慢性肾小球肾炎

研究表明，在我国慢性肾小球肾炎是导致终末期肾病（ESRD）的首位原因。

Research indicates that chronic glomerulonephritis is the first cause of end-stage renal disease ( ESRD ) in Chinese .

慢性肾小球肾炎（CGN），是由多种病因引起的原发于肾小球的一组临床表现相似，而病理改变不一，预后不尽相同的免疫性疾病。

Chronic Glomerulonephritis ( CGN ), which can be caused by multiple reasons , is a series of immunological diseases with similar symptoms , different patho-manifestations and prognosises .

慢性肾小球肾炎尿胱蛋白酶抑制剂C检测的临床意义

Clinical Significance of Detection of Urine Cystatin C in Patients with Chronic Glomerulonephritis

慢性肾小球肾炎（0.470±0.053）改变不明显（P＞0.05）；

That of the chronic GN ( 0.470 ± 0.053 ) did not obviously change ( P > 0.05 );

背景慢性肾小球肾炎（chronicglomerulonephritis）是由多种原因多种病理类型组成，原发于肾小球的一组疾病。

BACKGROUND Chronic glomerulonephritis is made up of many causes and pathologic types .

慢性肾小球肾炎与HLA免疫遗传强关联

Chronic glomerulonephritis and HLA

目的：探讨血清视黄醇结合蛋白（retinol-bindingprotein，RBP）在慢性肾小球肾炎中的诊断价值。

Objective To explore the value of serum retinol-binding protein ( RBP ) in chronic glomerulonephritis .

本文研究了肺气肿、肝硬化、慢性肾小球肾炎和糖尿病患者的Hp表型分布情况，患者总数为606人。

The phenotypes of haptoglobin from 606 patients were determined , inclu - ding emphysema , cirrhosis of liver , diabetes mellitus and chronic nephritis .

目的探讨尿中转化生长因子β1（TGFβ1）检测在慢性肾小球肾炎诊断中的临床意义。

S : Objective To explore the clinical detection and diagnostic significance of urinary transforming growth factor - β 1 ( TGF β 1 ) in chronic glomerulonephritis .

结果慢性肾小球肾炎尿中TGFβ1的含量较正常组明显增高（P<0.01），而血TGFβ1的变化不甚明显；

Results Level of urinary TGF β 1 in chronic glomerulonephritis increased remarkably compared with control group ( P < 0.05 ), while serum TGF β 1 was not so significant .

方法对94例以原发性慢性肾小球肾炎为根底疾病的ESRF患者和108例健康正常人进行载脂蛋白E（ApoE）基因多态性研究。

Methods ApoE genetic polymorphism was analyzed in 94 patients with ESRF ( those patients had chronic glomerulonephritis ), and 108 normal control .

目的探讨苯那普利治疗原发性慢性肾小球肾炎蛋白尿的疗效与血管紧张素转换酶（ACE）基因多态性的相关性。

Objective To investigate the association between angiotensin-converting enzyme ( ACE ) gene polymorphism with the reducing urinary protein efficacy of benazepril in patients with primary chronic glomerulonephritis .

结论糖尿病肾病对肾小管损害较慢性肾小球肾炎明显，但对肾小球损害不如慢性肾小球肾炎明显。尿RBP、Alb可分别作为早期诊断两种疾病的敏感指标。

Conclusion Renal tubular function has been damaged more significantly in diabetic nephropathy , but glomerulonephritis has been damaged more significantly in chronic glomerulonephritis .

目的探讨内皮素1（ET1）与原发性肾小球肾炎肾功能损害的关系。方法正常对照组15例，原发性慢性肾小球肾炎38例。

Objective To explore the relation of endothelin 1 ( ET 1 ) with renal dysfunction of primary glomerulonephritis .

方法采用半嵌套式RT-PCR方法检测健康人、慢性肾小球肾炎、风湿性疾病以及糖尿病（DM）肾病等进行性肾损害患者尿中WT1基因表达情况。

Methods we detected the expression of the WT1 gene in the urine exfoliate cell of patients with healthy control . chronic glomerulonephritis , rheumatic diseases and diabetes mellitus by using Semi-nested PCR .

结论苯那普利可以改善原发性慢性肾小球肾炎患者的尿蛋白，且降低尿蛋白的疗效与患者的ACE基因型有明显的相关性。

Conclusion Benazepril could decline the rate of urinary protein excretion in patients with primary chronic glomerulonephritis , and significant relationship was observed between ACE gene polymorphism and the reducing urinary protein efficacy of ACEI .

目的基于文献探讨慢性肾小球肾炎（CGN）蛋白尿的中医用药规律。

Objective To explore the rule of Chinese medicine in treating chronic glomerulonephritis ( CGN ) proteinuria on the base of literature .

