凋亡小体
- 名Apoptotic body;apoptosis body
![凋亡小体](../cache/1172801.jpg)
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结果:UK以时间和浓度依赖的方式抑制细胞生长,但未发现凋亡小体,流式细胞技术没有检测到凋亡细胞。
RESULTS : Urokinase decreased the number of viable cells in time and concentration dependent manners . No apoptosis body or apoptotic cells were found by flow cytometry .
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细胞核形成凋亡小体并最终解体。
The nuclear comes into being apoptosis body and disaggregates at last .
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形态学观察可见凋亡小体的形成,琼脂糖凝胶电泳可见凋亡典型的DNA梯带;
And DNA ladder in agarose gel were observed .
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AD脑组织易损区存在着DNA断裂损伤,凋亡小体,染色质凝集及凋亡相关的基因表达改变。
There existed DNA breakage , apoptotic body , chromosome aggregation and the changes of related apoptotic gene expression in the AD brain .
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HL-60细胞凋亡小体体外负载树突状细胞的实验研究
Experimental study on apoptotic bodies derived from the HL-60 cells loading dendritic cells in vitro
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肺组织病理学显示ICH组肺损伤严重,肺充血、出血明显,肺上皮细胞凋亡小体形成。
Pulmonary histopathology of ICH pneumonia revealed serious lung injury , pulmonary congestion and hemorrhage .
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DNA裂解率在照后24小时降至14小时的50%,这可能是内环境中巨噬细胞吞噬凋亡小体所致。
After that the percentage of DNA fragmentation came down to about 50 % of the peak value at 24 hours . It was found that the apoptosis could be induced by high dose irradiation .
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DAPI染色发现细胞核凝集并有凋亡小体产生。
DAPI nuclear staining showed that nuclear condensed and apoptotic bodies produced .
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Hoechst染色证实,经血管生成抑制素和反应停处理后的淋巴管内皮细胞,核周围有凋亡小体。
Hoechst staining showed apoptotic body surrounding the nucleus of LEC after treated by angiostatin and thalidomide .
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结果表明,病毒感染24h后,MDCK细胞产生明显的染色质凝聚,核碎裂及形成凋亡小体等现象。
It shows that marked chromatin condensation and nucleus fragmentation can be easily detected in MDCK cells at 24h post infection .
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NBT还原实验发现部分早幼粒白血病细胞胞奖内出现紫蓝色颗粒,并见到核碎解成染色质小体(凋亡小体)。
Part of the acute promyelocytic leukemia cells appeared indigo granules and apoptosis body in plasma through NBT test .
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在少数感染细胞核内可查见呈晶格状排列或散在分布的人乳头瘤病毒颗粒(HPV)。荧光镜下可见细胞核破碎,裂解为大小不等的凋亡小体;
HPV was found in the nucleus of infected cell . fluorescence microscope showed the nucleus broke into pieces , and cell split into apoptosis bodies in different size ;
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上皮的凋亡小体密度(DAB)峰值均在分裂细胞密度(DMC)峰值之后;
The peak value of density of mitotic cells ( DMC ) all appeared before their peak value of density of apoptotic body ( DAB );
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Tet处理细胞72h后,电镜下可见细胞缩小,核裂解,凋亡小体形成;
When treated with Tet for 72 h , cell shrinkage , nuclear fragmentation and apoptotic body formation were observed under transmission electron microscope .
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TH与Hoechst荧光染色显示,抑制剂组小鼠脑黑质部位有大量阳性细胞核固缩呈不规则形,核碎裂,部分裂解为多个凋亡小体。
TH and Hoechst staining showe that part of a large number of positive nuclei in SN were irregular shrinkage , nuclear fragmentation , some cracking to multiple apoptotic bodies .
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电镜下凋亡小体的呈现以及海马TUNEL阳性呈色反应出现于中度损伤组的各时相点,而轻度和重度损伤组凋亡小体及TUNEL阳性反应的呈现则不明显。
Changes of apoptotic body and TUNEL positive reactions were found in groups of middle at each time point , but which was not obvious in mild or severe groups .
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在0.1mg/mL组形成凋亡小体;
Apoptotic body was at 0.1mg / mL ;
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核染色质凝集,可见凋亡小体。(3)药物血清作用24h对SGC-7901人胃癌细胞有明显的抑制作用,抑制率达47.78%:作用48h抑制更明显,抑制率达61.88%,抑制效应呈时间依赖性。
The serum contained Chinese herbs has evident inhibitory function to the human stomach cancer cell SGC-7901 . after 24h culture , the inhibiting rate is 47 . 78 % .
