新型疫苗

目的：研制抗结核的新型疫苗（DC疫苗）。

Objective : To develop novel vaccine ( DC vaccine ) against tuberculosis .

正因为如此，F蛋白已经成为研究新城疫基因工程疫苗和DNA疫苗等新型疫苗的首选抗原。

Therefore , it is considered as the most predominant antigen in the vaccine including genetic engineering vaccine and DNA vaccine .

DNA疫苗&跨入21世纪的新型疫苗

DNA vaccines : the new vaccines striding into the 21st century

核酸疫苗（DNA疫苗）是20世纪90年代发展起来的一种新型疫苗。

Nucleic acid vaccine ( DNA vaccine ) has been a new vaccine since 1990s .

基因工程疫苗的研究表明重组疫苗和DNA疫苗等新型疫苗具有较好的应用前景。

The research in genetically engineering vaccine shows that the recombinant and DNA vaccines have a better practical perspective .

很多传统疫苗如果没有佐剂作用，其免疫效果受到极大影响，特别是对一些新型疫苗（如DNA疫苗）的研发或改进，有效佐剂是一个重要的突破点。

The immune effects of some traditional vaccines would be weak without adjuvant . Effective adjuvant is an important breakthrough especially for some new or improved vaccines .

本文对脂质体这种新型疫苗佐剂兼载体与DNA的结合方式、在DNA疫苗中的免疫佐剂作用、脂质体DNA复合物的转染及影响因素等方面作了比较详细地阐述。

This review expounds the combination way of liposome and DNA , effects of immunoadjuvant of liposome in DNA vaccine , and transfection of liposome - DNA complexes .

DNA疫苗作为最有发展潜力的新型疫苗策略之一，可以有效的诱导细胞免疫反应及体液免疫反应，同时可以诱导长期免疫记忆。

DNA vaccine as one of the most potential new vaccine strategies , could not only induce cellular and humoral responses efficiently , but also induce long-time immune memory .

P1为口蹄疫病毒的抗原结构，是研究口蹄疫免疫机制和新型疫苗的基础。

P1 is the antigenic structure of FMDV and is the other researching focus .

目的采用长链RTPCR技术扩增登革2型及4型病毒基因组全长cDNA，为构建登革病毒全长cDNA克隆、表达，深入阐明致病机理及探索新型疫苗奠定基础。

Objective Construction of full length cDNA clone with long RT PCR for elucidating the pathogenesis of dengue virus and developing novel vaccine .

另一方面便是能够研制出预防并且能够治疗H.pylori感染的新型疫苗。

The other is to explore the vaccines for treatment and prevention of H.pylori .

鱼用疫苗的种类繁多，除传统疫苗之外，新型疫苗包括合成肽疫苗、DNA疫苗、活载体疫苗、基因缺失疫苗等。

There are a variety of fish vaccines . In addition to traditional vaccines , new vaccines include synthesis peptide vaccine ,, DNA vaccine , gene defect vaccine , and so on .

本试验揭示试验Ⅰ组对不同血清型APP攻击能够提供很好的交叉保护作用，从而为猪传染性胸膜肺炎新型疫苗的研制提供参考。

So , Trial group ⅰ could provide better crossing protection , which will provide a reference for the development of new vaccine .

DNA疫苗是继减毒疫苗、灭活疫苗、亚单位疫苗和重组多肽疫苗之后的又一新型疫苗，比其它疫苗高效、安全且易于大量生产。

DNA vaccine is a new vaccine after live attenuated , whole killed , subunit and recombinant one , etc. It 's better than them at efficiency , safety and ease to produce .

JEV分子生物学与新型疫苗研究进展

The Advances on Molecular Biology and New Vaccines of Japanese Encephalitis Virus

因此，猪瘟病毒E2蛋白是开发猪瘟新型疫苗、诊断试剂及研究猪瘟病毒致病机理的重要蛋白分子。

It is often used in developing new type vaccines , clinical diagnostic reagents and studying immunopathological mechanisms of the virus .

RNA病毒反向遗传学的发展极大地推动了RNA病毒的分子生物学研究和新型疫苗的开发。

It has greatly promoted the study of RNA viruses at the molecular level and the development of new vaccines since the establishment of reverse genetics of RNA viruses .

