反义寡聚核苷酸

制备脂质体包裹的~（99m）锝标记c-MycmRNA反义寡聚核苷酸的研究

Preparation of Liposome-mediated ~ ( 99 ) m-technetium-labeled Antisense Oligonucleotides of c-myc mRNA

反义寡聚核苷酸：生理学研究中的新工具

Antisense oligonucleotides : new tools for physiological study

与传统的作用于蛋白质的药物相比，反义寡聚核苷酸作用于RNA。

As compared to conventional drugs that work on proteins , antisense oligonucleotides work on RNA .

硫代反义寡聚核苷酸对HSV的作用及对小鼠HSV角膜炎发病的影响

Effect of phosphorothioate antisense oligonucleotide on HSV and mice HSV keratitis

反义寡聚核苷酸对CVB3蛋白基因表达的抑制作用及量效关系的研究

Antisense oligonucleotide inhibition of coxsackievirus B3 gene expression in HeLa cells and dose-response experiments

硫代反义寡聚核苷酸在线性聚丙烯酰胺-毛细管电泳中的分离行为

Separation Investigation of Antisense Phosphorothioate Oligonucleotides Using Capillary Electrophoresis with Linear Polyacrylamide

保护薇乔缝线携载反义寡聚核苷酸的实验研究

Study on delivering antisense oligonucleotide by Coated Vicryl

反义寡聚核苷酸已成功用于对基因表达的特异性调控与抑制。

Antisense oligonucleotides have been successfully employed to inhibit and modulate specifically gene expression .

内皮素受体A反义寡聚核苷酸抑制大鼠移植血管内膜增殖的作用

The Inhibition of Intima Hyperplasia with Antisense Endothelin Receptor a Oligodeoxynucleotide ( AS-ETA-ODN ) in Rat Arterial Allograft

反义寡聚核苷酸抗柯萨奇病毒感染的研究

The Research on the Anti-S. Aureus . Infection Antisense oligonucleotides resistance to coxsackievirus B_3 infection in HeLa cells

因此，发展能有效提高反义寡聚核苷酸稳定性及其细胞转染率的药物运载系统是目前肿瘤治疗研究的当务之急。

Therefore , suitable drug delivery systems are needed to develop for effectively improving cellular uptake and stability of ASODNs .

目的了解Ⅰ型前胶原基因反义寡聚核苷酸对人增生性瘢痕的作用，探讨增生性瘢痕的基因治疗。

Objective To investigate the effect of antisense oligonucleotide of type ⅰ procollagen on hypertrophic scar and to explore a new gene therapy to hypertrophic scar .

阿片受体及受体后信号转导分子的反义寡聚核苷酸能影响相应阿片受体亚型激动剂的药理作用，其中包括阿片类药物的镇痛及其所致的耐受和依赖。

Antisense oligodeoxynucleotide of opioid receptors and signal transduction molecules were able to influencing the pharmacological effects of opioid agonists including the analgesia , tolerance and dependence .

RNaseH在反义寡聚脱氧核苷酸抑制小鼠白血病病毒表达过程中的作用

Roles of RNase H in inhibition of SRS mouse leukemia virus ( srsv ) expression by antisense oligonucleotides

结果：基因芯片筛选出73个差异表达基因，其中上调基因11个，下调反义寡聚脱氧核苷酸对黑素细胞TYR基因和黑素产量的调控作用

Methods : We designed oligo gene chip with homeobox gene to screen The regulating effect of antisense-S - Oligo on TYR gene expression and melanin production of melanocytes

反义寡聚脱氧核苷酸抑制脑胶质瘤多药耐药基因1的表达

Inhibition of Multidrug Resistance Gene 1 Expression in Glioma by Antisense Oligodeoxynucleotides

端粒酶反义寡聚脱氧核苷酸对人肝癌细胞的作用

The effect of telomerase antisense oligodeoxynucleotides on the growth of hepatoma cell line

目的：观察端粒酶反义寡聚脱氧核苷酸对人胃癌细胞株的作用。

To observe the effect of telomerase antisense oligodexynucleotides on gastric cancer cell line .

结果：端粒酶反义寡聚脱氧核苷酸能诱导人胃癌细胞凋亡，抑制端粒酶活性。

Telomerase activity were detected by TRAPELISA . Results : Telomerase antisense oligodeoxynucleotides acted as a specific growth inhibitor to gastric cancer cell line .

反义ras寡聚脱氧核苷酸对血管平滑肌细胞生物学行为的影响

Antisense ras Oligodeoxynucleotides Influence Biological Behaviors of Rat Aortic Smooth Muscle Cells Stimulated by Basic Fibroblast Growth Factor

已显示反义分子对基因有调控作用，以反义技术组建基因工程反义RNA或人工合成反义寡聚核苷酸，特异性地阻断基因的转录、翻译，可作为高度专一性的基因调控工具。

Antisense molecules can regulate and modify gene expression . By using antisense technology , antisense RNA or artificial antisense oligonucleotides can be made to inhibit or block the transcription and translation of genes . These molecules are highly specific in gene regulation .