代谢网络

通过部分解释环境压力对代谢流分布的影响，淀粉合成途径与TAG合成途径的竞争，说明代谢网络模型较为可靠。

The reliability of the metabolic network model was proved by the partially explanation of the environmental pressures impact on metabolic flux distribution and the competition between starch and TAG synthesis pathways .

方法所需参数较少，只需给定基于COBRA框架建模的代谢网络化学计量学矩阵和反应可逆性信息即可进行计算。

These methods require few parameters : the stoichiometric matrix of metabolic network modeled by COBRA framework and the reaction reversibility information .

基于Web的代谢网络仿真环境

Metabolic Network Simulation Environment Based on Web

MATLAB是一个应用广泛的工程计算软件，应用于代谢网络的优化，能方便、快捷得到系统的优化结果。

MATLAB is a software of technical computing , which has been used widely in many areas .

DNA改组及基因组改组技术可以加深对代谢网络及其分子调节机制的理解，是对合理代谢设计策略的完善和补充。

DNA shuffling and genome shuffling methods can increase our understanding of metabolic networks and their molecular regulation mechanisms , integrating and complementing rational metabolic design strategies .

通过对代谢网络蝴蝶结结构的进一步研究发现，蝴蝶结的中心结（knot）富集双向连接，并含有一个紧致连接的主核（maincore）。

Our further investigation to the bow-tie structure of metabolic networks suggests that the bow-tie knot ( GSC ) enriches bi-directed links and includes a densely connected main core .

COG分析表明，菌株KNP414编码了丰富的信号转导因子及复杂的糖代谢网络。

Analysis of COG showed that the genome encoded complicated signal transduction and carbohydrate metabolism network .

首先，他们收集了这4种单细胞生物（Hp、金葡、大肠杆菌、酿酒酵母）中关于代谢网络的大量的实验数据；

First they gathered extensive experimental information on the metabolic networks of four different single-celled organisms : three bacteria ( H.pylori , S.aureus and E.coli ) and yeast ( S.cerevisiae ) .

体内炎性代谢网络存在复杂的动态调控机制，有多种致炎因子、细胞因子、环氧化酶、一氧化氮合酶（NOS）和NF-κB等通路参与调控。

The in vivo inflammatory metabolic network has a complicated dynamic regulatory mechanism . A variety of proinflammatory factors , cytokines , cyclooxygenase , nitric oxide synthase ( NOS ), NF-kappa B , and other pathways are involved in the regulation .

其二是应用E-Cell模拟平台对红细胞代谢网络的动力学进行了研究。

The other is dynamic analysis of the network using the E-Cell simulation system of the red blood cell .

本文在分析了胞内EMP途径、HMP途径、TCA循环和生物大分子合成途径之后，基于化学计量平衡方程，构建了B.pumilusSY-6菌株生物合成D-核糖的代谢网络。

Based on BMP , HMP , TCA and other anabolic routes of biological molecules and stoichiometric balance equations , metabolic networks of B. pumilus SY-6 were constructed .

建立产核黄素B.subtilis代谢网络，利用代谢通量分析进一步研究Mn2+和Zn2+对核黄素生产过程中代谢流的影响。建立利用LC-MS分析手段进行产核黄素B.subtilis代谢物组学研究的方法。

The functions of Mn2 + and Zn2 + to riboflavin production were further investigated using metabolic flux analysis . A scheme of metabolomics analysis by LC-MS on B. subtilis was developed .

以山东鲁北EIP的硫元素代谢网络为例进行了深入的案例研究，并在几个工业生态系统和自然生态系统案例之间进行横向比较，研究结果表明方法的有效性。

To validate the effectiveness of these indicators , the sulfur element metabolism network in Lubei EIP was taken as major case study . Comparison among several other natural ecosystem and IES cases were carried out in addition .

本文基于KEGG代谢网络，研究了网络的拓扑结构特征，提出了有效的网络模体识别和功能模块发现算法，进行了系统发生分析研究。

Based on the KEGG database , we analyze the topological properties of metabolic networks , and several effective algorithms are proposed for the detection of motif and functional modules .

至今，这方面的研究主要是将布尔型的转录调控网络和代谢网络COBRA模型进行网络整合，由于布尔网络的特性，调控约束对代谢网络的影响是定性的影响。

So far , such research in this area is focus on the integration of the Boolean transcriptional regulatory network and the COBRA model of metabolic network . Due to the characteristics of Boolean networks , the influence of the regulatory network on the metabolic network is qualitative .

给出了两种方法对叶绿体和蓝细菌的代谢网络进行聚类的结果；

The corresponding clustering results of chloroplast and cyanobacteria are presented .

基于代谢网络变化的中药整体效应评价方法研究

Evaluation of Therapeutic Effects of TCM Based on Metabolic Variations

生物信息学用于代谢网络研究的进展与展望

Progress and perspective in application of bioinformatics to analysis of metabolic networks

人类红细胞代谢网络的建模与模拟

Reconstruction and Simulation of the Metabolic Network of Human Erythrocyte

花生四烯酸代谢网络研究：从关键酶的单靶标抑制剂到多靶标抑制剂

Controlling arachidonic acid metabolic network : from single-to multi-target inhibitors of key enzymes

两株不同体积酵母酿酒过程中的代谢网络分析

Metabolic Network Analysis to Saccharomyces cerevisiae of the Different Size in the Brewage

图形聚类算法的代谢网络模块化分析

Modularization of Metabolic Network Based on Graph Clustering Algorithm

一个基于基因组的大规模代谢网络的基元模式的确定方法

A Method for Determining the Elementary Flux Modes in Genome-based Large-scale Metabolic Network

植物干旱胁迫下的调控代谢网络研究进展

Advances in Regulatory Metabolic Networks in Drought Stress Responses

热力学约束下代谢网络流量的蒙特卡洛采样方法

Monte Carlo sampling of metabolic fluxes under thermodynamic constraints

大规模代谢网络极端途径的计算及可视化研究

The Research of Calculation of Extreme Pathways in the Largescale Metabolic Network and Visualization

代谢网络定量分析研究进展

Progress in the quantitative analysis of metabolic network

这些酶都可能是在蔗糖代谢网络中起关键作用的。

These enzymes all possibly were in the sucrose metabolism network and made key functions .

该模型所揭示的拓扑模式有助于设计专门针对代谢网络的更有效的算法。

The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks .

代谢网络通量和结构分析

Network-based Metabolic Flux and Structure Analysis