高教育程度、未婚／失婚、在职、原发病因为慢性肾小球肾炎月糖尿病／高血压和高血红蛋白水平抑）对影响心理健康（MCS）方面较相应组别好；

High educational level , unmarried / divorce , employed , primary disease as chronic glomemlonephritis / non-diabetes / hypertension and high hemoglobin level had significant association with Mental Component Summary ( MCS ) .

方法：应用比色法、酶联免疫法及乳胶凝集法分别检测25例慢性肾小球肾炎CRI患者和28例健康对照组尿NAG、RBP及FDP水平。

Methods : We measured the levels of urinary NAG 、 RBP and FDP of the 25 cases of patients with CRI by use of colorimetry ELISA and latex coagulation test .

IIPC低下的发生率依次为急性肾小球肾炎（83%），肾病综合征（43%），慢性肾小球肾炎（32%）。

The rates of lower IIPC were 83 % in acute GN , 43 % in nephrotic syndrome aam 32 % in chronic GN .

目的探讨伴恶性高血压的特发性IgA肾病（IgANMHT）患者的预后及影响肾存活率的相关因素。慢性肾小球肾炎患者恶性高血压的临床特点和预后

Objective To evaluate the outcome of malignant hypertension secondary to IgA nephropathy ( IgANMHT ) patients . Clinical features and prognostic factors of chronic glomerulonephritis with malignant hypertension

原发病以慢性肾小球肾炎为主（714%）。MHD之前已有高血压，且每次血透前、后伴发高血压次数超过其血透总次数的30%者47例。

The main primary disease was chronic glomerulonephritis ( 71 4 % ) 47 patients were with hypertension before MHD , and the numbers of occurring hypertension before or after every hemodialysis were over 30 % of the total hemodialysis times .

目的：观察大剂量黄芪对慢性肾小球肾炎（CGN）患者血清肿瘤坏死因子α-（TNF-）α、白介素（IL-6）及细胞-6免疫功能的影响。

Objective : To observe the effect of high doses of astragalus membranaceus on serum tumor necrosis factor - αα( TNF - ) , Interleukin-6 ( IL-6 ) and cellular immune function in patients with chronic glomerulonephritis ( CGN ) .

益气养阴清热利湿法治疗慢性肾小球肾炎（气阴两虚证）的临床观察疏风清热利湿方对小儿原发性肾病综合征的疗效及IgE的影响

Clinical Study of Using TCM Therapy Expelling Damp-heat by Boosting Qi and Nourishing Yin to Treat Chronic Glomerulonephritis of Dual Vacuity of Qi and Yin The Clinical Research on the Children with Primary Nephrotic Syndrome with the Shu Feng Qing Re Jie Du Theory of Traditional Chinese Medicine

第Ⅲ类新药黄葵胶囊，不久前已获得国家食品药品监督管理局（SFDA）的审批，主要是由黄蜀葵花的醇提取物组成，广泛用于治疗慢性肾小球肾炎。

' HuangKui Capsule ', mainly composed of A. manihot flower extract , has acquired approval from State Food and Drug Administration ( SFDA ) as class III new drug for treating chronic glomerulonephritis for many years .

慢性肾小球肾炎（CGN），简称慢性肾炎，临床上以蛋白尿、血尿、高血压和水肿为基本表现。其起病方式各有不同，病情迁延，进展缓慢，终至慢性肾衰竭。

Chronic glomerulonephritis , abbreviated to chronic nephritis , hematuria , edema , high blood Pressure as the main clinical manifestation , different onset of ways , protracted , slow progressed , and eventually will be developed to the chronic renal failure .

比较常规血清肾功能检测项目，sRBP与sβ2-MG显著相关（P<0.01），系统性红斑狼疮肾病和慢性肾小球肾炎组sRBP与各项肾功能指标相关性好。

SRBP was significantly correlated with serum β _2-MG ( P < 0.01 ) . Furthermore , sRBP was most closely correlated with other renal indices in systemic lupus erythematosus nephropathy and chronic glomerulonephritis than the others .

方法检测了正常人、慢性肾小球肾炎患者血浆内皮素（PET-1）和24小时尿内皮素排泄量（UET-1），内生肌酐清除率（Ccr）和尿β2微球蛋白（β2-m）。

Methods Plasma endothelin-1 ( PET-1 ) N urinary excretion rate of endothelin-1 ( UET-1 ) . , creatinine clearance ( Ccr ) and urinary excretion rate of 2-microglobulin (β 2-m ) in 27 patients with chronic glomerulonephritis and in 10 normal control were measured .

结果死亡7例，共原发病均为慢性肾小球肾炎性尿毒症；

Patients died of uremia due to chronic glomerulo - nephritis .

慢性肾小球肾炎是常见病、多发病，中草药、西药均有效。

Chronic glomerulonephritis is a kind of common-been and frequently-occurring disease .