甲基强的松龙

大剂量维生素C与小剂量甲基强的松龙联合治疗大鼠急性脊髓损伤初步研究

The effects of therapy with high-dose Vitamin C combined with low-dose methylprednisolone for acute spinal cord injury in rat

目的探讨损伤前应用甲基强的松龙（MP）对脊髓损伤的影响。

Objective To investigate the effect of methylprednisolone administrated before spinal cord injury .

反相HPLC法测定血浆中的氢化可的松和甲基强的松龙

Determination of Hydrocortisone and Methylprednisolone in Plasma by Reversed & P has e HPLC

B组：15只，连续3d腹腔内注射甲基强的松龙45mg/kg。

Group B ( 15 ) was received an intraperitoneal injection of 45 mg / kg of methylprednisolone acetate for three consecutive days .

提示：经胸电击可升高PT，降低IDA；甲基强的松龙可减轻这种作用。

Methylprednisolone can reduce the effect of shock on PT and IDA .

目的研究注射用甲基强的松龙的应用剂量对重症SARS患者的疗效和不良反应的影响。

Aim To study the effect and ADRs of metrisone dosage to critical patients of SARS .

MMP-9、TIMP-1在实验性自身免疫性肌炎中的表达及甲基强的松龙的影响

The expression of MMP-9 and TIMP-1 in EAM and the effects of methylprednisolone

目的研究大剂量Vitaminc对大鼠急性脊髓损伤（SCI）疗效并与甲基强的松龙（MP）相比较。

Objective To investigate the therapeutic effect of high-dose Vitamin C on acute spinal cord injury ( SCI ) in rats .

目的观察心肌缺血再灌注时心肌细胞核因子-κB（NF-κB）活性的变化以及甲基强的松龙对心肌缺血再灌注损伤的影响。

Objective To study the changes of nuclear factor-kappa B ( NF - κ B ) and cytokines in myocardial Ischemic / Reperfusion injury during cardiopulmonary bypass ( CPB ) .

目的采用大剂量甲基强的松龙冲击治疗小儿急性肺损伤（ALI），评价其疗效。

Objective There are different opinions on large dose methylprednisolone impact therapy for acute lung injury .

目的观察甲基强的松龙对大鼠颅脑损伤后血、脑组织中NOS含量的影响，并探讨其作用机制。

Objective To observe the role of methylprednisolone by change of NOS level in rat brain trauma tissue .

甲基强的松龙对狼疮性肾炎患者血浆中PAI-1的影响

Methylprednisolone 's influence on the plasma plasminogen activator inhibitor-1 in lupus nephritis patients

甲基强的松龙对香烟烟雾提取物诱导A549细胞I-κBα的影响

The Alteration of I - κ B α induced by cigarette smoke extract and effect of Methylprednisolone in the human pulmonary cell type ⅱ

目的探讨依次采用少量血浆交换、大剂量丙种球蛋白、大剂量甲基强的松龙治疗重症肌无力（MG）Ⅱb或Ⅲ型的临床疗效及安全性。

Objective To explore the clinic effect and reliability Treated with a little plasma exchange ? large dosage beriglobin and large dosage methylprednisolone in myasthenia gravis ( MG )ⅱ b or III.

治疗组40例给予甲基强的松龙1~2mg/（kg·次），轻度哮喘1次静滴，中、重度2次/d静滴；

Forty cases received methylprednisolone 1 ~ 2 mg / kg , once a day for the light cases , twice a day for the secondary or the heavy ones .

甲基强的松龙对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响

Influence of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats

甲基强的松龙对脑损伤大鼠血清神经组织蛋白S100和神经元特异性烯醇化酶的影响

Effects of methylprednisolone on serum S-100B protein and neuron specific enolase in rats with brain injuries

研究目的：观察小剂量抑肽酶及甲基强的松龙对体外循环（CPB）炎性反应的影响。

Objective : To observe the effects of low-dose aprotinin and methylprednisolone on the inflammatory response induced by cardiopulmonary bypass ( CPB ) .

目的：研究大剂量甲基强的松龙（MP）治疗急性脊髓损伤的临床效果。

Objective : To investigate the clinic effects of high dose of methylprednisolone ( MP ) on acute spinal cord injury ( ASCI ) .

但三种浓度的甲基强的松龙（0.05μM、0.10μM、0.15μM）对AM分泌IL-6均无显著抑制作用。

But all three concentrations of methylprednisolone ( 0.05 μ M , 0.10 μ M , 0.15 μ M ) did not significantly reduce LTB4 release by AM .

甲基强的松龙对伽玛刀照射后胶质细胞Cx43和GFAP表达的影响

The effects of methylprednisolone on expressions of connexin 43 and GFAP in cultured rat astrocytes after irradiation by gamma knife

方法30例择期行双瓣膜置换的病人，随机均分为三组：肝素化膜肺组（H组）、甲基强的松龙组（M组）和对照组（C组）。

Methods Thirty adult patients undergoing elective dual valves replacement were randomly divided equally into three groups : heparin-bonded membrane oxygenator ( group H )、 methylprednisolone group ( group M ) and control group ( group C ) .

实验组予耳缘静脉注射马血清（10ml/kg）2次，每次间隔2周；马血清注射完毕2周后，连续3d腹腔内注射甲基强的松龙（45ml/kg·d）。

The experimental group was given 10 ml / kg of horse serum intravenously 2 times at 2 weeks intervals and an intraperitoneal injection of 45 ml / kg · d of methylprednisolone acetate for 3 days ;

结论：脊髓损伤后脊髓CFos基因表达显著增多，甲基强的松龙能抑制损伤后CFos基因表达。

Conclusion C fos gene expression in rat spinal cord can be markedly enhanced by injury , and MP may play a role in inhibition of c fos gene expression during injury .

结论早期大剂量运用甲基强的松龙，能够抑制失血性休克后肠组织ICAM-1的表达，减轻肠结构的破坏，保护肠粘膜屏障功能。

Conclusion Methylprednisolone can inhibit the expression of ICAM-1 in intestinal tissue and has potential protective effects on the intestinal barrier function after hemorrhagic shock .

结论HBO与甲基强的松龙均可明显抑制T细胞亚群及其粘附分子的表达，且两者具有协同作用。

Conclusions Both HBO and ME prednisolone could inhibit markedly the activities of T lymphocyte and its CAMs expression and besides they have synergetic effect .

目的：探讨甲基强的松龙（MP）对大鼠急性脊髓损伤组织C9，CD59表达的影响。

AIM : To discuss the effects of methylprednisolone on C9 and CD59 expression in rat acute spinal cord injury tissue .

目的：研究大剂量维生素C（VitC）+小剂量甲基强的松龙（MP）对大鼠急性脊髓损伤（SCI）的疗效。

Objective : To investigate the effects of therapy with high-dose Vitamin C ( Vit C ) combined with low-dose methylprednisolone ( MP ) in acute spinal cord injury ( SCI ) .

甲基强的松龙对EAE大鼠脑组织Nogo-A及其受体NgR蛋白的影响

The Expression of Nogo-A and Its Receptor NgR Protein in the Brain of Eae Rat Treated with Methylprednisolone

与静脉应用甲基强的松龙相比，血浆置换使发病时伴有肾衰的ANCA相关性系统性血管炎患者肾脏恢复比例增加。

Plasma exchange increased the rate of renal recovery in ANCA-associated systemic vasculitis that presented with renal failure when compared with intravenous methylprednisolone .