端粒效应
端粒效应-
端粒位置效应与人类衰老
Telomere Position Effect and Human Senescence
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在人类细胞中也存在端粒位置效应，并且有多种因子参与此效应，它可能对细胞生长停止、肿瘤以及衰老发生时等许多随端粒缩短密切相关基因的程序性表达产生重要作用。
Recently , it has been demonstrated in human cells and found that many factors are involved . TPE may play an important role in programmed gene expression by telomere shortening with implications for cellular senescence and cancer .
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另外，端粒中存在一种特殊的现象：端粒位置效应，它首先在酵母中发现，表现为靠近端粒序列附近的基因表达因端粒的位置效应而沉默。
In addition , telomeres have special phenomena : the expression of genes near telomeres are silenced by telomere position effect ( TPE ) originally found in yeast .