无精子症

血清抑制素B在非梗阻性无精子症中的应用

Application of serum inhibin B in non-obstructive azoospermia

无精子症患者睾丸组织病理分型与血清抑制素B关系的研究

Relationship Between Pathological Alterations of Spermatogenic Impairment and Serum Inhibin B Concentration in Patients with Azoospermia

严重少精子、无精子症患者外周血雄激素受体mRNA的表达研究

Investigation of androgen receptor mRNA expression in severe oligozoospermia of azoospermia patients

无精子症精浆果糖定性与精浆pH分析

Qualitative Analysis of Fructose and Quantitative Analysis of pH in Seminal Plasma of Azoospermia Patient

目的探讨抑制素B对非梗阻性无精子症病人睾丸精子获取成功的预测价值。

Objective To investigate the usefulness of serum inhibin B for successful testicular sperm extraction ( TESE ) in patients with non-obstructive azoospermia .

方法采用多重PCR技术，对63例原发性无精子症患者和20例正常已生育男性对照进行Y染色体微缺失的检测。

Methods : Multiplex PCR was used to detect Y chromosome microdeletion in 63 azoospermia patients and 20 healthy controls .

IGF-1在非梗阻性无精子症睾丸组织中的表达

Expression of IGF-1 in non-obstructive azoospermia testicle tissue

结论非手术抽吸睾丸精子联合ICSI是治疗梗阻性无精子症的一种有效方法。

Conclusion Non-surgically sperm aspiration is effective for azoospermic patients by ICSI .

方法：对143例无精子症患者进行UU培养和精浆生化分析。

Methods : UU culture and seminal plasma biochemistry analysis on 143 Azoospermia patients are performed .

方法采用PCR技术对16例高FSH无精子症患者Y染色体长臂上11个序列标记位点进行微缺失的检测。

Methods Eleven sequence tagged sites ( STSs ) in Yq were detected by PCR in 16 male patients ' high FSH azoospermia .

目的：探讨单精子卵胞浆内穿刺术（ICSI）治疗严重精液异常和梗阻性无精子症所致不育的疗效。

Purpose : To investigate the efficacy of ICSI treatment for severe male factor infertility .

此外无精子症组血清和精浆PRL比值差异较明显。

On the other hand the PRL ratios in blood and semen had a significant difference in azoospermia .

结论采用附睾/睾丸精子行ICSI是治疗男性阻塞性无精子症的有效方法。

Conclusions ICSI with PESA or TESE is an effective method for treatment of obstructive azoospermic patients .

目的探讨高促卵泡成熟激素（follicle-stimulatinghormone，FSH）无精子症与Y染色体基因微缺失的关系。

Objective To explore the relationship between the patients ' high follicle-stimulating hormone ( FSH ) azoospermia and microdeletions in Y chromosome .

方法运用PCR及琼脂糖凝胶电泳等方法，对成都地区42例原发性无精子症患者进行了AZF基因微缺失筛查。

Methods AZF microdeletion screening was carried out in 42 idiopathic azoospermia patients in Chengdu area by using PCR and gelose gel electrophoresis .

先天性梗阻性无精子症患者CFTR基因突变及其睾丸超微结构的研究和ICSI治疗的临床观察

Study of CFTR Gene Mutations and Testicular Ultrastructure and ICSI of Congenital Obstructive Azoospermia

CFTR突变基因不影响先天性梗阻性无精子症患者ICSI治疗的成功率

CFTR mutations have no effect on results of ICSI in congenital obstructive azoospermia patients

方法应用PCR技术对50例无精子症和严重少精子症患者（其中无精子症38例，严重少精子症12例）的外周血细胞进行DAZ基因检测。

Methods DAZ gene of peripheral blood leukocytes was detected by PCR technique in 38 azoospermia and 12 severe oligozoospermia patients .

除阻塞性无精子症组外，其余各不育组与正常生育组相比，精浆中MDA水平均有显著性差异（P<001）。

Exception of obstructive azoospermic group , MDA concentrations of seminal plasma in control group made very significant difference from those in other infertile groups ( P < 0.01 ) .

目的研究染色体异常及Y染色体AZF微缺失与无精子症的关系。

Objective : To investigate the relationship between chromosomal abnormality , AZF microdeletion and azoospermia .

方法：45例无精子症病人采用放射免疫法（RIA）检测性激素，瑞吉染色法进行精液细胞学检查。

Methods : Radioimmunoassay ( RIA ) and Wright Giemsa stain were used to detect serum sexual hormone and sperm cytology in 45 aspermia patients .

共获得128个可能与无精子症相关的差异表达基因，其中56个基因表达上调，72个基因表达下调，cDNA微矩阵杂交结果经原位杂交证实。

Totally 128 differential expressed genes might be related to azoospermia were found by the cDNA microarray hybridization , among them 56 were up regulated genes and 72 were down regulated .

环磷酰胺诱导少精子/无精子症大鼠模型所致睾丸、附睾IGF-I的变化

The Changes of IGF - ⅰ in Testis and Epididymis on a Rat Model with Oligoazoospermia / azoospermia Induced by Cyclophosphamide

目的：观察睾丸细针穿刺吸液（FNA）细胞学检查的效果，为诊断阻塞性无精子症提供新的诊断方法。

Objective : Using testicular cytology by fine needle aspiration ( FNA ) to diagnose obstructive azoospermia .

方法将男性不育症病人分为原发性无精子症、严重少精子症和梗阻性无精子症3组，另设正常对照组，分别测定其抑制素B、FSH及精子密度。

Methods Male infertile patients were divided into 4 groups , that is primary azoospermic , serious oligozoospermic , obstructive azoospermic and normal . Serum inhibin B , FSH and spermic density were tested respectively .

在促性腺激素未被完全抑制组中，CAG重复数大于22的受试者达到无精子症的机会是其他受试者的1.5倍。

In cases with incomplete gonadotrophin suppression , the chances of becoming azoospermia were 1.5 times higher in men with CAG repeats number more than 22 .

结果：4例无精子症和2例严重少精子症患者有RBM基因微缺失。

Results : RBM gene microdeletion was observed in 4 azoospermia and 2 severe oligozoospermia patients .

目的：探讨血清抑制素B（INHB）对非阻塞性无精子症（NOA）患者睾丸精子存在与否的预测价值。

Objective : To evaluate the predictive value of serum inhibin B ( INH B ) levels as an indicator of the presence of testicular spermatozoa in nonobstructive azoospermia .

本文综述Y染色体无精子症因子（AZF）区及其与精子生成相关候选基因的研究进展。

A spermatogenesis locus has been mapped on the Y chromosome , named azoospermia factor ( AZF ) .

方法：应用经皮附睾精子抽吸术（PESA）和睾丸精子获取术（TESE）两种方法对385例无精子症患者进行穿刺检查。

Methods : We examined 385 azoospermia patients using the techniques of PESA and TESE .