细胞外间质

肝纤维化（hepaticfibrosis）是在肝脏慢性损伤与修复愈合的过程中形成的一种病理改变，细胞外间质（Extracellularmatrix，ECM）的过度合成与沉积是其主要特征。

Hepatic fibrosis is a wound-healing process in livers with chronic injury and is characterized by the excess production and deposition of extracellular matrix ( ECM ) components .

药物治疗包括：光动力学治疗、激素、血管内皮生长因子VEGF的抑制药物、细胞外间质的修饰药物、基因治疗、营养补充和脉络膜血流促进药物等。

The pharmacological therapies include photodynamic therapy ( PDT ), steroids , vascular endothelial growth factor ( VEGF ) inhibitors , extracellular matrix ( ECM ) modifiers , gene therapy , nutrition supplements , choroidal blood flow facilitators and the like .

透明质酸（HyaluronicAcid，HA）又名玻璃酸，是一种广泛存在于高等动物和低等动物细胞外间质中的高分子量聚多糖。

Hyaluronic acid ( HA ) is a extracellular high molecular weight polysaccharides widely present in higher animals and lower animals .

运动训练对肌腱细胞外间质及IGF-imRNA和蛋白表达的影响

Effect of Treadmill Exercise on the ECM of the Tendon and Expression of IGF-I mRNA and Protein in Tendon

液闪探测PMNLy化学发光及其细胞外间质成分改变与肝纤维化关系研究

Study of Liquid Scintillator in Detecting the PMN CL , Ly CL and Extracellular Matrix in Liver Fibrosis

804G细胞外间质对体外培养牛角膜内皮细胞增殖的影响

The effect of extracellular matrix of 804G cells on proliferation of bovine corneal endothelial cells in vitro

结果生长于804G细胞外间质上的牛角膜内皮细胞结合素α6表达增加，酸性磷酸酶活性明显高于对照组。

RESULTS The integrin α 6 of bovine corneal endothelial cells cultured on 804G extracellular matrix was overexpression and activity of acidic phosphatase was significantly higher than control .

细胞外间质研究是一个十分活跃的生物学领域。

Extracellular matrix research is an active field in biology .

胶原蛋白和弹性蛋白是细胞外间质的主要成分，可以作为评估组织生理学和病理学的内源性指标。

Collagen and elastin , as the major components in the extracellular matrix ( ECM ), are intrinsic indicators of physiological and pathological states .

组织工程学家了解到细胞外间质的重要性后，就一直在找寻一种理想的替代品，以做为活体组织生长的基台。

Aware of the importance of extracellular matrix , tissue engineers have long sought an ideal substitute to serve as a platform for growing living tissues .

细胞外间质纤维组织的增生一方面可为胃癌细胞浸润生长提供依托，另一方面也反映了机体对抗和限制肿瘤转移的一种趋势。

The infiltration and metastasis of cancer cells firstly have to break this membranous structure , On the one hand , the hyperplastic fibrotic tissue of extracellular matrix can provide a support for the infiltrative growth of cancer cells ;

目的探讨细胞因子与细胞外间质成份在缺血性股骨头坏死（INFH）疾病发病中的作用。

Objective To study the relation between cellular factor , intercellular substance and pathogenesis of ischemic necrosis of femoral head ( INFH ) .

发现正常人脾内IFNγ呈弥漫性分布，可位于细胞内或细胞外间质，而晚期血吸虫病患者脾内IFNγ仅呈零星散在分布，并且多位于细胞内。

It was found that IFN - γ in the spleen of normal persons was diffusely distributed , either inside the secretory cells or in the extracellular substance . IFN - γ was scattered and mainly located inside the secretory cells in the spleen of patients with advanced schistosomiasis .

MMPS是小胶质细胞分泌的主要蛋白酶类，与多种细胞外间质重塑的正常及病理过程相关。

MMPS is the main protease class of microglia cells secrete , with a variety of extracellular remodeling in normal and pathological processes involved .

然而当细胞定居下来，并开始分泌自己的细胞外间质时，这些支架也会溶解，仅留下健康的组织。

But after the cells have established themselves and begun secreting their own extracellular matrix , the scaffold should dissolve , leaving behind only healthy tissue .

心肌纤维化是高血压发病过程中左室重建的重要病理改变，心脏成纤维细胞（CFs）的增殖和其生物活性决定着心肌细胞外间质胶原的生成和降解，而最终影响心肌肥厚的发生与发展。

The pathological basis of left ventricular hypertrophy include myocytes hypertrophy and cardiac fibroblast ( CFs ) proliferation and excessive collagen synthesis in CFs , which leads to extracellular interstitial accumlation of collagen , and affect the progression of LVH .

两者整体构成相似，均主要由细胞趋化因子、细胞素、细胞生长因子、结合蛋白、细胞外间质修复相关因子等构成。

The overall composition of both was similar , which were mainly chemotactic factor , cytokines , growth factors , binding proteins , and extracellular matrix repair-related factors .

尽管如此，我们还需要观察活细胞是否也认为：这样的支架可以代替梗塞部位所没有的细胞外间质。

Still , it remained to be seen whether living cells would find our scaffold to be an adequate substitute for the missing extracellular matrix in an actual infarction .