基因敲除小鼠

L1CAM基因敲除小鼠的脑局部血流量、ATP含量和蛋白合成率分析

Analysis of focal cerebral blood flow , ATP content and protein sythesis of L1 gene knockout mice

在SR－AI／I基因敲除小鼠，OX－LDL在血浆的清除速率和正常小鼠相同。

Clearance rates of oxidized LDL were equally high in SR-AI / II gene knockout mice .

载脂蛋白E基因敲除小鼠冠状动脉内粥样硬化病灶的研究

Study on the atherosclerotic lesions in coronary artery of apoE gene knockout mice

不同周龄载脂蛋白E基因敲除小鼠肾脏损伤的进展情况

Renal Injury in Apolipoprotein E-Deficient Mice of different ages

不同应激对载脂蛋白E基因敲除小鼠动脉粥样硬化及斑块炎症反应的影响与意义的研究

Effect of Different Type of Stress on Atherosclerosis and Inflammation in Apolipoprotein E Gene Deficient Mice

炎症诱导肝细胞内脂质堆积及载脂蛋白E基因敲除小鼠肪肝形成

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty liver of apolipoprotein E knockout mice

载脂蛋白E及其基因敲除小鼠的研究进展

ApoE and ApoE Knockout Mice

结论套环能加速载脂蛋白E基因敲除小鼠颈总动脉斑块形成。

Conclusions Perivascular common carotid collar placement can accelerate atherosclerotic plaque formation in apolipoprotein E-knock out mice .

化合物48/80对载脂蛋白E基因敲除小鼠主动脉斑块的影响

Effect of Compound 48 / 80 on Thoracic Aortic Plaque in Apolipoprotein E - knock out Mice

ApoE基因敲除小鼠认知功能障碍的Morris水迷宫观察

Cognitive impairment displayed by ApoE knockout mice in the Morris water maze

βB2晶体蛋白基因敲除小鼠模型的建立

Establishment of a β B2 crystallin gene knockout mice model

基于此种现状，本课题拟用化合物48/80探讨肥大细胞脱颗粒与载脂蛋白E基因敲除小鼠主动脉斑块的关系。

Based on the status , compound 48 / 80 and apolipoprotein E-knockout mice were used to investigate the effect of mast cell degranulation on plaque .

这些结果表明Pten基因敲除小鼠骨吸收增加。

These results indicated that disruption of Pten in osteoblasts leads to increased bone resorption .

CD8基因敲除小鼠在（28±3）d时发生免疫排斥反应；

The corneal grafts in CD8 knock out mice were rejected at ( 28 ± 3 ) days .

高脂血症apoE基因敲除小鼠心脏中一氧化氮合酶含量及基因表达

Content and gene expression of eNOS in heart of hyperlipidemia apoE - / - mice

脂联素及其受体在吡格列酮抑制ApoE基因敲除小鼠主动脉粥样硬化中的作用

Role of adiponectin and its receptors in anti-atherosclerotic effects of pioglitazone on ApoE knocked out mice

PTPα基因敲除小鼠坐骨神经纤维的超微结构分析

Ultrastructural Analysis of the Sciatic Nerve in Protein-Tyrosine Phosphatase - α Deficient mice

结论apoE基因敲除小鼠主动脉胆固醇含量与其动脉粥样斑块面积的大小密切相关，是apoE基因敲除小鼠动脉粥样硬化斑块形成的一个重要指标。

Conclusions Aortic cholesterol content was an important index reflecting the atherosclerotic plaque formation in apoE-knockout mice .

IL-22对ApoE基因敲除小鼠脂肪肝抑制作用的研究

Inhibition of nonalcoholic steatohepatitis by IL-22 in ApoE knockout mice

最近的研究表明，COX-2基因敲除小鼠的生殖缺陷主要依赖小鼠的遗传背景，与小鼠的品系相关。

However , it was recently shown that the reproductive defects of COX-2-deficient mice mainly depend upon genetic background of the mouse strains .

炎症对SRA/CD36双基因敲除小鼠肝LDL受体表达的影响

Effects of inflammatory stress on LDL receptor expression in the liver of SRA / CD36 double knockout mice and its potential mechanisms

我们对PACT杂合体小鼠自交子代做了大量的胚胎期追踪分析，发现PACT纯合体基因敲除小鼠在胚胎期6.5至7.5天死亡，胚胎发育停滞，原肠形成失败。

We found the homozygotes died around embryonic days 6.5-7.5 . Mutant embryos were found developmentally retarded and failed to undergo gastrulation .

炎症应激加重CD36基因敲除小鼠肝脏胰岛素抵抗

Inflammatory Stress Induce Insulin Resistance in the liver in the CD36 Knockout Mice

MAOB基因敲除小鼠对神经毒素1-甲基-4-苯基-1,2,3,6-四羟嘧啶（MPTP）具有耐受性。

MAOB gene knock-out mice are resistant to the neurotoxin , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine .

阿伐他汀对高胆固醇血症ApoE基因敲除小鼠肝脏骨桥蛋白表达的影响及其分子机制

The Effects of Atorvastatin on Expression of Osteopontin in Liver of ApoE Gene Knockout Mice with Hypercholesterolemia and Its Molecular Mechanism

在排除了焦虑行为干扰的情况下，高脂饮食的iNOS基因敲除小鼠其空间学习记忆能力仍有一定程度的损伤。

Excluding the anxiety behavior interference , the high-fat diet iNOS knockout mice of spatial learning and memory ability still have a certain degree of injury .

CD36基因敲除小鼠的皮肤伤口愈合

Wound Healing in CD36 Knock-out Mice

研究发现REGγ基因敲除小鼠表现出体型偏小、免疫系统存在缺陷的表型。

Studies have shown that REGy knock-out mice display modest growth retardation and have a deficiency in immune system .

喂高脂饲料的iNOS基因敲除小鼠脑内EBD的浓度与WT-HFC组小鼠比，显著降低。

Fed high-fat diet iNOS gene knockout mouse brain EBD concentration significantly reduced compared with WT-HFC mice .

Lats基因敲除小鼠胚胎玻璃化冷冻的研究

Study on Vitrified Method of Lats Knock-out Mice Embryo