碳青霉烯

碳青霉烯类药物的使用可以诱导外膜孔道蛋白基因缺失，从而增加对碳青霉烯类抗菌药物的MIC值。

Using carbapenem antibiotic can induce the deletion of out membrance porin gene , thus increasing MIC values of carbapenem antibiotic .

碳青霉烯类药物抗生素后效应研究概况

A survey of studies on post antibiotic effect of carbapenem antibiotic

目的研究碳青霉烯类化合物的定量构效关系（QSAR），并进行新的碳青霉烯类化合物的分子设计。

Objective To study the quantitative structure-activity relationship ( QSAR ) of carbapenems and the design of new compounds .

采用病例-对照研究方法，运用t检验、x~2检验、非条件Logistic回归分析PA对碳青霉烯耐药的危险因素。

Case-control study was conducted to identify risk factors for carbapenem-resistance and data were analyzed by Chi-square test and unconditional Logistic regression .

所发现的超级细菌是耐碳青霉烯类肠杆菌，简称CRE。

The superbug found was carbapenem-resistant Enterobacteriaceae , or CRE .

目的调查不动杆菌属对碳青霉烯类的耐药性，研究碳青霉烯类耐药的不动杆菌（CRAB）分子流行病学及耐药机制。

Objective To investigate antimicrobial resistance in Acinetobacter species and molecular epidemiology and resistance mechanism of carbapenem-resistant Acinetobacter species ( CRAB ) .

结论所建立的定量构效关系模型能有效的进行碳青霉烯类化合物的MIC值的预测和化合物筛选，为碳青霉烯类抗生素新药开发提供新的参考和思路。

Conclusion Results showed that the proposed QSAR model could be applied for the prediction of MIC and the screening of new compounds .

结论大肠埃希菌对β内酰胺类抗生素耐药的主要原因是产生AmpC酶和ESBLs，对产酶菌株临床经验用药可选用碳青霉烯类抗生素。

Conclusions Producting AmpC and ESBLs is the main mechanism of resistance in E. coli . Carbopenems could be chosen as clinical experiential medication .

所有对亚胺培南耐药鲍曼不动杆菌明确产OXA-23型碳青霉烯酶，未检出OXA-24、IMP、VIM基因型。

All the 34 imipenem resistance isolates produced OXA-23 and no OXA-24 , IMP , VIM were detected .

通过比较得到更优的给药方案，并将优化给药方案应用于临床病例中，观察临床疗效。结果：1.对于肠杆菌科细菌，碳青霉烯类抗生素能获得理想的CFR。

Then we applied optimum regimen to clinic and observed clinical therapeutic effect . Results : 1.Against Enterobacteriaceae , carbapenems attained optima CFR .

产KPC型酶是肺炎克雷伯菌对碳青霉烯类抗菌药物耐药的主要耐药机制之一。

Producing KPC enzyme is one of the most resistant mechanism to carbapenems for Klebsiella pneumoniae .

碳青霉烯类抗生素Doripenem的合成及工艺研究

Synthesis and Study on the Synthetic Technique of Doripenem

结果：2003年1月～2005年12月我院共分离到30株碳青霉烯类中介或耐药的鲍曼不动杆菌，其中儿科ICU病房9株，外科ICU病房12株。

Results Thirty Acinetobacter baumannii strains were carbapenem-intermediate and - resistant from January 2003 to December 2005 . Nine strains were isolated from pediatric ICU ( PICU ), and 12 strains were from surgical ICU ( SICU ) .

结果：下呼吸道分离大肠埃希菌和肺炎克雷伯菌ESBLs阳性率分别为78.72%、57.50%：产ESBLs菌对多数抗菌素的耐药率显著高于非产酶菌，所有菌株对碳青霉烯类都敏感；

Coli was 78.72 % , K. pneumoniae was 57.50 % . The drug resistance of positive ESBLs was higher than that of negative ESBLs to most drugs , and most of them were multiple-drug-resistances .

