代谢组学

Sprague-Dawley大鼠肾脏急性缺血再灌注损伤的代谢组学研究

Metabolomics analysis of renal acute ischemia / reperfusion injury in Sprague-Dawley rats

本文简要介绍了核磁共振波谱技术的基本原理、多维NMR以及在结构鉴定、构象分析、医学临床检测、蛋白质组学、代谢组学等方面的应用。

This article mainly introduces the principle of NMR , multidimensional NMR and their application in structural identification , conformational analysis , clinical check of iatrology , proteomics , metabolomics , and so on .

目的从粪便上清液代谢组学及基因组学探讨类风湿关节炎（Rheumatoidarthritis，简称RA）脾虚证的中医证候实质。

Objective : To study the spleen deficiency syndrome of rheumatoid arthritis from fecal supernatant metabonomics and Genomics of traditional Chinese medicine .

LC/MS/MS结合主成分分析（PCA）用于鼠尿中灯盏花素代谢组学的研究

Application of the Liquid Chromatography Coupled to Tandem Mass Spectrometry with Principal Components Analysis for Metabonomics Studies of Scutellarin in Rat Urine

经前期综合征（PMS）肝气逆证代谢组学研究

Metabonomics Study on Premenstrual Syndrome with Liver-qi Invasion

目的：采用核磁共振（NMR）代谢组学法研究雷公藤多苷片对大鼠代谢的影响。

Objective : To investigate the toxic effects of Glucoside Tripterygium total on rats with nuclear magnetic resonance ( NMR ) - based metabonomic method .

代谢组学数据中的噪音属性很可能会对SVM最优超平面的构建产生影响，进而影响到对特征的评价。

Noise features in metabolomics data are likely to impact the construction of the optimal hyper-plane in SVM . thus can affect the evaluation of features .

CCL4诱导大鼠肝损伤模型的代谢组学及茵陈蒿汤的干预作用研究

Metabonomics of CCL4-Induced Rat Liver Injury and Interfering Effects of the Yin Chen Hao Tang Extract

利用代谢组学技术对功能性消化不良（FD）女性患者血浆中代谢产物的变化进行研究。

Metabonomics was applied to study the changes in plasma metabolites of female patients with functional dyspepsia ( FD ) .

以上结果表明，代谢组学技术能够对FD女性患者血浆中代谢产物的变化进行客观评价。

These results suggested that , changes in plasma metabolites of female patients with FD could be evaluated by metabonomics objectively .

目的：建立测定K562及K562/A细胞内核苷类代谢物含量的高效液相色谱法，用于两者代谢组学研究。

Objective : To establish a reversed-phase ion-pair high-performance liquid chromatographic method for simultaneous determination of nucleotides and nucleosides in K562 and K562 / A cell lines .

基于NMR代谢组学研究显示与正常组相比，痛风组1H-NMR图谱中丁酸、丙酸、乙醇、谷氨酰胺、牛磺酸、葡萄糖等代谢物的谱峰有了明显的改变。

In the metabolomics studies , compared with normal group , butyric acid , propionic acid , ethanol , glutamine , taurine , glucose in the gout group have obviously changed .

气相色谱-质谱联用（GC-MS）是代谢组学研究中常用的分析技术之一，具有分辨率和灵敏度高，取样量少等的特点，并且有可用于快速鉴定代谢物的商业化质谱数据库。

Gas chromatography-mass spectrometry ( GC-MS ) technique is one of the commonly used analysis technics in metabonomics , which is characterized by high resolution and sensitivity , with a commercialized MS database for rapid identification of metabolites .

本研究运用病证结合手段，采用液相色谱-质谱联用（LC-MS）技术的代谢组学方法，以代谢综合征为基础病探讨其脾气虚患者尿液中小分子代谢组成分。

We investigated the small molecular metabolite in urine of Metabolism syndrome patients as the foundation of spleen qi deficiency using method of disease and syndrome with combination and liquid chromatography-mass spectrometry technology .

基于NMR的代谢组学分析方法为探讨GDM的病理机制提供一个很好的技术平台，并将在GDM的早期诊断和个体化治疗等方面的研究具有广阔的应用前景。

Results have shown that the NMR-based metabonomics approach provides a robust technical platform to study the pathomechanism on GDM , and will have broad application prospects in early diagnosis and individual therapy of GDM in the future .

表明利用代谢组学研究尿液中的代谢物，可以为HLP的诊断和发病机制提供一个可借鉴的手段；

It was noted that the research of metabolites in the urine samples may be a useful tool to help diagnose and understand the pathogenesis of HLP .

论文主要是将RJMCMC算法应用于代谢组学的核磁共振信号处理中。

In this paper , a Reversible Jump Markov chain Monte Carlo ( RJMCMC ) algorithm is applied to signal processing of NMR-based metabonomics .

代谢组学（Metabonomics）能够反映细胞、体液的内源性和外源性代谢物浓度与机体功能之间的关系，已在医学、生物学等众多领域得到广泛的应用。

Metabonomics can reflect the relationships between the organism function and concentration of endogenous and exogenous metabolites which in the cells and body fluids , and has been widely used in the research of pharmacology and biological sciences .

而气相色谱-质谱（GC-MS）联用技术具有较强的分离分析能力，灵敏度高，操作简便，而且有商品化的标准质谱数据库，可对代谢物的结构进行快速鉴定，适合于代谢组学分析。

Gas chromatography-mass spectrometry ( GC-MS ) is a better and mature technique with searchable standard database , excellent separating , qualitative abilities with a high sensitivity and easy operation , which facilitates the identification of metabolites . Thus GC-MS considered as an ideal tool is suitable for metabonomics analysis .

中医证候标准化现代化研究与代谢组学方法的应用

Standardization study on syndrome of TCM and the application of metabonomics

龙胆对大鼠尿液影响的代谢组学初步研究

Metabonomics preliminary study on the urine of radix gentianae administrated rats

高血压病阴虚阳亢证的代谢组学研究

Study of Hypertension Yin Deficiency and Yang Excess Syndrome on Metabonomics

代谢组学评价黄连对大鼠药理作用的初步研究

Study of metabonomics on pharmacological action appraisal Rhizoma Coptidis in rats

骨髓增生异常综合征中医证型的代谢组学分析

Metabonomics Analysis of Traditional Chinese Medicine Patterns in Patients with Myelodysplastic Syndrome

基于代谢组学技术的辛伐他汀对磷脂类物质作用的初探

Study the effects of simvastatin on phospholipids by metabonomics-based technique

核磁共振代谢组学数据处理新方法及应用

New Methods of NMR-based Metabonomics Data Processing and Its Application

应用代谢组学方法对细菌培养体中霉菌毒素的研究

Research of Mycotoxin in Bacteria Culture Medium by Application of Metabolomic Method

口腔常见放线菌代谢组学鉴定的初步研究

Initial study on the discrimination of oral common Actinomycetes with metabonomics method

基于代谢组学的热病证候模型评价方法研究

Research on evaluation methods of the fever syndrome model based on metabonomics

去卵巢骨质疏松大鼠血浆~1H-NMR代谢组学分析

~ 1H-NMR-based Metabonomics Analysis of Plasma from Osteoporotic Rats Induced by Ovariectomy