抑制突变

结论：灵芪胶囊对H（22）荷瘤小鼠有明显抑瘤作用，其机制可能与抑制突变型p53基因和bcl-2基因表达有关。

Conclusion : Lingqi-capsule can obviously inhibit mice sarcoma H_ ( 22 ) . The mechanism of action is correlation of p53 and bcl-2 gene expression decrease .

结论PD可有效降低肺动脉压，延缓大鼠CHPH进程，其机理可能与抑制突变型p53基因表达及细胞增殖，从而有效抑制肺血管重建有关。

It may be related to the inhibition of p53 which can enhance proliferation and decrease apoptosis , that contribute to postpone the development of pulmonary vascular remodeling .

本研究结果提示，茶多酚对OH和O具有直接清除作用。茶多酚对氧自由基的直接清除作用可能是其抑制突变和抗氧化作用的分子生物学基础。

This results indicated that GTP had direct scavenging effect on O and OH , and the direct scavenging effect of GTP on oxygen radicals may be molecular biological basis of its anti-mutation and antioxidation effect .

当加入1%、5%和10%剂量的茶叶浸出液后，可阻断N－亚硝胺的合成，抑制突变率呈剂量－反应关系。

The formation of N-nitrosamine could be blocked , when 1 % , 5 % and 10 % tea water extracts were added , inhibiting rates of mutation showed dose-reaction relationships .

通过构建更精确的整合酶模型，这技术使未来未来搜寻新的药物分子成为可能，这些新药物分子将能通过稳定病毒蛋白酶的结构来抑制突变病毒的抗药性。

By producing a more accurate model of integrase , the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme , as well .

研究者们希望，通过对该基因突变和相关蛋白结构的深入了解可以开发出有效的药物治疗来抑制突变基因的激活。

The researchers hope that understanding more about the gene 's mutations and the structure of the protein may lead to drug treatments to help ensure that mutant copies of the gene are inactive .

P53肿瘤抑制基因突变分析的技术方法探讨

Analytical and technical consideration of P53 tumor suppressor gene mutation

食管癌前病变P53肿瘤抑制基因突变分析

Molecular pathological studies on the esophageal precancerous lesions : Analysis of P53 mutation

它们通过一种称为遗传漂变（geneticdrift）的过程积累它们的DNA的突变，而且几乎没有抑制这些突变的选择压力。

They accumulate mutations in their DNA by a process known as genetic drift and there are few selection pressures around to curb these mutations .

此法在严紧山梨糖/葡萄糖条件下能强烈抑制arg-13突变株生长，但在斑点试验条件下允许arg-13突变株生长。

This selection strongly inhibits the growth of arg-13 under stringent sorbose / glucose condition but allows arg-13 to grow under spot test conditions .

遗传稳定性与抑制基因突变；

Genetic stability and suppression mutation ;

在1000mg/kg速克灵浸泡的黄瓜片上，敏感菌株受到完全抑制，突变菌株则基本不受抑制。

By soaking the slices with 1 000 mg / kg procymidone , the sensitive strain was inhibited entirely while the mutant was done little .

该药物能够准确的将正确的染色体数目导入每一新细胞，产生非整倍体细胞，能够用于治疗由于肿瘤抑制基因突变导致的肿瘤。

Drugs that inhibit accurate delivery of the right number of chromosomes to each new cell , resulting in aneuploidy , would be used to destroy tumors caused by mutations in the tumor suppressors .

二代拉米夫定的长期应用可以有效地抑制病毒多聚酶突变频繁的HBV发生复制。

Long-term treatment with the second-generation nucleoside analogue lamivudine ( lam ) efficiently inhibits HBV replication with frequent viral polymerase mutations .

由此可见，反义PNA有可能在靶基因区域显著性抑制无义突变。

Thus , it is possible to significantly suppress nonsense mutations within target genes using antisense PNAs .

VHL肿瘤抑制基因及其突变的检测

Identification of tumor suppressor gene and intragenic mutations in the von Hippel Lindau patients

未来，将制备转殖基因植物来证实所选择的基因是否真的会抑制eto1-5的突变性状。

In the future work , Arabidopsis transgenic lines will be generated to confirm the function of selected genes as suppressors of eto1-5 .

现在，在这个阵容中我们又添加了一种新类型抑癌机制：IL25以及其它由正常乳腺细胞分泌的蛋白&IL25与这些蛋白能够杀灭、抑制其邻近突变细胞。

We are now adding a new type of tumor suppression to this list , IL25 and other proteins secreted by normal breast cells that kill or subdue their mutated neighbors .

通过引物设计，在抗脯氨酸反馈抑制耐盐突变菌株9315114的proBA基因重叠区引入一个限制性酶切位点，分别扩增出proB和proA基因，并构建融合的proBA基因。

A restriction enzyme site was inserted in the overlapping region of proB and proA genes from a salt-tolerant mutant of B. subtilis 93151 , and a fusion gene was constructed by cloning proB and proA genes respectively .

血细胞核糖核酸酶抑制因子基因突变分析的方法建立及对宫颈癌患者的检测

Establishment of Analysis of Gene Mutation of Ribonuclease Inhibitor in Blood Cells and Detection in Patients with Cervical Carcinoma

PK/PD参数预测金黄色葡萄球菌感染的疗效和抑制细菌耐药突变的系列研究

Study of PK / PD Parameters to Predict the Efficacy and Inhibition of Resistant Mutation of Staphylococcus Aureus Infection

在抽穗期，突变株系与亲本在中午高光强下受到的抑制相比，突变株系受到的抑制较小，而且在18：00以后几乎能恢复到早上6：00的水平；

Like their parent , the mutant lines also had slight photoinhibition at noon and almost completely recovered after 18:00 at heading stage .

水泥土长短桩能够抑制振动力突变对土压力的影响，降低压力峰值，但是对提高土体强度、增大桩周土体对桩的束缚力作用不明显。

The long-short cement pile can inhibit vibration of the influence of the soil pressure mutations , and reduce pressure peak . But it is not obvious to improve the soil strength , and to increase the force binding of the pile from around soil .

利用抗CTP合成酶反馈抑制筛选胞苷高产突变株

Screening of cytidine-producing mutants based on feedback-inhibition resistance of CTP synthetase

蜂胶抑制诱变剂诱发基因突变及染色体损伤作用的研究

Antagonistic effect of propolis on mutation and chromosome aberration induced by mutagens

二乙基二硫代氨基甲酸钠抑制顺铂的致突变作用

Inhibition of sodium diethyldithiocarbamate on mutation induced by cisplatin

以大蒜匀浆滤液对小鼠进行灌胃处理，能有效地抑制酱油的致突变作用（P<0.05）。

After the garlic juice intragastric administration to the mouse , the mutagenicity induced by soy sauce could be inhibited effectively , the difference being significant ( P < 0.05 ) .

结果表明，大部分蔬菜的丙酮提取物具有抑制SOS反应作用，部分蔬菜的水溶性提取物具有抑制SOS反应作用，抑制不同致突变物引起的SOS反应具有专一性。

The results showed that acetone extracts of most vegetables reveal inhibitory effects on SOS responses , aqueous extracts of some vegetables alos reveal inhibitory effects on SOS responses , and they can specifically inhibit SOS responses induced by various mutagens .