多囊肾病

PPARγ激动剂治疗常染色体显性多囊肾病的实验研究

Experimental Research on the Treatment of Autosomal Dominant Polycystic Kidney Disease with PPAR γ Agonists

肾病综合症小鼠遗传型多囊肾病1基因组片段的克隆

Cloning of mouse polycystic kidney disease 1 gene

应用荧光PCR技术对单个体细胞进行多囊肾病的基因诊断

Genetic Diagnosis of Polycystic Kidney Disease Using Single Cell Fluorescent Polymerase Chain Reaction

目的：探讨免疫抑制药物对成人型多囊肾病（APKD）的治疗作用及其作用机制。

Objective : To discuss the therapeutic effect of immunosuppresant for adult polycystic kidney disease ( APDK ) .

目的：研究特异性分离中国汉族人多囊肾病1型致病基因（polycystickidneydiseasegene1，PKD1）多拷贝区的方法，以排除同源序列对该基因突变检测的干扰。

Objective : To specifically amplify the polycystic kidney disease gene 1 ( PKD1 ) via long range PCR .

与成人多囊肾病PKD2基因紧密连锁的四种微卫星DNA在中国汉族人群中的多态性

Polymorphisms of four microsatellite markers tightly linked with polycystic kidney disease 2 gene in Chinese

ELISA检测囊肿衬里上皮细胞培养上清、多囊肾病大鼠和患者体液中EGF含量。

The quantitative information of EGF in the culture medium of cyst-lining epithelia cells and bodyfluids of ADPKD rats and patients were assayed by ELISA .

常染色体显性多囊肾病（Autosomaldominantpolycystickidneydisease，ADPKD）是最常见的威胁人类健康与生命的遗传性肾病，发病率约为1‰-2‰。

Autosomal dominant polycystic kidney disease is one of the most common human fatal hereditary renal diseases with a morbidity of 1 % o ~ 2 % o.

用与PKD2紧密连锁的微卫星DNA对2型常染色体显性多囊肾病进行基因诊断

Gene diagnosis of autosomal dominant polycystic kidney disease type 2 using microsatellite DNA tightly linked to polycystic kidney disease gene 2

α珠蛋白基因3′HVR在成人型多囊肾病基因诊断中的应用

Usage of 3 ' HVR in gene diagnosis of adult polycystic kidney disease

HMG-CoA还原酶抑制剂对多囊肾病囊肿衬里上皮细胞及成纤维细胞增殖和细胞外基质分泌的影响

Effects of HMG-CoA Reductase Inhibitor on Proliferation and Extracellular Matrix Secretion in Cyst-Lining Epithelial Cells and Fibroblasts of Autosomal Dominant Polycystic Kidney Disease

目的探讨成人型多囊肾病（APKD）症状前诊断。

Objective To study presymptomatic gene diagnosis in adult polycystic kidney disease ( APKD ) .

目的：克隆小鼠的多囊肾病1（PKD1）基因，构建PKD1基因的Knockout载体，为产生PKD1基因缺陷小鼠品系准备条件。

Objective : To obtain mouse polycystic kidney disease 1 ( PKD1 ) gene from a genomic library and construct a knockout vector .

因此，检测PKD1基因的突变是理解多囊肾病分子发病机制的重要步骤。

The search for mutations is one of the most important steps in understanding the molecular mechanisms underlying ADPKD .

2型糖尿病肾病付氧酶的基因多态性目的：检测中国汉族人Ⅱ型多囊肾病基因PKD2的突变。

Objective : To investigate the mutations in polycystic kidney disease gene 2 ( PKD2 ) in the Hans .

目的研究富含半胱氨酸的酸性分泌糖蛋白（SPARC）在常染色体显性多囊肾病（ADPKD）患者体液中的浓度及其分泌来源。

Objective To investigate the concentration of secreted protein acidic and rich in cysteine ( SPARC ) in body fluid of patients with autosomal dominant polycystic kidney disease ( ADPKD ) and the origin of its secretion .

目的：应用表达谱芯片研究常染色体显性遗传多囊肾病（ADPKD）与正常肾组织基因表达的差异，探讨此病的致病因素及可能的治疗途径。

Objective : To study the differential gene expression pattern between autosomal dominant polycystic and normal kidney tissue , and to deduce the etiological factor and treatment for autosomal dominant polycystic kidney disease ( ADPKD ) .

目的研究重组人肝细胞生长因子（rhHGF）对常染色体显性多囊肾病（ADPKD）囊肿衬里上皮细胞增殖的影响及其信号转导途径。

Objective To investigate the effect of recombinant human hepatocyte growth factor ( rhHGF ) on the proliferation of autosomal dominant polycystic kidney disease ( ADPKD ) cyst lining epithelial cells and its signal transduction mechanism .

目的：观察重组人肝细胞生长因子（rhHGF）对常染色体显性遗传性多囊肾病（ADPKD）囊肿衬里上皮细胞合成细胞外基质（ECM）、基质金属蛋白酶及其抑制剂的作用。

Objective : To study the effects of recombinant human hepatocyte growth factor ( rhHGF ) on the synthesis of extracellular matrix ( ECM ) and matrix metalloproteinases and tissue inhibitor of metalloproteinases in autosomal dominant polycystic kidney disease ( ADPKD ) cyst lining epithelial cells .

目的：研究角质细胞生长因子（KGF）对常染色体显性多囊肾病（ADPKD）囊肿衬里上皮细胞细胞周期及其调控蛋白的影响，以初步探讨ADPKD囊肿发生、发展的细胞学机制。

Objective : To investigate the effect of keratinocyte growth factor ( KGF ) on the cell cycle and regulatory protein of cyst-lining epithelia in autosomal dominant polycystic kidney disease ( ADPKD ) and explore the role of KGF in the ADPKD pathogenesis and development .

成人多囊肾病肉眼血尿的临床意义

Clinical significance of gross hematuria in autosomal dominant polycystic kidney patients

Ⅰ型常染色体显性遗传多囊肾病基因诊断与基因突变情况的调查

The gene diagnosis and mutation survey of autosomal dominant polycystic kidney

常染色体显性遗传性多囊肾病研究的热点问题

Hot issues in current research of autosomal dominant polycystic kidney disease

常染色体隐性遗传性多囊肾病：临床、病理与影像学表现

Autosomal recessive polycystic kidnay disease : clinical , pathological and radiological correlations

多囊肾病囊肿衬里上皮细胞增生与凋亡的研究

Studies of proliferation and apoptosis in ADPKD cyst - lining epithelial cells

免疫抑制药物对多囊肾病治疗作用的探讨

Therapeutic effect of immunosuppressant for adult polycystic kidney disease

七个成人型多囊肾病家系基因的诊断多囊型（6例）；

Gene Diagnosis of 7 APKD Families 2.polycystic type ( in 6 cases );

271例常染色体显性遗传性多囊肾病患者临床分析

Analysis of clinical characteristics of 271 patients with autosomal dominant polycystic kidney disease

成年型多囊肾病家系成员的症前基因诊断

Presymptomatic gene diagnosis of adult polycystic kidney disease family

多囊肾病178例的遗传家系调查

Pedigree study of 178 patients with polycystic kidney disease