嗜碱性粒细胞

CD63是活化嗜碱性粒细胞的最佳标志；

CD63 was the best marker for activated basophil ;

目的建立流式细胞术（FCM）分析嗜碱性粒细胞活化试验（BAT）的方法并评估其在过敏性疾病诊断中的意义。

Objective To establish the method for analysing basophil activation test ( BAT ) by flow cytometry ( FCM ) and evaluate its clinical significance in the diagnosis of allergic disease .

4种CNS传染性疾病脑脊液嗜碱性粒细胞对比观察：192例

Comparison of CSF basophils in 192 inpatients suffered from one of four CNS infectious diseases

肿瘤坏死因子-α和干扰素-γ对人嗜碱性粒细胞中Toll样受体基因表达的调节作用

Regulatory Effects of Tumor Necrosis Factor - α and Interferon - γ on the Expression of Toll Like Receptor Gene in Human Basophils

目的探讨脑脊液嗜碱性粒细胞（BG）的临床意义。

Objective To study the clinical significance of basophilic granulocyte ( BG ) in cerebrospinal fluid .

方法以CD63/CD203c/CD45抗体组合，建立用FCM分析户尘螨致敏的嗜碱性粒细胞脱颗粒的方法。

Methods The protocol for FCM analysis of basophil degranulation in allergy to dust mite by CD63 / CD203c / CD45 combination was established .

高敏的异位性体质患者嗜碱性粒细胞CD63表达分析：慢性自身免疫性荨麻疹的一种实用的方法

Basophil CD63 expression assay on highly sensitized atopic donor leucocytes-A useful method in chronic autoimmune urticaria

革兰阳性菌肽聚糖对人嗜碱性粒细胞中TLR3、TLR9mRNA的上调作用

Up-regulatory Effect of Peptidoglycan on the Expressions of TLR_3 and TLR_9 mRNA in Human Basophils

另外，研究发现，PACU患者血清活化MC或/和嗜碱性粒细胞的介质不是相同的物质。

In addition , some researchers found that histamine release from basophils and mast cells might not be mediated by the same factor .

目的研究不同刺激物干预对过敏性哮喘产妇新生儿脐血中嗜碱性粒细胞分泌白介素4（IL-4）的影响。

Objective To investigate the effects of various stimuli on interleukin-4 ( IL-4 ) release of umbilical cord blood-derived basophils from neonates of mothers with allergic asthma .

结论CIU患者嗜碱性粒细胞AP-1家族部分因子DNA结合活性的改变，可能为CIU发病环节之一。

Conclusions : Some changes in DNA binding activity of AP-1 of basophils of CIU patients may be important in the pathogenesis of CIU .

通过筛选CIU相关的差异表达基因，构建CIU患者嗜碱性粒细胞差异表达基因文库，从而为探索CIU的发病机制寻找线索。

We built basophil cDNA library after screening CIU related differentially expressing genes . That would provide some useful clues for studying the pathogenesis of CIU .

慢性粒细胞白血病患者体内分离出的形态学认定的嗜碱性粒细胞可能是由一部分真正意义上的嗜碱性粒细胞、一部分的pDC及其它目前尚未得到认识的一部分细胞组成。

Chronic myeloid leukemia in patients with isolated from the morphology that the " basophils " likely to be part of the true sense of the basophils , pDC , and the other part of cells has not yet been recognized .

类过敏反应是通过直接激活肥大细胞（MC）/嗜碱性粒细胞（Basophil）或直接作用于补体系统，使靶细胞脱颗粒释放过敏介质，从而引发局部或系统性的过敏症状。

Anaphylactoid reaction is through activating mast cells / basophils directly or activating the complement system , it makes the target cells degranulated and release allergy mediators , therefore , it can cause local or systemic allergy symptoms .

