肿瘤遗传学

病理学和肿瘤学从原始的大体病理，经过显微病理和特殊染色，发展至今又揉进了分子生物学和肿瘤遗传学的成分。

Pathology and oncology have progressed from a gross pathology beginning , through microscopy and special stains , and into the realm of molecular biology and tumor genetics .

2000年WHO脑肿瘤的分类反映了组织病理学、分子生物学和肿瘤遗传学的内容。

The 2000 WHO classification is based on histologic pathology , molecular biology and tumor genetics .

COX-2在大连地区胃癌中的低频率表达、甲基化状态及其肿瘤遗传学意义分析

Infrequent COX-2 Expression Due to Promoter Hypermethylation in Gastric Cancers of Dalian , China

Knudson于1971年提出的两次打击学说为肿瘤遗传学工作者提供了普遍接受的肿瘤发生机理学说，成为探讨肿瘤发生机制研究的理论基础。

Two hit hypothesis ( Knudson , 1971 ) is a scientific prophecy about the mechanism of tumorigenesis which is generally accepted by cancer geneticists , and has been the theoretical basis of tumorigenesis mechanism .

比较基因组杂交技术用于分析染色体DNA水平的改变，能获得良好结果并具有可重复性，从而提供了一条肿瘤细胞遗传学研究的可行路径。

CGH are applied to analyze DNA level changes of chromosome , can get good results and can be repeated well , it is an advisable way of tumor cellular genetic research .

因此，通过LOH定位寻找TSG是肿瘤分子遗传学研究的热点之一。

Therefore , it is one of hot spots in tumor molecular genetics to identify TSGs by mapping regions of LOH .

i（12p）阴性的睾丸生殖细胞肿瘤的遗传学特点及其临床意义

Cytogenetic features of I ( 12p ) - negative testicular germ cell tumors and its clinical significances

肿瘤分子遗传学新方法&比较基因组杂交

A New Molecular Cytogenetic Method in Tumor & Comparative Genomic Hybridization COMPARE

近年来，肿瘤分子遗传学研究表明，细胞的恶性转化与细胞内基因组的不稳定有关，基因组不稳定的研究成为探讨肿瘤发生机理的新热点。

In recent years , studies of tumor genetics have suggested the genetic instability of cell genome including LOH and MSI is associated with cell transformation , which produced a new hot-spot in the study of tumor carcinogenesis .

B淋巴细胞肿瘤分子细胞遗传学异常的研究

Study on Molecular Cytogenetic Abnormalities in B-lineage Lymphoid Malignancies

结论PNET是高度侵袭性肿瘤，随着遗传学和现代治疗学的进步，该肿瘤预后会逐步改善。

Conclusion PNET is a high malignant tumor . The prognosis has improved in the modern era of treatment and genetics . Invasion ;

消化道恶性肿瘤的细胞遗传学研究

Cytogenetic Study on Malignant Tumor of Alimentary Canal

胎盘部位过度反应及胎盘部位结节的临床病理分析滋养细胞肿瘤患者细胞遗传学研究

Clinicopathological study of intermediate trophoblastic non-tumor lesions : exaggerated placental site and placental site nodule

在这里的第二个研究，研究者报道，在黑人和白人乳腺癌女性肿瘤组织也存在遗传学的差异。

In a second study presented here , researchers reported on genetic differences that were identified in breast cancer tumors of black women and white women .

该克隆细胞系适用于肿瘤细胞生物学、肿瘤细胞遗传学、肿瘤分子生物学及抗癌药物筛选等深入研究。

It is suggested that CC-801 is suitable for studies on tumor biology , cancer cytogenetics , oncogene and screen of anticancer drugs .

从肿瘤的恶性转化和肿瘤发展的分子遗传学来看，胃癌是一种获得性的多阶段的基因病，它的生长、侵袭、凋亡与基因相关。

From malignant transformation and tumor development in terms of molecular genetics , cancer is a multi-stage acquired genetic disease , its growth , invasion and apoptosis are all associated with genes .

虽然大多数肿瘤是单克隆起源的，但由于肿瘤的遗传学不稳定性和靶器官的选择作用，肿瘤常常表现为一个不断变异的群体，有些瘤细胞亚群得以杂在靶器官优势生长，获得转移表型。

Although majority of the tumor come from monoclone , as a result of the tumor genetics instability and the target organ selective action , the performance of tumors variate unceasingly and some subclone obtains the metastatic phenotype .

DNA甲基化修饰导致的基因沉默在肿瘤发生、发展过程中普遍存在，与肿瘤遗传学改变不同，DNA甲基化是一种可逆的过程。

Gene silence induced by DNA methylation was prevalent in the process of tumor occurence and progression .