表遗传学

DNA甲基化就是基因表遗传学调节的重要机制之一。

DNA methylation is one of the significant functions of modulation of genetic epigenetics .

表遗传学是研究没有DNA序列变化的、可遗传的表达改变。

Epigenetics is the study of heritable changes in gene expression that occurs without a change in DNA sequence .

表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors .

DNA甲基化是表遗传学上研究最深入的一种机制，是一种酶介导的化学修饰过程，在DNA的某些碱基上增加一个甲基。

DNA methylation , the best understood mechanism in epigenetics , is an enzyme mediated chemical modification that adds methyl ( CH3 ) groups at selected sites on DNA .

表遗传学是研究在DNA序列没有改变的情况下，所发生的可遗传性基因表达的改变，其中DNA甲基化是研究最多、最深入的一种表遗传学表达机制。

Epigenetics is the study of genetic changes in gene expression without the sequence change of DNA , in which DNA methylation is one of the most widely studied epigenetic mechanism .

表遗传学推动新一轮遗传学的发展

Epigenetics Promotes a New Round of the Genetic Development

食管癌相关肿瘤抑制基因的甲基化谱构成了食管癌独特的表遗传学标志；

The special epigenetic biomarkers involved in methylated profile of correlative tumor suppresser genes in EC ;

目的：胃癌的发生发展是一个多基因、多阶段变异积累的复杂过程，涉及到多种基因的遗传学和表遗传学变异。

Purpose : Gastric carcinogenesis is a multistep process of genetic and epigenetic alterations involving many genes .

研究背景：基因功能异常分为两大类机制：遗传学机制和表遗传学机制。

Background : Gene function abnormalities involve two main mechanisms , that is genetic mechanism and epigenetic mechanism .

表遗传学不仅对医学和农业有重要的实践意义，而且还提供了理解遗传和进化的新观点。

Epigenetics not only has practical significance for medicine and agriculture , but also provides new views on understanding heredity and evolution .

我们针对放射状视神经切开术做简单综述。现就表遗传学调控机制与肿瘤发生的关系作一简要综述。

This review summarize the advance in the radial optic neurotomy briefly . Here we briefly summarize the relationship between epigenetic mechanism and tumorigenesis .

由遗传学和表遗传学改变引起的原癌基因的活化和抑癌基因的灭活，是肝癌发生的核心生物学过程；

The activation of proto-oncogenes and the inactivation of tumor suppressor genes induced by genetic and epigenetic alterations are core biological processes of hepatocarcinogenesis ;

研究表明，人类基因组含有两类遗传信息，遗传学信息提供了合成生命所必需蛋白质的模板，而表遗传学信息提供了何时、何地和怎样地应用遗传学信息的指令；

Human genome contains information in two forms : the genetic information provides the blueprint for the manufacture of all the proteins necessary to create a living thing while the epi genetic information provides instructions on how , where , and when the genetic information should be used .

DNA甲基化是白血病表观遗传学改变中较常见的改变。

DNA methylation is a frequent change in epigenetics of leukemia .

DNA甲基化是最常见的表观遗传学改变。

DNA methylation is one of the most frequent epigenetic alterations .

应用表观遗传学方法探索孕妇血浆中胎儿游离DNA

Method of application of epigenetics in maternal plasma of free fetal DNA

病毒SET蛋白对细胞基因的表观遗传学阻遏&一种可能的基因沉默新技术

Epigenetic repression of cellular genes with viral SET protein & a kind of new possible technique causing transcriptional silencing

DNA甲基化&肿瘤产生的一种表观遗传学机制

DNA Methylation : An Epigenetic Mechanism for Tumorigenesis

在真核生物中，DNA甲基化修饰是调控基因表达的一个重要的表观遗传学标志。

DNA methylation is an important epigenetic mark forthe regulation of gene expression in eukaryotes .

DNA甲基化作为一种表观遗传学修饰，是调节基因表达的一种重要方式。

As an epigenetic modification , DNA methylation is an important way to regulate gene expression .

在治疗学上它意味着预防氧化应激可以中止DNA的表观遗传学改变。

Therapeutically , it may mean that preventing oxidative stress may stop epigenetic changes in DNA .

表观遗传学研究那些非DNA序列决定的遗传特性。

Epigenetics examines the inheritance of characteristics that are not set out in the DNA sequence .

表观遗传学：生物细胞非编码RNA调控的研究进展

Epigenetics : advances of non-coding RNAs regulation in mammalian cells

表观遗传学是研究DNA序列没有发生改变的情况下基因表达的遗传变化。

Epigenetics is defined as the investigation of heritable changes in gene expression that occur without a change in DNA sequence .

DNA甲基化（DNAMethylation）是真核生物基因组最常见的一种DNA共价修饰形式，是表观遗传学的一个重要方面。

DNA methylation is a usual covalent modification in eukarya genome and is an important part of epigenetics .

DNA甲基化是表观遗传学修饰的一个重要内容，在早期胚胎发育中起重要的调节作用。

DNA methylation is one of important aspects in epigenetic modifications and plays an important role in regulation of early embryo development .

其中一种表观遗传学因素涉及甲基化过程中被加在DNA上的“分子帽子”。

One type of epigenetic factor they looked at involved molecular caps that are placed on DNA in a process called methylation .

近年来随着表观遗传学研究的兴起，研究者发现DNA甲基化在基因组中含量丰富、分布广泛，并且与年龄之间存在紧密的相关性。

In recent years , learners of epigenetics found that DNA methylation was widely distributed , and had strong correlation with age .

细胞衰老过程中P53表观遗传学修饰

Epigenetic modifications of P53 during cellular senescence

这些研究表明神经激活介导的DNA甲基化状态改变由可能是成体神经系统中一种重要的表观遗传学调控机制。

Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system .