而正链RNA病毒的反向遗传操作系统在病毒复制、致病机制研究，抗病毒药物筛选和新型疫苗、导向载体制备等方面是一个极其有用的工具。

Positive-strand RNA virus reverse genetics system is an useful tool in viral replication , pathogenesis research , screening antiviral drugs and new vaccines , vector-oriented areas such as the preparation .

病原分子生物学与致病机理的研究是新型疫苗设计和开发的基础，对APP感染过程相关基因进行研究是非常必要的。

Investigations on molecular pathogenesis are the bases of design and development of new vaccines . Hence , it is essential to identify the genes associated with infection of APP .

复制型DNA疫苗是基于常规DNA疫苗和RNA复制子疫苗的基础上发展起来的一种新型疫苗，既具有稳定性好、安全性高的优点，又实现了外源基因的高效表达。

Replicative DNA vaccine , based on conventional DNA vaccine and RNA replicon-based vaccine , is a kind of new vaccine . It not only has high stability and security , but also has high level of heterologous gene expression .

流感病毒分A、B、C三型，对其病毒学、流行病学和临床特征，以及流感病毒传统疫苗灭活疫苗和新型疫苗核酸疫苗的研究进展作了论述。

There are several differences in the biological and biochemical properties among three types of influenza virus . The virological , epidemiological and clinical features of influenza A , B , and C viruses , the development of influenza vaccine and DNA vaccine were summarized .

因此，迫切需要更安全、高效、廉价的新型疫苗来预防和控制PRRS的发生与流行。

Therefore , it is urgent to develop safer and more effective and cheap novel vaccines to prevent and control PRRS .

PERTH研究人员正在测试一种新型疫苗能保护儿童免遭在澳大利亚西部最常见脑膜炎双球菌类型的倾袭。

PERTH researchers are trialling a new vaccine that could shield children from the most common form of meningococcal disease in Western Australia .

据NPR新闻的理查德·诺克斯报道，联邦监管机构已批准了一款新型疫苗，这种疫苗可以不采取在卵细胞中生长流感病毒的方法。

NPR 's Richard Knox reports federal regulators have approved a new type of vaccine that avoids the need to grow the flu virus in eggs .

由于兔病毒性出血症（RHD）组织灭活苗涉及的成本、生物安全及动物福利等问题，国内外学者正致力于RHD新型疫苗的研制和开发。

Researchers are engaging in studying of Rabbit Hemorrhagic Disease ( RHD ) new type vaccine due to the cost , biology safety and animal welfare of RHD tissue inactivated vaccine .

一旦病毒造成孕妇生殖器疣和呼吸道乳头状瘤，新型疫苗可以预防HPV病毒感染腹中胎儿。

Now In the new vaccines , they also prevent other HPVs , once they cause genital warts and papillomas of respiratory track and papillamas in the respiratory track of young children born into women with genital warts .

这些结果不仅为进一步研究DCs对FMDVVP4抗原的提呈途径打下了基础，而且为新型疫苗设计与开发提供理论指导。

These results not only lay a foundation for further study the antigen-presenting pathways in DCs for FMDV VP4 protein antigen , but also provide theoretical guidance for the design and development new vaccines .

RNAi是一种行之有效的基因沉默的新方法，越来越广泛地应用于基因功能的研究、疾病的治疗以及新型疫苗的研制等领域。

As a method for silencing of gene expression , RNAi is more simple and convenient compared with gene targeting . RNAi has been applied universally in research on gene function , treatment of disease and vaccine production .

近年来兴起的逆向遗传研究将RNA病毒的基因组转化为cDNA，文章就猪瘟病毒逆向遗传研究的意义、方法、概况及其在猪瘟新型疫苗研究中的应用进行了全面综述。

The reverse genetics could translate the RNA into cDNA , it extremely promoted the study on RNA viruses . The significance of reverse genetics , its study method , the advance and its application in the study of on new vaccine were synthetically summarized in this article .

目的：研究我国登革2型病毒43株（D243）基因组全长cDNA体外RNA转录物的感染性，为进一步阐明登革2型病毒的致病机制及探索其新型疫苗奠定基础。

Objective : To study the infectivity of the in vitro RNA transcript of the genomic full length cDNA of strain 43 of Chinese dengue 2 virus ( D2 43 ), and hence to provide the basis for elucidating the molecular pathogenesis of dengue virus and developing novel vaccines .