注射给药

应用MATLAB求算静脉注射给药的药动学参数

Calculation of Pharmacokinetic Parameters by Intravenous Injection Based on MATLAB

SAP诱发05h后腹腔注射给药。

Drugs were administered by a single intraperitoneal injection thirty minutes after SAP had been induced .

方法用反相蒸发法制备SOD脂质体，采用黄嘌呤氧化酶法检测SOD活力，静脉注射给药后，测定大鼠血中SOD含量变化和不同组织中SOD含量变化。

Methods The liposomes were prepared by reverse phase evaporation method . The activity of SOD was assayed by method of xanthine oxidase .

复制小鼠Lewis肺癌移植瘤模型，腹腔注射给药10天后检测。

Murine Lewis lung carcinoma transplantation model was made and mice were administrated by intraperitoneal injection for 10 days .

采用尾静脉注射给药的方法，给予SD大鼠不同浓度的Ucn1小时后从胸主动脉取血测血清ACE水平；取大鼠胸主动脉及肺测定组织ACE水平。

One hour after the administration , blood samples were obtained from the thoracic aortas for the determination of serum ACE activity .

方法急性毒性试验为小鼠尾静脉注射给药，测定LD50；

Methods LD_ ( 50 ) of acute toxicity was determined by i.v. in mice .

狗舌草总生物碱LD（50）测定通过改良寇氏法、腹腔注射给药测定总生物碱对KM雌性小鼠的LD（50）。

LD50 Determination of Alkaloids from I Kirilowii The LD50 of total alkaloids was determined using female KM mice by intraperitoneal injection according to improved Karber 's method .

蛋白类药物口服给药易受胃肠道pH值、酶系统及肝脏首过效应等影响导致生物利用度低，临床一般只能注射给药。

The oral administration of protein drugs is easily affected by GI pH value , enzyme system , and first-pass effect , as a result of fraction of bioavailability . Protein drugs are commonly given by injection in clinic .

观察病人30s、40s、50s、60s、四组不同速度静脉注射给药时，对呼吸、循环功能的影响。

The influence respiratory and circulatory function was observed according to time speed of injection 30s , 40s , 50s , 60s .

结果圆窗或心内注射给药后，豚鼠外淋巴液、血浆中的DEX浓度随时间的延长呈逐渐下降的趋势；

Results After topical administration or intracardial injection of DEX , concentrations of drug in perilymph and plasma decreased gradually over time .

目的：观察CO2激光联合卡介菌多糖核酸（BCGPSN）皮损内注射给药预防尖锐湿疣（CA）复发的疗效。

Objective : To observe the efficacy of local injection of bacillus calmette-guerin polysaccharide-nuclear acid ( BCG-PSN ) following CO 2 laser resection on condyloma acuminatum ( CA ) .

【方法】成年金黄地鼠近侧切断视神经（ON），移植一段自体坐骨神经（SN）与ON近侧残端缝接，玻璃体内注射给药。

Optic nerve ( ON ) of adult golden hamster was transected , a segment of autologous sciatic nerve ( SN ) was removed and sutured to the proximal stump of ON .

小鼠口服及腹腔注射给药不同剂量的P2，计算其最大耐受量（MTD）和半数致死量（LD50）。

The maximum tolerable dose ( MTD ) and LD50 of mice were determined after different doses of P2 were given with oral administration and intraperitoneal injection .

用昆明种小鼠尾静脉注射给药观察NHFLE的急性毒性。

The acute toxicity of NHFLE was studied on Kunming species mice .

小鼠腹腔注射给药急性毒性实验（LD50）：设置7个浓度的药液进行腹腔注射，一次给药后观察7d。

The acute toxicity trial in mice , LD 50 was carried out by abdominal injection with 7 dosage groups , and the mice were observed for 7 days after one injection .

在小鼠黑色素瘤自发性转移模型中，鸦胆子油乳25,50100mL·kg-1连续注射给药1个月，小鼠肺转移灶与对照组相比明显减少。

In comparison with control group , the lung metastatic nodes number in the mouse model were significantly decreased after continuously treated with 2.5,5.0,10.0mL · kg - 1 Brucea javanica emulsion oil for a month .

方法15头猪随机均分为3组，分别采用50、100、150mg/kg的硫代乙酰胺进行2次（间隔24h）腹腔内注射给药，观察动物一般情况、存活时间、相关生化指标及病理改变。

Methods General condition , survival time , relevant biochemistry indexes and pathological changes of the pigs treated by two peritoneal injections of thioacetamide in the dose of 50mg / kg , 100mg / kg and 150mg / kg respectively .