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TEM观察发现,经1.0mg/mlMat处理24h的细胞出现了胞膜上微绒毛消失,染色质边集、核浓缩、核碎裂,凋亡小体形成。
In result of TEM , microvillus disappear , electron density of cytoplasm is high , large deciduous apoptosis bodies appear after being treated with 1.0mg/ml Mat for 24 houres .
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结果经CAG作用48h后,两种细胞株数量明显减少,形态显示凋亡小体增多;早期凋亡标记AnnexinⅤ明显增高,CD11b表达轻度升高,与CA组比较,结果有显著差异(P<0.05)。
Results After incubation with CAG for 48 h hours , cell number reduced , compared with CA , apoptotic body , Annexin ⅴ increased , the expression of CD11b was slightly increased .
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结果:①实验各组肠上皮凋亡小体数均较对照组高,P0.05,与MMC剂量呈正相关,P0.01。
Results : ① In experimental groups , all the NAB in the intestinal epithelium were higher than that in control groups ( P0.05 ), and there was a positive correlation between the doses of MMC and the NAB ( P0.01 ) .
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结果62例经典型霍奇金淋巴瘤中35例bcl2阳性,在62例非肿瘤性背景细胞中均有凋亡小体,而在HRS细胞仅有10例胞质内见凋亡小体;
Results The H-RS cells of 62 CHL were bcl-2-positive in 35 cases . Apoptosis was found in the non-neoplastic cellular background in all cases but in H-RS only 10 in 62 cases .
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对于单次给药动物模型,腹腔注射不同浓度MLT后60min给予1GyX射线全身照射,12h后采用流式细胞术和荧光分光光度法分别检测胸腺细胞凋亡小体百分率和DNA裂解率的变化;
For single administration of MLT , the apoptotic body percentage ( ABP ) and DNA lytic rate ( DLR ) in the thymocytes were determined with flow cytometry and fluorospectrophotometry , respectively , 12 h after irradiation .
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结果:光镜结果表明,蛴螬(终浓度为4mg/ml)作用于MGC-803胃癌细胞24h后,可见胞核固缩、胞核碎裂、凋亡小体形成等凋亡形态学变化;
Results : The grub extract significantly inhibited the proliferation of gastric cancer cells in vitro , morphologic changes of apoptosis with chromatin margination , karyopyknosis , karyorrhexis , apoptotic body were found by the light scope .
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经50μg/mlLTA作用72h后细胞微绒毛消失,细胞质电子密度加深,出现大量脱落的凋亡小体。
After being treated with 50 μ g / ml LTA for 72 hours , microvillus disappear , electron density of cytoplasm is high and organells is not clear , large deciduous apoptosis bodies appear .
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扫描和透射电镜观察可见各实验组细胞表面微绒毛明显减少或消失、胞膜发泡、细胞固缩和核染色质浓缩边集,并出现凋亡小体,热疗+工SDN组的凋亡细胞数量更多。
With electron microscopy , great changes of cell apoptosis were observed , including microvilli disappearance or reduction , cell shrinkage , chromatin condensation or margination and the presence of " apoptosis bodies " .
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1~10μg/ml丹参酮ⅡA作用72h后,肝癌细胞表现为细胞皱缩、核染色质浓缩、核碎裂、细胞出芽以及凋亡小体形成等凋亡特征性的形态学改变。
After treatment with 1 ~ 10 μ g / ml tanshinone ⅱ A for 72 h , BEL 7402 cell apoptosis with nuclear chromatin concentration and fragmentation as well as cell shrinkage and the formation of apoptotic bodies were observed .
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TUNEL染色结果显示,前列腺癌动物模型经TL给药后,TUNEL染色阳性细胞增多,其核内有棕黄颗粒-凋亡小体,呈小圆形,核浓缩、大量微核体的形成。
TUNEL staining results show that , in prostate carcinoma animals after the TL treatment , positive TUNEL staining cells increase , and there are light brown particles inside the nucleus , and small apoptosis roundlets , nucleus condensation and large amount of tiny nucleuses form .
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可见少量的凋亡小体释放。
See the release of a small number of apoptotic bodies .
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荧光染色查找凋亡小体;
Apoptosis bodies were examined by fluorescent staining .