硫辛酸

用石英晶体微天平（QCM）在线监测了硫辛酸（TA）在金电极上自组装成膜动力学过程。

The formation of thioctic acid ( TA ) self-assembled monolayer ( SAM ) on gold electrode was monitored in situ by using quartz crystal microbalance ( QCM ) .

硫辛酸在金电极上自组装成膜动力学研究

Kinetic studies on formation of self-assembled monolayer of thioctic acid on gold electrode

α-硫辛酸对糖尿病神经病变大鼠坐骨神经蛋白激酶C活性的影响

Effects of ALA on PKC Activity on Sciatic Nerve in Diabetic Peripheral Neuropathy Rats

高糖诱导人脐静脉内皮细胞表达NF-кB而α-硫辛酸有抑制作用

High Glucose Induce NF - к B Expression on Human Umbilical Vein Endothelial Cells and Alpha-lipoic Acid Can Inhibit It

HPLC测定硫辛酸注射液的含量与有关物质

Determination of Thioctic Acid Content and Relative Substances in Thioctic Acid Injection by RP-HPLC

《国际糖尿病》：您在您的演示文稿中强调，维生素C也是一个非常有效的抗氧化剂，与α-硫辛酸类似。

International Diabetes : You highlighted in your presentation that vitamin C is also a very effective antioxidant comparable to alpha-lipoic acid .

α-硫辛酸（lipoicacid，LA）广泛存在于各种细胞中。

Lipoic acid ( LA ) exists widely in all kinds of cells .

硫辛酸对急性肺损伤大鼠IL-10的影响

The effects of lipoicacid on interleukin-10 in acute lung injury rat

结论：H2O2对细胞DNA损伤具有剂量效应关系，硫辛酸可以有效地减少22H2O2引起的细胞DNA的断裂损伤。

CONCLUSION : H_2O_2 causes DNA damage of cells in a dose-effect manner , while lipoic acid can reduce effectively this DNA damage caused by H_2O_2 .

硫辛酸对老年大鼠肾缺血再灌注后肺损伤时黏附分子ICAM-1表达的影响

Effect of lipoic acid on expression of ICAM-1 of lung tissue following renal ischemia reperfusion in aged rats

其中Baeyer-villiger是生成R型的α-硫辛酸的关键步骤。

The key step to the synthesis of α - thioctic acid is the Baeyer-villiger oxidation .

口服硫辛酸对AMD患者血脂及抗氧化能力影响

Effect of oral lipoic acid administration on blood lipids and antioxidative ability in patients with age-related macular degeneration

结论：一定浓度的α-硫辛酸可抑制高糖诱导的系膜细胞增殖，并可降低ICAM-1蛋白和mRNA的表达。

Conclusion : Certain concentrations of α lipoic acid can inhibit high glucose-induced proliferation of MCs and decrease the expression of ICAM-1 protein and mRNA .

依贝沙坦和硫辛酸改善代谢综合征患者内皮功能并减少炎症标志物：依贝沙坦和硫辛酸对内皮功能影响的研究（ISLAND）结果

Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome : Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction ( ISLAND ) study

目的探讨α硫辛酸（LA）和牛磺酸（Tau）对急性镉氧化损伤的影响。

Objective To study the effects of alpha-lipoic acid ( LA ) and taurine ( Tau ) on acute oxidative damage caused by cadmium .

32只SD大鼠分成4组，分别是正常饲料对照组、高脂饲料组、高脂饲料+硫辛酸（0.1%）组和高脂饲料+N-乙酰半胱氨酸（0.1%）组。

32 SD rats were divided into 4 groups : control group , high-fat group , LA group ( 0.1 % ) and NAC group ( 0.1 % ) .

α-硫辛酸在哺乳动物细胞内可以部分转化为还原型的二氢硫辛酸（dihydrolipoicacid，DHLA）。

It can be converted into dihydrolipoic acid ( DHLA ) in mammal cells .

目的研究谷胱甘肽（GSH）和α-硫辛酸（LA）对锰致大鼠脑组织氧化损伤及纹状体神经元凋亡的影响。

Objective To study the effects of glutathione ( GSH ) and alpha-lipoic acid ( LA ) on rats brain oxidative damage and striatum neuron apoptosis induced by manganese .