结果发现CIU患者嗜碱性粒细胞P-c-jun（Ser73）蛋白表达升高，另存在AP-1家族部分因子DNA结合活性的改变，而这些差异可能为CIU的发病机制之一。

The results showed that phospho-c-jun ( Ser73 ) protein expression was increased in CIU patients . There was also some changes in the field of DNA binding activity of AP-1 family factors , and these differences may be one of the pathogenesis of CIU .

对嗜碱性粒细胞脱颗粒试验（间接法）诊断过敏性休克的评价

Evaluation of basophil degranulation test ( indirectmethod ) for diagnosis of anaphylactic shock

具有放大嗜碱性粒细胞激活信号的作用。

Which may be a novel mechanism of amplification of basophil activation signal .

我们对嗜碱性粒细胞脱颗粒表型以及疾病不同状态时疾病的自身抗体进行比较。

We compared the presence of autoantibodies to basophil degranulation phenotypes and to disease status .

本书是关于肥大细胞和嗜碱性粒细胞生物学近期研究进展的很好的综述。

This is an excellent review of current research in mast cell and basophil biology .

慢粒急变嗜碱性粒细胞白血病伴罕见染色体畸变一例并文献复习

Case of CML blastic transformation into basophilic cell leukemia with rare chromosome aberrations and literature review

本书主要是面向对肥大细胞和嗜碱性粒细胞生物学感兴趣的研究者和临床医生。

Discussion is targeted to researchers and clinicians who have an interest in mast cell and basophil biology .

同时，干扰素α治疗慢性粒细胞白血病有效的一个标志就是嗜碱性粒细胞数量的减少。

At the same time , interferon - α is the validity treatment in the chronic myeloid leukemia .

由此提示，嗜碱性粒细胞释放能力是辅助诊断，判定疗效的良好指标。

We suggest that basophil releasability is a good index for diagnosing allergic diseases and evaluating its curative effects .

结果自身血清皮肤试验和嗜碱性粒细胞组胺释放试验的阳性率分别为37.5%和43.75%。

Results The positive rates of skin tests with autologous serum and BHRA were 37.5 % and 43.75 respectively .

嗜碱性粒细胞组胺释放试验检测原发性获得性寒冷性荨麻疹患者血清组胺释放活性

Evaluation of histamine-releasing activity in the sera of patients with primary acquired cold urticaria by basophils histamine release assy in vitro

有动物试验研究发现，单纯从细胞形态学上所认定的嗜碱性粒细胞并不具有目前国际上所认定的嗜碱性粒细胞的分子表型。

Experimental animal studies have found that simply identified by the cell morphology on the basophils do not have molecular phenotype by the current international identified .

那么，慢性粒细胞白血病患者体内异常增多的嗜碱性粒细胞是真正意义上的嗜碱性粒细胞吗？它与体内的浆细胞样树突状细胞有何关系？这正是本课题研究的意义所在。

Well , chronic myeloid leukemia in patients with abnormal number of basophils is the true sense of basophils ? What is the relationship between basophils and plasmacytoid dendritic cells ?

结果致死性哮喘组与非致死性哮喘组、非哮喘对照组比较，其黏膜下层、平滑肌、黏液腺及肺泡中嗜碱性粒细胞均明显升高（均P<0.05）。

Results In fatal asthma , number of basophils was significantly increased in airway submucous layer , smooth muscle , mucous gland and alveoli compared with that in non-fatal asthma and non-asthmatics .

方法自身血清皮肤试验和嗜碱性粒细胞组胺释放试验。要进行血常规、血液化学化验和结核菌素皮肤试验。

Methods Skin tests with autologous serum and basophil histamine-release assay ( BHRA ) were performed . A complete blood count , blood chemistries , and tuberculin skin test should be done .

四结论1.慢性粒细胞白血病患者体内分离出的形态学认定的嗜碱性粒细胞，其含量百分比随着疾病的进展而增加，随疗效的提高而减少。

Chronic myeloid leukemia in patients with isolated from the morphological that " basophils " the percentage of content with the progress of the disease increased , with the progress of effect reduced . 2 .