联合基因

IL-2和IL-12联合基因治疗小鼠肝癌的实验研究

Gene therapy with IL-2 and IL-12 for murine hepatocellular carcinoma

HBV与HCV的融合与联合基因免疫效果的研究

Study on the immunization effect of the chimeric and the united genetic immunization including HBV and HCV

Toll样受体亚型单一和联合基因沉默稳定易损斑块的实验研究

Stabilization of Vulnerable Plaques Using Isolated and Combinatorial Interference of Toll-like Receptor Subtypes : An Experimental Study

方法：采用HBV、HCV联合基因芯片检测40份血清标本，并与HBV，HCV基因定量检测方法比较；

METHODS : HBV and HCV in 40 serum samples were detected by mixed microarray and quantitative determination method as well ;

人IL-12和B7-1联合基因治疗黑色素瘤的实验研究

Experimental Study on hIL-12 and hB 7-1 Gene Therapy for Melanoma

DNA甲基化芯片联合基因表达谱芯片分析鼻咽癌紫杉醇耐药的方法能够有效、特异性地筛选耐药相关基因，是研究肿瘤耐药的一种非常好的手段。

Combined analysis of DNA methylation microarray and expression microarray was a good tool to study the mechanism of the cancer drug resistance development to identify effective and specific gene markers .

联合基因转移FasL、P21～（WAF1/CIP1）治疗人脑胶质瘤的实验研究

Experimental Study of Combination Gene Transfer FasL and P21 ~( WAF1 / CIP1 ) Therapy for Human Gliomas

目的研究GMCSF（粒单核巨噬细胞集落刺激因子）与抗原化抗体联合基因免疫时，GMCSF对TH细胞应答的调节作用。

Objective To investigate the effect of GM-CSF on the T helper cell response induced by gene immunization combined with GM-CSF and antigenized antibody .

IL-2和IL-12的单/联合基因治疗对肝癌大鼠体内IL基因表达和T细胞亚群的影响

Effect of IL-2 and / or IL-12 gene therapy on IL gene expression and T cell subpopulation in rats with liver cancer

人IL-12与结核分枝杆菌抗原ESAT-6联合基因疫苗的免疫效果观察

Immune effects research of interleukin 12 and Mycobacterium tuberculosis ESAT-6 antigen combined DNA immunization

HIV-1结构蛋白gag-gp120与白细胞介素2联合基因免疫

Co-inoculating DNA Vaccine of HIV-1 gag-gp120 and IL-2

HSV-TK、B7联合基因治疗诱发乳腺癌细胞凋亡及增强免疫作用的观察

Combined gene therapy of B7 and HSV-TK for tumor apoptosis and enhanced immunogenicity in the murine mammary cancer model

人白细胞介素12（IL-12）与结核分枝杆菌免疫优势抗原ESAT-6真核表达质粒联合基因免疫，诱导免疫应答效果观察。

To investigate the immune effects of combined DNA immunization of human interleukin 12 and Mycobacterium tuberculosis ESAT-6 antigen .

结果（1）α-内收蛋白基因、ACE基因各基因型及TrpTrp+DD联合基因型在正常血压组和EH组的分布差异无显著性。

Results ( 1 ) There were no statistical significance of polymorphism of alpha-adducin gene , ACE gene or TrpTrp + DD combined genotype between hypertensives and healthy subjects .

结论5-FC/yCD：：UPRT联合基因治疗策略对胶质瘤细胞C6有明显的杀伤作用。

Conclusions 5-FC / yCD : : UPRT combined gene therapy has a significant killing efficacy on malignant glioma C6 cells .

真菌源性CD：：UPRT联合基因治疗脑胶质瘤的实验研究

Efficacy of 5-FC / yeast CD : : UPRT combined gene therapy for malignant glioma

在对照组内，CTAA联合基因型的Hcy水平显著高于CCAA型（P0.01）。

In control group , the Hcy level in CTAA genotype was significantly higher than that in CCAA genotype ( P0.01 ) .

目的探讨5-氟胞嘧啶（5-FC）/CD∷UPRT联合基因系统对大鼠脑胶质瘤的治疗作用。

Objective To investigate the therapeutic effects of 5-FC / CD ∷ UPRT combinative gene on encephalic glioma xenograft in SD mice .

结论5-FC/CD∷UPRT联合基因对大鼠脑胶质瘤有显著的治疗效果。

( Conclusion ) 5-FC / CD ∷ UPRT combinative gene has a significant therapeutic effect on mice encephalic glioma .

结果：HBV，HCV联合基因芯片与HBVdna定量检测的符合率为85%（34/40），HBV检出率为83%（19/23），假阳性率为12%（2/17）；

RESULTS : The coincident rate of mixed microarray and quantitative determination of HBV DNA was 85 % ( 34 / 40 ) . The detectable rate of HBV by mixed microarray was 83 % ( 19 / 23 ); 2 of 17 samples showed false positive reaction .

两位点联合基因型的分析显示，对照组B2B2CC基因型携带者血清高密度脂蛋白较B1B1CC型者显著升高（P0.05），B2B2CC型者与B1B1CC型者比较，甘油三酯水平显著降低（P0.05）。

No significant changes of lipid and lipoprotein levels were observed in both polymorphism in HTG group . Combined genotype analysis of the two sites , subjects with genotype B_2B_2CC in normal controls had higher HDL-C levels but lower serum triglyceride ( TG ) when compared with B_1B_1CC .

经过单因素分析及分层分析，年龄、性别、打蔚、肥胖、高血压家族史、脉压差、心率、血生化指标中ALT、UA、TG、TC、VLDL以及DD+AC联合基因型与EH有关。

Essential hypertension was statistically associated with age , sex , BMI , snoring , family hypertension history , heart rate , ALT , UA , TG , TC , VLDL and DD + AC gene type after single factor and stratified analysis .

结论脾内直接注射IL2和或IL12基因可增强T细胞活性，IL联合基因治疗优于IL单基因。

Conclusion IL 2 and / or IL 12 genes injected directly into spleen increase the T cell activity . Combined treatment with IL 2 / IL 12 genes is superior to that of IL gene alone .

目的：研究携带小鼠白细胞介素12（mIL-12）和人白细胞介素2（hIL-2）基因的逆转录病毒包装细胞株对大鼠肝癌进行联合基因治疗的可行性和疗效。

Objective : To evaluate the feasibility and efficacy of combination gene therapy for hepatocellular carcinoma using retroviral packaging cell line encoding interleukin 12 and interleukin 2 genes in rat models .

基于超顺磁性四氧化三铁磁性纳米颗粒的恶性胶质瘤靶向联合基因治疗

Targeted Multi-Gene Therapy of Malignant Glioma Based on Superparamagnetic Fe_3O_4 Magnetic Nano-particles

白介素18和胞嘧啶脱氨酶基因对小鼠肝癌的联合基因治疗

Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes

这为今后恶性胶质瘤放射治疗联合基因治疗提供新的思路。

It provides new ideas for future radiotherapy combined with gene therapy of glioblastoma .

恶性颅内肿瘤的联合基因治疗及结果评价

Combined gene therapy for malignant brain tumor

重组融合蛋白及联合基因转染阻断肿瘤侵袭与转移的研究

Studies on the Inhibition of Tumor Invasion and Metastasis by Recombinant Fusion Protein and Combined Gene Transfection

联合基因较单基因抑制效果好，有协同作用。

The united genes may have better inhibitor effect than single gene , because there are synergism between them .