克罗恩病

CT小肠成像对克罗恩病的诊断价值

Diagnostic Value of CT Enterography in Patients with Crohn 's Disease

针灸对克罗恩病大鼠P物质与神经激肽1受体表达的影响

Effects of Acupuncture and Moxibustion on Substance P and Neurokinin-1 Receptor in Crohn 's Disease Rats

C反应蛋白质与克罗恩病活动性的关系

Correlation of C-reactive protein with activity of Crohn ′ s disease

目的探讨克罗恩病（Crohn'SDisease，CD）的临床类型与术式选择。

Objective To investigate the clinical classification and corresponding surgical treatment of Crohn 's disease .

针灸对克罗恩病大鼠结肠胶原合成及TGFβmRNA表达的调节

Regulation of Acupuncture & Moxibustion on Collagen and TGF β mRNA in Colon of Crohns Disease Rats

目的探讨C反应蛋白质（CRP）评估克罗恩病（CD）活动性的作用。

Objective To investigate the role of C-reactive protein ( CRP ) in evaluating activity of Crohn ′ s disease ( CD ) .

肠结核（IT）和克罗恩病（CD）的鉴别诊断一直是临床难题。

Differential diagnosis between intestinal tuberculosis ( IT ) and Crohn 's disease ( CD ) is always a difficult problem in clinic .

结论：雷公藤内酯醇可抑制IL-1β诱导的克罗恩病肠浆膜纤维细胞ICAM-1的表达。

Conclusion : Triptolide inhibits Il-1 β - induced ICAM-1 expression in SF of Crohn 's disease .

当前克罗恩病（CD）在我国的发病率明显升高，影像学检查是CD诊断和鉴别诊断的重要方法。

The incidence of Crohn s disease ( CD ) is rising these years and imaging detection becomes an important measure for its diagnosis and differential diagnosis .

目的：观察针灸对克罗恩病大鼠结肠Ⅰ、Ⅲ、Ⅳ型胶原蛋白合成及转化生成因子-β（TGFβ）mRNA表达的影响。

Objective : To observe the effect of Acupuncture and Moxibustion on ,, collagens and TGF β mRNA in colon of Crohns disease ( CD ) rats .

CD45在克罗恩病患者血清中的表达

Expression of CD45 in the serum of patients with Crohn 's disease

艾灸对克罗恩病大鼠结肠黏膜MCP-1和IL-8蛋白表达的影响

Influence of Moxibustion on the Expressions of MCP-1 and IL-8 Proteins in the Colonic Mucosa of Crohn 's Disease Rats

背景：由于克罗恩病（CD）发病率呈逐年上升趋势以及人口老龄化的出现，将可能有更多的老年CD患者。

Background : With increase of the incidence of Crohn 's disease ( CD ) and aging of the population , the number of elderly patients with CD is expanding .

结果：IL-1β可诱导克罗恩病肠浆膜纤维细胞ICAM-1表达水平显著升高，而雷公藤内酯醇能显著抑制IL-1β的作用，并呈浓度依赖性。

Results : IL-1 β significantly induced ICAM-1 expression in SFs . And triptolide inhibited the effects of IL-1 β in a dose-dependent manner .

以往研究已经发现，克罗恩病（CD）是RMp/Th1反应类型，而OMp/Th2型则与炎症细胞在局部的聚集有关。

Several other studies reported that Crohn ' disease ( CD ) is classified as RMp / Th1 type response but OMp / Th2 type is associated with inflammatory cells infiltration .

背景：克罗恩病（CD）是一种全胃肠道节段性、全壁层炎症性病变，其病因不明，临床表现多样。

Background : Crohn 's disease ( CD ) is a segmental transmural inflammatory disease of gastrointestinal tract . So far its cause remains unclear , and the clinical manifestations are variegated .

克罗恩病（CD）与遗传、免疫、肠菌等多因素相互作用有关，近年来，随着对CD病理生理学状况了解的加深，许多有效的生物学治疗方法已经应用于CD治疗中。

Crohn disease ( CD ) is related with a complex interplay among genetic , immune and microbial factors . In recent years , many effective biological treatments have been used in CD .