枸杞多糖大剂量组与α-硫辛酸对照组均能降低血清和坐骨神经组织中MDA至正常水平（P0.05）。

( P0.05 ) The high doses of LBP group and α - Lipoic acid group both could attenuate the content of MDA in serum and sciatic nerve to the normal level ( P0.05 ) .

目的本研究观察高浓度葡萄糖对体外培养的大鼠晶状体的损害，以及抗氧化剂DLα硫辛酸（LA）的保护作用。

Objective To probe into the effects of glucose on the culture rats ' lenses and the response to the antioxidant DL - α - Lipoic acid ( LA ) .

RoyFreeman教授：有一个主要的强有力的证据支持在治疗神经病变性疼痛时应用静脉α-硫辛酸。

Prof Roy Freeman : There is a strong body of evidence in supporting the use of intravenous alpha-lipoic acid in the treatment of neuropathic pain .

结果表明：硫辛酸在XAD4树脂上是单层吸附，符合Langmuir等温吸附方程，吸附过程符合准一级动力学吸附方程。

The results showed that the adsorption of lipoic acid on XAD 4 resin is Langmuir monolayer , and the adsorption rate appears to be the first order kinetics .

α-硫辛酸、牛磺酸对镉致大鼠氧化损伤和Bax、JNK基因RNAi对镉致293细胞凋亡影响的实验研究

Experimental Study on the Effects of LA , Tau on Oxidative Injuries in Rats and the Effects of RNAi on Bax , JNK on Apoptosis in 293 Cell Induced by Cadmium

用GC-FID和GC-TOF-MS方法分析α-硫辛酸中有机溶剂残留量

Determination of residual solvents in α - lipoic acid by GC-FID and GC-TOF-MS

α-硫辛酸是一种抗氧化剂，已有研究表明其可以减少或淬灭机体产生的自由基，抑制低密度脂蛋白（LDL）的氧化，对内皮细胞具有直接的保护作用。

α - lipoic acid is an antioxidant , studies have shown that it can reduce or direct quenches the production of free radicals , restrain the oxidation of low-density lipoprotein ( LDL ) so as to protect endothelial cells .

目的：研究通络方剂和褪黑素、α-硫辛酸和金属硫蛋白等抗氧化剂对糖尿病大鼠心肌细胞和组织的抗凋亡作用及超氧化物歧化酶2（SOD2）、泛素D表达的影响及其作用机理。

Objective : to investigate the effect of Tongluo recipe and melatonin , Metallothionein , a-lipoic acid on diabetic cardiomyopathy in rats .

方法：将细胞分为对照组、损伤组和保护组，依次加入不同浓度的H2O2及硫辛酸，应用SCGE检测H2O2引起细胞DNA损伤。

METHODS : HepG_2 cells were divided into control group , damage group and protective group , then were added with different concentrations of H_2O_2 and lipoic acid . Two hours later , the single cell gel electrophoresis ( SCGE ) was used to detect the DNA damage .

方法：25只小鼠随机分成正常对照组，糖尿病组，α-硫辛酸治疗低剂量组、中剂量组、高剂量组（分别15mg/kg、30mg/kg、60mg/kg腹腔注射共14d）。

Methods : Alloxan-induced KM diabetic mice were randomly divided into four groups , untreated diabetes group and three treatment groups with different doses of alpha-lipoic acid ( 15 mg / kg ip , 30 mg / kg ip and 60 mg / kg ip ) .

怀特和他的同事，在麻省理工学院化学系副教授爱丽丝汀的带领下，首先研制出一种荧光素连接酶，它来源于天然大肠杆菌硫辛酸连接酶（LplA）。

White and colleagues , headed by MIT associate professor of chemistry Alice Ting , first engineered a fluorophore ligase derived from the natural Escherichia coli enzyme lipoic acid ligase ( LplA ) .

硫辛酸修饰胰岛素与胰岛素受体的结合能力

The binding potency of lipoic acid modified insulin with insulin receptor