极性表面积

用极性表面积和分子体积预测药物对血脑屏障的穿透性英文

Predicting blood-brain barrier penetration of drugs by polar molecular surface area and molecular volume

之前有研究发现渗透剂对蛋白质的稳定能力与它的分子表面的极性基团表面积比例呈反比关系，但忽略了分子体积所代表的空间位阻效应的影响，因此存在一定误差。

There was a research before which found that the osmolyte stabilizing effect have negative correlations with the ratio of polar group surface area of their molecules . However , it failed to consider the molecular volume which could represent the steric exclusion effect , therefore had some deviations .

为了解决脂肪酶在离子液体中的溶解问题，使用非极性、高比表面积的无定形多孔硅胶YWG-C6H5对脂肪酶进行了固定化。

To prevent the dissolving of lipase in ionic liquids , a nonpolar amorphous multiporous silica YWG-C_6H_5 with a high specific surface area has been used as the support to immobilize the lipase .