格列本脲

治疗4wk和8wk后，格列美脲组空腹血糖改善的总有效率分别为88.2%和100.0%，格列本脲组分别为94.1%和82.4%，2组间差别无统计学意义（P>0.05）。

After treatment for 4 and 8 wk , the total efficacy for Gli was 88 2 % and 100 0 % , and for glyburide was 94 1 % and 82 4 % respectively .

随访期间，罗格列酮组的女性患者骨折发生率明显高于二甲双胍组和格列本脲组。

During that time , women taking rosiglitazone were more likely to have bone fractures than women taking either metformin or glyburide .

格列本脲对巨噬细胞载脂蛋白E分泌的影响

Effect of Glybenclamide on Apolipoprotein E Secretion from Macrophages

二甲双胍格列本脲片中两种成分的离子对HPLC法测定格列美脲与格列苯脲治疗2型糖尿病的临床观察

Determination of two components in metformin hydrochloride and glibenclamide tablets by ion-pair HPLC method

格列本脲对糖尿病及正常大鼠心肌磺脲类药物受体mRNA的影响

Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin induced diabetic rats

目的：建立HPLC方法测定新药复方盐酸二甲双胍片中盐酸二甲双胍和格列本脲的含量。

Objective : To develop an RP-HPLC method for the assay of metformin hydrochloride and glibenclamide in compound metformin hydrochloride tablets .

格列本脲二甲双胍片健康人体药动学和相对生物利用度研究二甲双胍格列本脲片中两种成分的离子对HPLC法测定

Pharmacokinetics and Relative Bioavailability of Metformin-glibenclamide Release Tablets ; Determination of two components in metformin hydrochloride and glibenclamide tablets by ion-pair HPLC method

浙贝乙素胆酸盐+格列本脲处理组的豚鼠抑咳率显著低于浙贝乙素胆酸盐+生理盐水处理组（p0.05）。

The inhibition percentage of cough of Ver-CA + glibenclamide group was significantly lower than that of Ver-CA + saline group ( p0.05 ) .

复方二甲双胍格列本脲片溶出度及生物等效性研究二甲双胍格列本脲片中两种成分的离子对HPLC法测定

Research on Dissolution Rate and Bioequivalence of Glibenclamide and Metformin Compound Tablets ; Determination of two components in metformin hydrochloride and glibenclamide tablets by ion-pair HPLC method

建立了一种简便、快速、灵敏、准确、可靠地鉴定中成药制剂中是否添加格列本脲的高效液相色谱-串联质谱（HPLC＿MS/MS）分析方法。

A method of high_performance liquid chromatography / tandem mass spectrometry ( HPLC_MS / MS ) was developed for the identification of glibenclamide added in Chinese traditional medicines .

二甲双胍和格列本脲均可降低血糖，但二者作用机制不同：格列本脲通过直接刺激胰岛B细胞释放胰岛素，还具有胰腺外降血糖作用；

Metformin and glibenclamide all have the function of lowering the blood glucose level , but the pharmacology are different . glibenclamide depend on the activation pancreatic ( islet ) b-cells that can cause the release of insulin to lower the blood glucose level .

格列本脲可降低SAD大鼠的BPV，并可阻断CPCA降SAD大鼠BPV的作用。

Glibenclamide markedly reduced BPV in SAD rats as well , furthermore , it might antagonize the effect of CPCA on BPV by blocking K ATP .

格列美脲与格列本脲影响KK-Ay小鼠下丘脑神经肽Y分泌的比较研究

Comparison of the effects of glimepiride and glibenclamide on neuropeptide Y secretion from hypothalamus in diabetic KK-Ay mice

此外，下丘脑显性负相Kir2的表达或使用KATP通道阻滞剂格列本脲能抵消OAG的作用减少葡萄糖生成的作用。

Furthermore , hypothalamic dominant-negative Kir6.2 expression or the delivery of the KATP channel blocker glibenclamide abolished the glucose production-lowering effects of OAG .

格列本脲蛋白结合作用的HPLC-FA法研究

HPLC-FA Study on the Protein Binding of Glibenclamide

目的：观察钾离子通道阻滞剂四乙胺（TEA）、四氨基吡啶（4-AP）、格列本脲（Glib）对体外培养SD大鼠前列腺上皮细胞增殖的调节作用。

Objective : To investigate the regulatory effect of potassium channel blocker ( tetraethylammonium [ TEA ] , aminopyridine [ 4-AP ] , glibenclamide [ Glib ] ) on the proliferation of SD rat prostatic epithelial cells in vitro .

Nal和Gli组大鼠在同处理之前，分别静脉注射阿片受体阻断剂-纳洛酮和ATP敏感钾通道阻断剂-格列本脲。

For Nal and Gli group rats , naloxone , an opiate receptor antagonist , and glibenclamide , an ATP sensitive potassium channel blocker , were used injected intravenously 5-minute before preconditioning , respectively .

目的：研究格列本脲（glibenclamide，优降糖）对酰基辅酶A[胆固醇酰基转移酶（ACAT）]mRNA水平的影响，探讨其对ACAT酶的调节水平。

OBJECTIVE To investigate the effect of glibenclamide on expression of acyl-CoA : cholesterol acyltransferase enzyme ( ACAT ) mRNA , and to discuss its regulating level .

目的：建立色谱、质谱、光谱定性和定量分析方法，分析两种CYP2C9酶的底物吲哚美辛和格列本脲在真菌中的代谢产物，探讨采用微生物模型部分替代哺乳动物进行药物代谢研究的可行性；

Objective : Qualitative and quantitative chromatographic , mass spectrometric , spectrographic methods were developed to analyze the metabolites of indomethacin and glyburide in fungi .

建立格列本脲溶出方法。

To establish a method of determine the dissolution of glibenclamide .

重新评估格列本脲（优降糖）最大剂量的初步研究

Re evaluation of the maximal dose of glibenclamide recommended in NIDDM patients

格列本脲对大鼠皮层扩散性抑制中脑血管的调节作用

Regulation of Pial Artery by Glibenclamide During Cortical Spreading Depression in Rats

目的：制备复方格列本脲片。

Objective : To prepare the compound glibenclamide tablets .

格列本脲固体分散体及其复方胶囊剂的研制

Preparation of Glibenclamide Solid Dispersion and Compound Glibenclamide Capsules

比较两种成骨细胞对格列本脲的转运

Biological transport of glybenclamide by two kinds of osteoblasts

羟丙基-β-环糊精/格列本脲包结物的制备及其表征

Preparation and Characterization of Hydroxypropyl - β - cyclodextrin / Glibenclamide Inclusion Complex

目的建立测定消渴平颗粒中格列本脲含量的方法。

OBJECTIVE To establish an HPLC method for determining glibenclamide in Xiaokeping granules .

核苷酸对大鼠心肌[~3H]格列本脲结合位点的影响

Effects of nucleotides on the binding sites for glibenclamide in rat cardiac ventricular membranes

最大剂量格列本脲治疗症状明显的非胰岛素依赖型糖尿病临床疗效观察

Clinical effective observation of maximal dose glyburide therapy in markedly symptomatic patients with NIDDM

目的研究国产复方盐酸二甲双胍片（含盐酸二甲双胍和格列本脲）与盐酸二甲双胍片和格列本脲片的人体相对生物利用度。

OBJECTIVE To determine the relative bioavailability of compound metformin hydrochloride tablets in healthy volunteers .