染色质重塑

染色质重塑在DNA复制、损伤修复和基因转录中发挥着重要的作用。

Chromatin remodeling plays an important role in DNA replication , damage repair and gen transcription .

染色质重塑主要包括2种类型：一种是依赖ATP的物理修饰，另一种是依赖共价结合反应的化学修饰。

Chromatin remodeling is achieved through ATP dependent physical modifications and covalent chemical reactions .

表观遗传修饰主要有DNA甲基化和以组蛋白修饰为特征的染色质重塑。

Epigenetic modification includes DNA methylation and histone modifications .

已有研究表明DNA顺式作用元件与反式作用因子之间的相互作用是染色质重塑和基因转录调节的基础。

Present studies indicate that the interactions between trans-acting factors and corresponding DNA cis-acting elements are the basis of chromatin remodeling and gene transcription regulation .

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

Epigenetic mechanisms , including DNA methylation , histone modification and chromatin remodeling , have been demonstrated to be involved in the development of SLE .

肌动蛋白广泛存在于细胞核中，参与细胞核内的许多生命活动，例如染色质重塑，mRNA加工与输出、基因转录等。

Actin and actin-binding factors have been implicated in nuclear processes , such as chromatin remodelling , mRNA processing and export , and transcription .

并且BAF染色质重塑复合物及其下游Wnt信号和部分心脏发育关键基因的表达也出现下调。

BAF chromatin remodeling complex and its downstream Wnt signaling , heart development related genes were down-regulated .

染色质重塑是基因表达调控过程中一个非常重要的环节.染色质重塑主要包括2种类型：一种是依赖ATP的物理修饰，另一种是依赖共价结合反应的化学修饰。

Chromatin remodeling is an integral part of the process involved in gene transcriptional regulation . Chromatin remodeling is achieved through ATP dependent physical modifications and covalent chemical reactions .

在过去的几年里，人们对表观遗传疾病的机理有了新的认识，这些疾病与染色质重塑、基因组印记、X染色体失活以及非编码RNA调控这4个表观遗传过程相关。

In the past few fears , there has been a nascent convergence of scientific understanding of human disease with epigenetic . Identified epigenetic processes involved in human disease include chromatin remodeling , genomic imprinting , X chromosome inactivation , and noncoding RNAs regulation .

这些染色质重塑因子和转录因子TBP和SP1在小鼠胚胎中时间和空间上的表达是相一致的，说明了这些染色质重塑因子在早期发育过程中对染色质结构和功能起着重要作用。

The expression of these chromatin remodeling factors parallels with SP1 and TBP spatially and temporally , suggesting that remodeling factors play an important role in chromatin structure and function during early development .

一系列实验证据表明，在间充质干细胞的成骨分化过程中，HOX家族基因表达受到抑制，而这种抑制作用是与其分化过程中发生的染色质重塑事件密切相关的。

The data indicated that the genes in HOX family were repressed in the process of hMSCs differentiation , and the inhibition is closely linked with the reprogramming of chromatin .

选取BAF染色质重塑复合物及其信号途径为研究对象，从RNA以及蛋白水平验证分析BAF染色质重塑相关基因及其下游Wnt信号和部分心脏发育关键基因的表达变化。

We focused on BAF chromatin remodeling complex and and its signal pathway , analyzed the gene expression changes of BAF chromatin remodeling related genes , their downstream Wnt signaling and heart development key genes at the RNA and protein levels .

结论：SB使NB4、HL-60、U937细胞核心组蛋白乙酰化程度增加，染色质重塑，有利于CREB等转录因子的活化并与DNA结合，促进CD86转录增强，表达增多。

Conclusion : SB can improve the acetylation states of acute leukemia cells , remodel the chromatin which contributes to the binding on DNA of transcription factors , such as CREB and then promote the transcription and expression of CD86 .

BRG1（brahma-relatedGene1）是进化上高度保守的SWI/SNF染色质重塑复合物的成员之一。

BRG1 ( brahma-related gene 1 ) is a component of the evolutionarily conserved SWI / SNF chromatin-remodeling complex .

首次发现PTEN可以参与染色质重塑，该功能依赖于PTEN蛋白氨基端的磷酸酶活性，C末端（C2结构域、PDZ结构域和C2+PDZ）有抑制作用。

We first find that PTEN can be involved in chromatin remodeling , the function depends on the PTEN protein phosphatase activity of amino-terminal , C terminal ( incluing C2 domain , PDZ domain and C2 + PDZ ) could be an inhibitor in chromation remodeling .

MTA1（Metastasis-associated1）蛋白是一种蛋白复合物，它具有组蛋白脱乙酰基酶的活性，在组蛋白的脱乙酰基，染色质重塑，转录控制的过程中具有重要作用。

MTAl ( Metastasis-associated 1 ) protein is a protein complex with histone deacetylase activity . It plays an important role in histone deacetylation , alteration of chromatin structure and transcriptional control .

染色质重塑和高等植物开花时间控制

Chromatin Remodeling and Flowering Time Control in Higher Plant

局部染色质重塑是多种增殖分化相关基因表达的重要调控机制，组蛋白乙酰化酶和去乙酰化酶是参与该调控机制的两种关键酶。

Local remodeling of chromatin is a key step in the transcriptional activation of genes .

目前有关染色质重塑的研究较少，主要是研究方法的限制。

There are few reports about chromatin remodeling in current researchs , because the research method is the main limitation .

表观遗传是一门新学科，主要研究染色质修饰和染色质重塑等对基因转录表达的调控机制。

Epigenetic regulations mainly involve the mechanism of histone modification and chromatin remodeling regulating gene transcription .