号外

那家报纸出版号外宣布战争结束的消息。

The paper published an extra to announce the end of the war .

公共图书馆亟需重视号外收藏

The Public Library Should Pay Attention to Collecting the Extra Edition

载脂蛋白H基因7号外显子多态性与长沙地区汉族人脑卒中的相关性

The relationship between apolipoprotein H gene polymorphism and stroke in Changsha Hans

2例有CKIT基因11号外显子杂合性突变。

Of the five cases examined for heterozygous deletion mutation of 11 exon of the c-kit gene two were found positive .

结果（1）空腹C肽：16号外显子c/t基因型、t/t基因型高于c/c基因型，差异存在显著性；

Results ( 1 ) The levels of fasting C-peptide of c / t and t / t genotype of exon 16 were higher than c / c genotype .

目的∶建立从石蜡包埋表皮组织中提取DNA，进行β连环蛋白基因3号外显子聚合酶链反应（PCR）扩增的方法。

Objective To establish a method of extracting DNA from the paraffin-embedded epidermal tissue and examine the amplification of β - catenin gene by polymerase chain reaction ( PCR ) analysis .

结果在20例常染色体显性遗传HSP家系的先证者和10例散发性HSP患者中均未发现异常SSCP条带，第7号外显子直接DNA序列分析亦无异常。

Results No abnormal SSCP bands were found in the 30 individuals and the results of DNA direct sequencing were also normal .

中国人WD基因第14和18号外显子的错义突变

Missense mutations of exons 14 and 18 of Wilson 's disease gene in Chinese patients

PCR-SSCP技术检测2型糖尿病患者脂联素基因3号外显子编码区突变

PCR-SSCP and DNA direct sequencing analysis in detecting mutation in exon 3 coding region of adiponectin gene

Dystrophin基因51号外显子缺失连接片段的克隆和测序

Cloning and Sequencing of Junction Fragment with Exon 51 Deletion of Dystrophin Gene

天津地区先天性巨结肠RET基因13号外显子基因多态性研究

Study of RET Proto-oncogene Exon 13 DNA Polymorphism in Patients with Hirschsprung 's Disease in Tianjin District

这些突变均发生在酪氨酸激酶域的ATP结合域附近，突变为19号外显子上的缺失突变，或18和21号外显子上的替代突变。

The mutations , including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21 , cluster around ATP-binding pocket of TK domain .

spotted:为别人所注意的号外--ChuckBass失去了，一样以前没人知道他也有的东西--他的心。

Gossip girl : spotted -- Chuck bass losing something , no one knew he had to begin with - his heart . -

中国人WD基因12号外显子突变研究

The Study of Mutation in Exon 12 of Wilsons Disease ( WD ) Gene in Chinese Peole

结果：7名MODY家系成员HNF-1α2号外显子上游的内含子均存在一碱基G→A置换，即IVS2nt-42G-A；

Results : IVS2nt-42 G-A was found in the flanking of exon 2 in all seven samples .

散发性早发帕金森病parkin基因1、2号外显子突变的研究

Mutation Detection on Exon 1 and 2 of Parkin Gene in Sporadic Early-onset Parkinson 's Disease

家族性与散发性帕金森病Parkin基因4号外显子突变的差异性研究

Difference study on sporadic Parkinson 's disease and familial Parkinson 's disease in exon 4 of Parkin gene

方法收集10个NIDDM家系的112例基因组（DNA），经多聚合酶链反应（PCR）扩增葡萄糖激酶基因第2～10号外显子，SSCP电泳，硝酸银染色筛查点突变。

Methods 112 samples of genome DNA from 10 NIDDM pedigrees were collected . Exon 2 10 of glucokinase gene were amplified by PCR and screened with SSCP electrophoresis and silver staining .

1个LCDⅠ散发病例在BIGH3基因的第4号外显子发现R124C突变；

A heterozygous mutation of exon 4 in a case with LCD I was discovered which was R124C ;

【方法】多重引物PCR法鉴定缺失型DMD患者，分别克隆46和51号外显子缺失后形成的连接片段，测定连接片段的序列；

Deletion-type DMD patients were examined by multiplex polymerase chain reaction ( mPCR ) . The breakpoints of junction fragments with 46 and 51 exon deletions were cloned and sequenced respectively .

方法：采用常规酚抽提法从外周静脉血提取DNA，应用多聚酶链反应-单链构象多态性分析技术对被试者的早老素1基因第5号和第8号外显子进行突变检测。

METHODS : The conventional phenol extraction method was used to withdraw DNA from peripheral blood , and polymerase chain reaction-single strand conformation polymorphism analysis ( PCR-SCCP ) was applied to detect the mutation of the 5th and 8th exons in presenilin-1 gene .

然后通过PCR的方法分别扩增IDH1基因和IDH2基因的第4号外显子，将PCR产物纯化后测序。

The 4th exon of IDH1 and IDH2 were amplified using polymerase chain reaction method and the DNA sequencing of purified products was applied .

方法采用多聚酶链反应单链构象多态性（PCRSSCP）分析技术对68例SAD患者的PS1基因第5号和第8号外显子进行突变检测。

Methods Mutations in exon 5 and exon 8 of PS-1 gene among 68 patients with SAD were screened by polymerase chain reaction-single strand conformation polymorphism ( PCR-SSCP ) analysis .

结果所有病例PS1基因第5号和第8号外显子的PCRSSCP分析结果均显示两条单链和一条双链，未发现异常泳动，推断没有存在突变。

Results The PCR-SSCP patterns of exon 5 and exon 8 of PS-1 gene among all subjects showed two single strands respectively . No mobility shifts were found .

号外！就在苹果AppleWatch细节即将揭晓的前一周，来自中国的华为抢先推出了自己的智能手表，该产品配备蓝宝石玻璃表镜和不锈钢表带，设计灵感来自一款瑞士钟表。

Surprise ! A week before Apple Inc.unveils details for its watch , Chinese smartphone maker Huawei came out with a digital watch of its own , with sapphire crystal , stainless steel band and the design aspirations of a Swiss timepiece .

因为17号外显子的缺失，位于中间的CC结构域被破坏；而36号外显子缺失导致翻译终止，影响了PH和C2结构域。

Because of the deletion of 17 exon , the middle CC domain was destroyed ; and the deletion of 36 exon resulted the termination of translation , thus affecting the PH domain and C2 domain .

中国人肝豆状核变性基因（ATP7B）第16号外显子的突变特征

The characteristics of mutation of the Wilson disease gene ( atp7b ) exon 16 in Chinese

目的通过对抗肌萎缩蛋白（dystrophin）基因3-5号外显子缺失后连接片段的克隆和测序分析，探讨dystrophin基因缺失的发生机制。

Objective To study the mechanisms of dystrophin gene deletion by cloning and sequencing the junction fragment of dystrophin gene with exons 3 to 5 deletion .

先证者3的GLA基因3号外显子内484位点存在1个错义突变，碱基T被C取代，导致其编码的第142位氨基酸由半胱氨酸变为精氨酸（484T>C，C142R）。

484 T to C transition in exon 3 ( codon 142 ), resulting in replacement of a cysteine residue by arginine ( 484T > C , C142R ) .

急性心肌梗死患者IL-1Ra第2号外显子+8006位点多态性分析

Analysis of polymorphism at position + 8006 in exon 2 of interleukin-1 receptor antagonist in patients with acute myocardial infarction