方法：96例支原体肺炎（MP）患者随机分为序贯疗法治疗组（A）和全程静脉注射给药组（B），运用药物经济学的成本-效果分析方法进行比较。

Methods : 96 cases of mycoplasmal pneumonia patients were divided into the sequential therapy group ( A ) and the group of intravenous administration in the whole range ( B ) . A comparison was made between these two groups in the way of pharmacoeconomics cost-effectiveness analysis .

皮下注射给药，剂量分别为0.2、2、4、8、16mg／只，进行抑瘤试验。

The hypodermic injection dose was 0 . 2 . 2 . 4 . 8 . 16 mg / mice respectively .

标本制备：两组大鼠于相应时间点前1d以增殖性细胞的标记物5-溴脱氧尿苷50mg/kg腹腔注射给药3次，间隔4h1次。

The preparation of sample : The rats in the two groups were treated with 5-bromium deoxyuridine 50 mg / kg , the marker of proliferation cells , through abdominal cavity for administration 3 times and once every 5 hours one day before the corresponding time point .

但是，如果以游离形式注射给药，达到相似的疗效需要5到10倍浓度的S-ODN。

However , if injected in the free form , a 5 - 10 - fold higher concentration of the S-ODN was necessary to demonstrate a similar efficacy .

于第13d，14d腹腔注射给药。（4）观察各组小鼠诱发皮炎后耳厚度，耳重量，真皮中浸润的炎细胞，小鼠体重的变化。

On day 13 and day 14 . ( 4 ) Effects of various drugs on murine left ear swelling , left ear flake weight , the count of dermal inflammatory infiltration cells and body weight were observed .

缺血前30min经十二指肠注射给药。结扎冠状动脉左前降支60min后，再灌注180min，建立MIRI模型。

Different doses of drug were administered into duodenum 30 min before ligation of the left anterior descending coronary artery ( LAD ) for 60 min and followed with reperfusion for 180 min to establish MIRI model .

结果连续注射给药90d后，大鼠未出现外观、血常规、肝肾功能等血生化及13种脏器组织的毒性变化。

Results After stopping medicine , no abnormal changes of appearance , blood biochemical reaction routine such as routine blood test , function of liver and kidney , and pathological examination of 13 kinds of visceras ' tissue .

AMG162是以静脉注射给药，它的起效机理在于抑制骨母细胞的活性，骨母细胞主要吸收和消除陈骨并给新骨组织腾出空间。

The injectable treatment , called AMG162 , works by suppressing the activity of osteoclasts , the cells involved in absorbing and removing old bone so that new bone tissue can take its place .

目的：研究丝裂霉素-活性碳混悬液（MMC-CH）局部注射给药对腋淋巴结阳性的兔乳腺癌模型的治疗效果。

OBJECTIVE : To investigate the therapeutic effect against tumor-involved axillary lymph nodes in rabbits bearing breast carcinoma with local administration of mitomycin C bound to activated carbon particles ( MMC-CH ) .

经静脉注射给药后，ACMA的血药浓度迅速下降，其分布相（T1/2α）为4.8分钟，消除相（T1/2β）为10.22小时。

The blood level of ACMA decreased very rapidly after iv injection . The distribution phase of ACMA ( T1 / 2 ) was 4.8 minutes , and its elimination phase ( T1 / 2 ) was 10.22 , hr .

结果：与腹腔注射给药方式比较，静脉注射给予ASAC高、中、低剂量后均产生显著抑制肿瘤生长作用，其抑瘤率分别为46.59%、46.31%和32.48%；

RESULTS : Compared with ip , either high , moderate or low dosage of ASAC by iv did have an obvious inhibitory effect on tumor and the tumor inhibition rates were 46.59 % , 46.31 % and 32.48 % respectively ;

结果表明，CS-Cr腹腔注射给药后可使小鼠CFU-S产率和自杀率均明显增高，提示CS-Cr经体内作用可以促进小鼠CFU-S增殖，更多的CFU-S由G0期进入S期。

The results showed that the in vivo intraperitoneal administration of donor mice with CS-Cr remarkably enhanced the production and also suicide rate of CFU-S. This suggests that CS-Cr is able to promote the proliferation of murine CFU-S. by pushing more CFU-S from Go state into S phase .

用小剂量可拉明（0.125g／次）治疗8例急性酒精中毒性昏迷患者，全部病例于皮下注射给药后均迅速苏醒（平均6min），无惊厥、剧烈头痛和肌震颤等毒副反应出现。

Eight patients suffering from acute alcholic coma were treated with low dose coramine . All cases were awaked immediately ( mean 6 minuts ) after 0.125g coramine by subcutaneous injection , no toxic reactions , such as convulsion , severe headache and amyostasia occurred .