产ESBLs大肠杆菌是医院感染的重要病原菌之一，治疗一般均首选碳青霉烯类抗生素，选择性压力较大，且易诱发真菌等二重感染。

Coli producing ESBLs is one of the most important pathogens of nosocomial infection . Carbopenems antibiotics are the first choice of therapy , but the selective pressure is high , and easy to induce secondary infection of fungi and so on .

研究不动杆菌对碳青霉烯类耐药的分子机制，确定β内酰胺酶、整合子、外膜蛋白（OMP）及外排泵在多重耐药和泛耐药不动杆菌属中所起的作用。

To study the molecular mechanism of resistance to carbapenems ; To determine the role of β - lactamases , integrons , outer membrane proteins ( OMP ) and efflux pumps in mediating the resistance to multiple drugs or pan-drugs among Acinetobacter species .

答：NDM1是一种酶，对最有效的抗生素类别之一，即碳青霉烯类抗生素，产生耐药性。但是，观察到的情况在许多方面不同于我们迄今见过的情况。

A : NDM1 is an enzyme that confers resistance to one of the most potent classes of antibiotics , known as carbapenems , but what has been observed is different in many ways to what we have seen to date .

12株碳青霉烯类耐药菌株均携带pIs5.8、6.9和7.2三种β-内酰胺酶和OXA23基因，11株上海菌株中检测出PER1型基因和3株菌株检测到TEM-相似基因。

All 12 strains produced three β - lactamases with pIs 5.8 、 6.9 and 7.2 and an OXA-23 gene . PER-1 type gene were detected in 11 isolates and TEM-like gene in three isolates . OXA-24 gene was not detected in any of these isolates .

1β-甲基碳青霉烯类抗生素美罗培南合成进展

Progress in synthesis of 1 β - methyl carbapenem antibiotic meropenem

39例碳青霉烯耐药的肺炎克雷伯杆菌感染的临床分析

Clinical Analysis of 39 Patients with Carbapenem Resistant Klebsiella Pneumoniae Infection

肠杆菌科细菌碳青霉烯类抗菌药物耐药机制研究

A Study on the Molecular and Epidemical Mechanism of Carbapenem-Resistance Enterobacteriaceae

耐碳青霉烯类鲍曼不动杆菌金属β-内酰胺酶的研究

Study of metallo - β - lactamase of Carbapenems-resistant Acinetobacter baumanii

碳青霉烯抗生素对质粒介导β-内酰胺酶的稳定性及抑酶效应研究

Study of stability and inhibitory activity of carbapenems against β - lactamases

目的：促进临床对碳青霉烯类抗生素的合理应用。

OBJECTIVE : To promote clinical rational use of carbopenems .

鲍曼不动杆菌对碳青霉烯类抗生素耐药基因研究

Study on gene for resistance of carbapenems in Acinetobacter baumannii

碳青霉烯类药物对铜绿假单胞菌体外抗菌行为比较

Comparing in vitro antibacterial behaviors of carbapenems against Pseudomonas aeruginosa

头孢菌素类的应用是产生碳青霉烯类耐药的重要危险因素之一。

Application of cephalosporins is an important risk factor of carbapenem resistance .

目的碳青霉烯类抗生素是治疗多重耐药肠杆菌科细菌感染的一线药物，由于此类抗生素应用的增多，对碳青霉烯耐药的临床株陆续出现。

Objective : Carbapenem is the first-line drug to treat multidrug-resistant Enterobacteriaceae .

循证药学在碳青霉烯类药物临床使用中的应用

Application of Evidence-Based Pharmacy in Clinical Practice of Carbapenem

一例碳青霉烯类抗菌药物耐药的肺炎克雷伯菌耐药机制研究铜绿假单胞菌在多药耐药肺结核患者中的耐药分析

Antibiotic Resistance Analysis for Pseudomonas aeruginosa among Patients with Multi-drug Resistance Pulmonary Tuberculosis