杂合性缺失

目的：探讨微卫星DNA杂合性缺失与急性淋巴细胞白血病（ALL）的相关性。

Aim : To explore the relationship between loss of heterozygosity ( LOH ) of microsatellite DNA and a-cute lymphoblastic leukemia ( ALL ) .

肝细胞肝癌细胞p53基因第2～3,4,11外显子纯合性缺失、杂合性缺失的分析

Homozygous deletion and loss of heterozygosity of p53 gene exon 2 ~ 3 , 4 and 11 in human hepatocellular carcinoma

B细胞淋巴瘤微卫星不稳定性及杂合性缺失的研究

The study of loss of heterozygosity and microsatellite instability in B-cell lymphoma

循环DNA杂合性缺失作为肿瘤标志物在肺癌诊断上的应用

Analysis of Circulating Tumour DNA in Plasma to Diagnosis Lung Cancer

PCR一SSCP变性聚丙烯酞胺凝胶电泳检测PTEN杂合性缺失。

PTEN LOH : PCR - SSCP denaturing PAGE gel electrophoresis and sliver staining .

结果发现：p53基因杂合性缺失率为34.0%（16／24）；

P53 gene was found to be partially deleted in 34.0 % ( 16 / 47 ) of breast cancer tissues .

乙基亚硝基脲诱导小鼠淋巴瘤细胞tk基因杂合性缺失

Loss of heterozygosity of TK gene in mouse lymphoma cells induced by ethylnitrosourea

方法：采用PCR及微卫星多态性技术，对65例肝癌1号染色体上28个微卫星标志位点杂合性缺失进行检测。

Methods : LoH of chromosome 1 were detected by PCR based microsatellite polymorphism analysis technique using 28 pairs of microsatellite markers primers in 65 HCC .

软组织平滑肌肉瘤染色体3p位点特异性的杂合性缺失

Specific loss of heterozygosity of chromosome 3p loci in soft tissue leiomyosarcoma

用微卫星位点进行杂合性缺失（LOH）分析。

LOH analysis was undertaken by using microsatellite markers .

乳腺癌与癌前病变的微卫星不稳定性与3p杂合性缺失

Microsatellite instability and allele-specific chromosome 3p deletion in breast cancer and precancerous lesions

目的探讨6号染色体长臂的杂合性缺失（LOH）与膀胱肿瘤的关系。

ObjectiveTo investigate the loss of heterozygosity ( LOH ) on6q in bladder tumor .

29例乳腺癌中有20例乳腺癌有p53基因杂合性缺失（LOH），缺失率为69%。

Twenty out of 29 ( 69 % ) tumors showed the loss of heterozygosity ( LOH ) in p53 gene .

目的：探讨染色体3p区域多个等位基因位点的杂合性缺失（Lossofheterozygosity，LOH）与乳腺癌发生发展之间的相关性。

Objective : To investigate the frequency of loss of heterozygosity ( LOH ) at several 3p regions in breast cancer tissues .

胃粘膜细胞系GES-1和MC微卫星DNA不稳定性及杂合性缺失研究

Studies of microsatellite instability and loss of heterozygosity in human gastric epithelial cell lines ( ges 1 and mc ) at different passages and carcinogenesis stages

结论在中国人散发性结直肠癌中，MMR基因通过等位基因杂合性缺失是结直肠癌发生的重要分子遗传途径之一。

Conclusions The inactivity of MMR genes by LOH contributes to the carcinogenesis of sporadic colorectal cancer in Chinese patients .

浸润性乳腺癌及乳腺增生细胞3p、9p上5个微卫星位点的杂合性缺失观察

Loss of heterozygosity of microdissected invasive on 3p , 9p in ductal carcinoma of breast and hyperplastic breast lesions

胶质母细胞瘤染色体10q杂合性缺失的初步研究

A Primary Study of Loss of Heterozygosity on Chromosome 10q in Glioblastoma

急性白血病7q杂合性缺失和微卫星不稳定性研究

Study of Loss of Heterozygosity and Microsatellite Instability on Chromosome 7q in Acute Leukemia

将染色体13q末端的微卫星位点作杂合性缺失（LOH）分析。利用微卫星分析家兔遗传多样性

LOH analysis was tested by using microsatellite markers . The Genetic Diversity of Rabbit Using Microsatellite DNA Makers

人肝癌p57~（kip2）基因表达缺失与杂合性缺失的关系研究

The Relationship between the Loss of Heterozygosity and Loss of Expression of p57 ~ ( kip2 ) mRNA

急性粒细胞性白血病7q染色体杂合性缺失研究

Study of loss of heterozygosity on long arm of chromosome 7 in acute myelogenous leukemia

目的研究肝癌全基因组等位基因杂合性缺失（LOH）及其临床意义。

Objective To investigate genome wide loss of heterozygosity ( LOH ) and its clinical significance in primary hepatocellular carcinoma ( HCC ) in southern China .

散发性肾癌中VHL基因的两个单核苷酸多态位点分析和杂合性缺失检测

Analysis of two single nucleotide polymorphisms in von Hippel-Lindau gene and detection of loss of heterozygosity in Chinese sporadic renal cell carcinoma

少突胶质细胞肿瘤染色体1p、19q和10q杂合性缺失与临床预后的关系

Relationship between loss of heterozygosity on chromosome 1p , 19q and 10q and clinical prognosis in oligodendroglial tumors

目的定位儿童急性淋巴细胞白血病（ALL）杂合性缺失（LOH）的集中区域，探索新的肿瘤抑制基因。

Objective To locate the cluster region of loss of heterozygosity ( LOH ) in children with acute lymphoblastic leukemia ( ALL ), and explore the new tumor suppressor gene .

原发性胃癌中19p部分微卫星多态位点杂合性缺失分析

Analysis of loss of heterozygosity on 19p in primary gastric cancer

OLIG1对人少突胶质细胞瘤鉴别诊断意义的实验研究变性高效液相色谱检测少突胶质细胞瘤1p杂合性缺失

Experimental Study on the Distinct Diagnostic Significance of OLIG I to Oligodendroglial Tumors ; Identifying 1p LOH in Oligodendroglioma with Denaturing High Performance Liquid Chromatography

目的：分析鼻咽癌（NasopharyngealCarcinoma，NPC）全基因组染色体杂合性缺失（Lossofheterozygosity，LOH），定位NPC发生高频率LOH的区域，为定位NPC相关基因提供分子遗传学依据。

Objectives : To analyze the genome wide loss of heterozygosity ( LOH ) and to localize the high frequent LOH regions in nasopharyngeal carcinoma ( NPC ), in order to provide molecular genetic evidence for localizing NPC related tumor genes .

建立了一个瘤细胞标本纯度参照体系，以降低标本不纯对抑癌基因杂合性缺失（LOH）研究的影响。

To avoid the interference of sample purity with the study of loss of heterozygosity ( LOH ) affecting tumor suppressor gene , we set up a ladder-like purity frame of reference .