反义药物

目的在计算机模拟mRNA二级结构与定量构效关系分析的基础上优化反义药物设计。

AIM To optimize the antisense drug design based on the methods of secondary structure prediction of target mRNA by computer and the quantitative structure activity relationship analysis .

目的通过计算机模拟bcl2基因的mRNA二级结构，优化反义药物设计。

AIM The antisense drug design will be optimized based on bcl 2 mRNA secondary structure simulated with computer .

目的：验证mRNA二级结构保守性在反义药物设计中的作用，获得靶向HER-2mRNA的优于已报道阳性药物的序列。

AIM : To study the role of mRNA secondary structure stability in antisense drug design and obtain better antisense candidates against neu / HER-2 / erbB-2 mRNA than previous report .

Bavari的研究组在用埃博拉病毒感染猴子之前和之后都给猴子服用了反义药物。迄今为止，找到一个在人类感染埃博拉病毒之后有效的疗法，被证明是极其困难的。

Bavari 's team gave the antisense drug both before and after they infected the monkeys with Ebola virus .

以往研究对34个针对蛋白激酶C-αmRNA二级结构设计的反义药物（AS-ODNs）进行了定量构效关系（QSAR）分析并得到QSAR方程。

In previous study , a quantitative structure activity relationship ( QSAR ) analysis of 34 antisense oligodeoxynucleotides ( AS ODNs ) targeting protein kinase C α ( PKC α) mRNA was performed and a QSAR equation was obtained .

反义药物作用中的靶二级结构域第1个反义药物&福米韦生

Target secondary structural motif in the action of antisense oligodeoxynucleotides

本文综述了近期反义药物开发与应用的进展。

Recent advances in development and application of antisense drugs were reviewed .

基因肝靶向递送多见于反义药物。

Liver-targeted gene delivery was often seen in antisense drugs .

利用这一技术所研制的药物称为反义药物，通常是指反义寡核苷酸。

By means of M . It usually means antisense oligonucleotides . The usually used W.

反义药物为一种倍受关注、极具广泛活性的基因治疗药物。

Antisense drugs are recognized as an interesting kind of genetic therapeutics with potential wide activity .

结论：计算机辅助药物设计有助于获得体外药效优于ISIS3521的反义药物。

CONCLUSION : Computer aided design was helpful to obtain S-ODN with better in vitro effect than current positive drug .

力求找到最合适的标记方法、最恰当的标记条件。为今后碘标记的反义药物应用于临床奠定实验基础。

We discussed the right labeling method and conditions in order to lay the experiment foundation of the antisense medicament labeled by iodine for clinical application .

对基因药物的研究及应用，基因芯片技术、基因毒素、反义药物等在肿瘤治疗中的应用的研究进展做一综述。

To review the application and development of gene drug in the tumor therapy in several directions such as DNA microarray , gene toxin and antisense drug .

目的筛选高效特异的抗HBV反义核酸药物。

Objective To explore a new specific anti HBV agent .

本文讨论了效果比较肯定的基因疫苗、反义RNA药物、三链DNA药物这三种新型基因药物技术的基本方法。

The techniques and methods of 3 novel gene drugs such as gene vaccine , antisense RNA , triplex-forming DNA have been discussed .

放射性核素标记ASODN是反义显像药物合成的最关键步骤。

It is obvious that labeling the ASODN by radioelement is the most pivotal process .

硫代反义寡核苷酸药物癌泰得的临床前研究

Preclinical Research of Phosphorothioate Antisense Oligonucleotide Named " Cantide "

反义核酸药物与抗肿瘤研究

Antisense Nucleic Acid Drug and Antitumor Research

抗肿瘤反义寡核苷酸药物研究现状和趋势

Progress and prospect of anticancer antisense oligonucleotides

甲氨蝶呤磁性抗癌新药的临床前研究硫代反义寡核苷酸药物癌泰得的临床前研究

Preclinical Study of New Anti-tumor Drug of Magnetic Albumin Microspheres Combining MTX Preclinical Research of Phosphorothioate Antisense Oligonucleotide Named " Cantide "

科学家让四只猴子服用“反义”药物，然后让它们感染埃博拉病毒。“反义”药物是一串遗传物质，被设计用来干扰病毒用于自身复制的蛋白质的表达。

Four monkeys were given the'antisense'drug strands of genetic material designed to interfere with the virus 's production of the proteins it needs for replication and infected Ebola .

反义核酸药物是基因药理学的一个新领域，对于肿瘤、遗传病以及传染病的防治具有重要意义。本文综述了近年来国内外反义核酸药物的研究开发、临床试验以及市场前景等。

As a new territory of genetic pharmacology , antisense nucleic acid drug has been promoting the development of tumor research as well as the study of genetic and infectious diseases .