单克隆抗体Infliximab治疗克罗恩病研究进展

Development of Crohn Disease Treatment with Infliximab

背景：克罗恩病（CD）的病因尚不清楚，有研究认为肠黏膜免疫功能异常导致了CD的发病。

Background : The etiology of Crohn 's disease ( CD ) is still unknown . It is believed that altered immunological function of intestinal mucosa contributes a significant role to the pathogenesis of CD .

目的研究人类白细胞抗原（HLA）DRB等位基因多态性与汉族人克罗恩病（CD）的遗传易感性的关系。

Objective To explore the relationship between human leucocyte antigen ( HLA ) - DRB allele polymorphism and genetic susceptibility to Crohn disease ( CD ) in Chinese Hans .

Infliximab治疗难治性克罗恩病并发腹腔脓肿1例

Intra-abdominal abscess develops during infliximab treatment of refractory Crohn 's disease : a report of one case

FQ-PCR检测肠黏膜结核杆菌DNA对肠结核的诊断价值肠结核与克罗恩病的临床鉴别及肠黏膜结核分枝杆菌聚合酶链反应检测的意义

The value of fluorescent quantitative polymerase chain reaction detecting Mycobacterium tuberculosis for the diagnosis of intestinal tuberculosis Clinical features , differential diagnosis and intestinal mucosal TB-PCR for intestinal tuberculosis and Crohn 's disease

目的探讨P物质受体NK1R在克罗恩病的病理生理过程中所起的作用。

Objective To investigate the role of substance P ( SP ) and its neurokinin-1 receptor ( NK-1R ) in the pathophysiologic process of Crohn ′ s disease .

Infliximab是一种嵌合型单克隆抗体，可靶向克罗恩病（Crohndisease，CD）发病机制中起重要作用的促炎细胞因子-人肿瘤坏死因子-α（TNF-α）。

Infliximab is a chimeric ( human-mouse ) monoclonal antibody targeted at human tumor necrosis factor - α ( TNF - α), a proinflammatory cytokine important in the pathogenesis of Crohn disease ( CD ) .

Infliximab是一直接针对肿瘤坏死因子α（TNF-α）的嵌合性单克隆抗体，主要用于治疗克罗恩病及类风湿性关节炎。

Infliximab , an anti-TNF - α chimeric monoclonal antibody , is primarily used in the treatment for Crohn ′ s disease and rheumatoid arthritis .

英夫利昔单抗（Remicade）是第一种抗-TNF药物，它的出现是克罗恩病治疗的一次革命。

The introduction of the first anti-TNF drug , infliximab ( Remicade ), revolutionized the treatment of Crohn 's disease , wrote Dr.

目前已经证实，英夫利昔单抗（一种抗TNF-α的嵌合IgG1κ单克隆抗体）用于克罗恩病肠道并发症的治疗，与其治疗克罗恩病瘘管并发症一样有效。

Infliximab , a chimeric IgG1 kappa monoclonal antibody against TNF-alpha , has been effective in the treatment of enteric as well as fistulous complications of Crohn 's disease .

结果59例中包括胃嗜酸性肉芽肿32例，胃类癌8例，胃血吸虫病8例，胃克罗恩病5例，胃淋巴瘤4例，胃型Behcet病2例。

Results Thirty two cases of gastric eosinophilic granuloma , 8 gastric carcinoid tumor , 8 gastric schistosomiasis , 5 gastric Crohn 's disease , 4 gastric lymphoma and 2 gastric Behcet 's disease were identified .

目的探讨维也纳分类标准是否适用于我国克罗恩病的临床分型，以及抗啤酒酵母抗体（anti-saccharomycescerevisiaeantibodies，ASCAs）的临床意义。

Objective To investigate the possibility to classified Chinese patients with Crohn 's disease by the Vienna criteria and clinical features between subtypes . To investigate the clinical significance of anti-saccharomyces cerevisiae antibodies ( ASCAs ) in Crohn 's disease .

方法除正常组外，其余大鼠采用TNBS灌肠法制备克罗恩病模型，在确定模型成功的基础上，随机分为模型组、隔药灸组与电针组；

Methods The CD rats model was established by TNBS clusis . When the model was established successfully , SD rats were randomly divided into CD model group , herbs-partition moxibustion ( HPM ) group and electro-acupuncture ( EA ) group .