突变型基因

采用这个改良的方法，分析了拟南芥野生型和ast突变型基因表达的差异。

Based on the improved procedure , the differential gene expression were studied between immature siliques of Arabidopsis wide type and ast mutant .

SHP-2野生型基因可促进乳腺癌转移而其突变型基因可抑制转移

The wild-type SHP-2 gene promotes but the mutated SHP-2 gene inhibits the metastasis of breast cancer

突变型p53基因产物的表达也与胃癌肝转移密切相关（P＜0.01）；

Expression of mutant p53 gene product was also related to metastasis of stomach cancer to liver ;

采用一步法RT-PCR检测突变型p53基因mRNA水平的表达。

The mRNA expression of mutant p53 gene was detected by one-step RT-PCR .

下调突变型P53基因蛋白的表达；

Regulating the expression of mutation P53 gene down ;

突变型p53基因在人膀胱肿瘤中的表达及临床意义

Abnormal expression and clinical significance of muta-tion p53 gene on human bladder cancer

HP感染可促进突变型p53基因表达增强。

It was supposed that HP infection caused mutated p53 gene expression to increase .

目的：探讨突变型p53基因产物在胃癌中异常表达的意义。

Objective : To investigate the significance of abnormal expression of p53 in gastric carcinoma .

胃癌细胞DNA倍体和突变型p53基因产物表达与转移扩散的关系

A Study on DNA Ploidy , Mutant p53 Gene Product Expression and the Relationship with Metastasis in Stomach Cancer

胃癌中VEGF及突变型p53基因表达及临床意义研究

Expressions of VEGF and mutant p53 gene and their clinical significance in patients with gastric carcinoma

研究表明突变型p53基因（mt-p53）可上调血管内皮生长因子（VEGF）的表达，促进血管生成。

The wide type p53 gene promotes vessel formations by up-regulating vascular endothelial growth factor ( VEGF ) .

鼠双微粒体-2基因和突变型p53基因表达与肝癌细胞增殖和凋亡关系的研究

Expression of Murine Double Minute-2 Gene and Mutant p53 and Their Relation with Cell Proliferation and Apoptosis in Hepatocellular Carcinoma

突变型P53基因在正常胃黏膜，浅表性胃炎和萎缩性胃炎中不表达，在重度异型增生与胃癌组织间无显著差异（p>0.05）。

No significant difference was observed for p53 expression level between severe dysplasia and carcinoma ( p > 0.05 ) .

方法通过向肺癌细胞中分别转染携带有荧光蛋白基因的野生型P53基因和突变型P53基因，而后用荧光显微镜观察荧光蛋白表达；

Methods Through transfection to lung cancer cells p53 gene with fluorescent protein gene , and observation of expressed products by fluorescent microscopy .

提示Bcl－2及突变型p53基因产物与甲状腺肿瘤的发生、发展及预后有关。

The results indicate that the expression of Bcl-2 and mutant-type p53 in thyroid tumor is associated with tumor genesis , growth and prognosis .

目的探讨突变型P53基因在人乳腺癌组织中的表达规律及其与淋巴结转移等之间的关系。

To research expression of the mutated p53 gene in human breast cancers and its correlation with lymph node metastasis and other prognostic factors .

结论：灵芪胶囊对H（22）荷瘤小鼠有明显抑瘤作用，其机制可能与抑制突变型p53基因和bcl-2基因表达有关。

Conclusion : Lingqi-capsule can obviously inhibit mice sarcoma H_ ( 22 ) . The mechanism of action is correlation of p53 and bcl-2 gene expression decrease .

突变型Axin基因在神经胶质瘤细胞系C6中的功能研究

Functions of mutant Axin gene in C6 glioma cell line

初步证据显示，在转基因青蒿植株中，突变型SS基因已取代野生型SS基因。

The preliminary data showed that the wild-type SS gene was replaced by mutated SS gene in the transgenic A. annua plant .

突变型p53基因的编码蛋白不但丧失上述功能，甚至出现了促使细胞癌变的作用。

The protein ( P53 ) encoded by mutant p53 gene ( mtp53 ) not only losses these functions , but also make cell malignant transformation .

目的：探讨大肠腺癌突变型p53基因蛋白表达与p53基因cDNA突变间的相互关系和意义。

Purpose To analyse the significance and relationship between the expression of mutant type p53 gene protein and p53 gene cDNA mutation in the colorectal adenocarcinomas .

上述结果提示：胃癌细胞的DNA非整体倍体和突变型p53基因产物的表达在其血行转移过程中起重要作用，但作用机理可能有所不同。

The results suggest that both DNA aneuploid and the expression of mutant p53 gene product play important role in blood metastasis , the machanism may not be the same .

目的分析燃煤型砷中毒患者皮肤癌变过程中增殖细胞核抗原（PCNA）、B-淋巴细胞瘤/白血病-2抗凋亡蛋白（BCL-2）和突变型P53基因蛋白（P53mt）的表达情况及相关性。

Objective To analyze cooperative expressions of PCNA , BCL 2 and P53 mt proteins in patients ' skin with arseniasis due to coal burning .

结论PD可有效降低肺动脉压，延缓大鼠CHPH进程，其机理可能与抑制突变型p53基因表达及细胞增殖，从而有效抑制肺血管重建有关。

It may be related to the inhibition of p53 which can enhance proliferation and decrease apoptosis , that contribute to postpone the development of pulmonary vascular remodeling .

转染突变型NPM基因，观察其对白血病细胞增殖和凋亡的影响。

To observe the effect of mutated NPM on proliferation and apoptosis of KG-1a cells .

以上结果表明：突变型p53基因在CNE－2Z细胞中有较高表达；通过抑制细胞PKC活性和耗竭PKC含量后，均可降低p53基因的表达；

These results indicated that mutate p53 gene in CNE 2Z cells showed a high expression and it reduced markedly by inhibiting the PKC activity or reducing the PKC content .

首先在通过脂质体介导下将突变型NPM基因转染入KG-1a细胞并筛选稳定表达株。

Firstly , NPM mutant gene was transfected into KG-1a using Lipofectamine 2000 .

突变型flk-1基因转染抑制肝癌在裸鼠体内血管形成、生长和转移

Gene Transfer of Dominant-Negative flk-1 Mutant Inhibits Angiogenesis , Growth and Metastases of Human Hepatocellular Carcinoma in Nude Mice

主要的结果和结论如下：1.检测KG-1a细胞中CD34抗原和突变型NPM基因的表达。

Main results and conclusions as follow : 1 . CD34 molecule and expression of NPM mutant gene in KG-1a cells was detected .

结果转染突变型Axin基因与转染野生型Axin基因的C6细胞在生长速度，克隆形成能力方面均显著降低，且组间无差别；

Results In comparison with the cells transfected with empty vector , the growing speed and colony formation ability of the cells transfected with wild Axin gene and mutant Axin gene were decreased significantly ;