation of Caspases is correlated with the mechanism of Intrahepatic Cholestasis of Pregnancy ( ICP ) .

目的：探讨妊娠合并肝内胆汁淤积症（ICP）孕妇、新生儿血清胆汁酸（CA）含量与胎儿宫内窘迫的关系；ICP与新生儿黄疸的关系。

Objective : To explore the relationship between intrahepatic cholestasis of pregnancy ( ICP ), serum cholic acid ( CA ) content in mother and infants and fetal distress and neonates ' icterus .

妊娠期肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）也称产科胆汁淤积症，以瘙痒和黄疸为主要临床症状，伴血生化异常，如血清胆汁酸升高，肝酶升高等。

Intrahepatic cholestasis of pregnancy ( ICP ), also called obstetric cholestasis , is a disorder characterized clinically by pruritus , icterus , or both , biochemical disturbances in liver enzymes .

妊娠肝内胆汁淤积症（ICP）往往在妊娠晚期发生胎儿猝死，但机制尚不清楚。

Fetal sudden death is often found in pregnant women with Intrahepatic Cholestasis of Pregnancy ( ICP ) in late trimester , and the mechanism of fetal sudden death is still unknown .

目的探讨熊去氧胆酸（ursodeoxycholicacid，UDCA）的应用对胆汁淤积症（ICP）孕鼠脏层卵黄囊细胞膜脂质流动性及胎盘组织谷光甘肽（glutathione，GSH）含量的影响。

Objective To explore the effects of ursodeoxycholic acid ( UDCA ) on the fluidity of rat visceral sac and placental glutathione ( GSH ) concentration in rats with intrahepatic cholestasis .

妊娠期肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）是妊娠期特有的疾病，其特征为妊娠中、晚期孕妇出现瘙痒、黄疸及胆汁淤积，分娩后即迅速好转。

Intrahepatic cholestasis of pregnancy ( ICP ), characterized by pruritus , jaundice and biochemical evidence of cholestasis , occures in the second and third trimester of pregnancy and disappears quickly after delivery .

目的：研究妊娠期肝内胆汁淤积症（ICP）胎盘超微结构改变，探讨ICP时胎儿宫内生长不良及死亡原因。

Objective : To study the ultrastructural changes in placenta of Intrahepatic Cholestasis of Pregnancy ( ICP ) and to investigate the reasons of intrauterine growth retardation and intrauterine fetal death in ICP .

结果胎膜早破、胎盘因素、双胎、臀位、妊娠期肝内胆汁淤积症（ICP）、妊娠高血压疾病等为早产主要原因。

Results The main causes included premature rupture of membrane , placental factors , unknown aetiology , bigeminal , glutea position , intrahepatic cholestasis of gestational period ( ICP ), gestational hypertension and so on .

目的构建孕兔妊娠肝内胆汁淤积症（ICP）模型，为ICP围产儿并发症发生机制的研究提供适宜的动物模型。

Objective To establish a disease model for intrahepatic cholestasis in pregnant rabbits and provide a suitable animal model for the study on the mechanism of fetal complications of intrahepatic cholestasis of pregnancy ( ICP ) .

目的探讨选择素-P（P-selectin）在妊娠肝内胆汁淤积症（ICP）患者，脐带血管内皮细胞上的表达及干扰素（IFN-γ）、地塞米松（DEX）对其表达的影响；

Objective 1.To explore the expression of P-selectin in the endothelial cells of umbilical cord and the effects of IFN - γ and Dex amethasone ( DEX ) on its expression in ICP ;

目的观察妊娠肝内胆汁淤积症（IntrahepaticCholestasisofPregnancy，ICP）胎盘超微结构病理改变和表皮生长因子受体（EGFR）的表达，研究胆汁酸对滋养细胞的毒性作用及其对胎儿生长发育的影响。

Objective The cytotoxic effect of bile acids on trophoblast and fetal development in intrahepatic cholestasis of pregnancy ( ICP ) were studied through the observation of ultrastructure changes and expression of epidermal growth factor receptor ( EGFR ) of placenta .

孕激素受体基因多态性、MDR3基因错义突变与妊娠期肝内胆汁淤积症的相关性研究

Study on the Relationship between Progesterone Receptor Gene Polymorphism 、 MDR3 ( Multidrug Resistance 3 ) Missense Mutation and Intrahepatic Cholestasis of Pregnancy