亚硝基胍

应用诱变剂亚硝基胍（NG）和紫外线（UV）交替诱变处理法，诱变牛病沙门氏菌S。

Alternatively using mutagenic methods by mutagen Nitrosoguanidine ( NG ) and Ultra violet ( UV ), S. 301 strain of salmonella bovismorbificans was sift out .

当萃取液冷却至0℃时，亚硝基胍结晶析出。

Nitrosoguanidine crystallizes when the solution is cooled to 0 ℃ .

甲基硝基亚硝基胍诱发转化细胞环核苷酸和DNA碱基含量变化的探讨

Studies on the Changes of Cycle Nucleotide and Base Contents in Cells Transformed by MNNG

方法：甲基硝基亚硝基胍溶液加胃粘膜机械损伤诱发Wistar大鼠胃癌前病变状态。

Methods : In animal experiment , precancerous lessions of gastric cancer models were induced by MNNG in wistar rats .

非律平菌素干扰甲基硝基亚硝基胍对FL细胞鞘脂代谢的影响

Filipin Interferes with the Effects of N-Methyl-N ′ - nitro-N-nitrosoguanidine on Sphingolipids Metabolism in Human Amnion FL Cells

方法采用甲基硝基亚硝基胍（MNNG）直肠灌注法对Wistar大鼠每日灌肠，定期取材。

Methods By rectal perfusion , Wistar rats were given MNNG every day , and samples were collected periodically .

用强诱变剂N-甲基-N-硝基-N-亚硝基胍（NG）处理条斑紫菜和坛紫菜的幼嫩叶状体，进行色素突变体诱导。

: The young thalli of Porphyra yezoensis and P. haitanensis are induced by N-Methy-N-Nitro-N-Nitrosoguanidine ( NG ), a strong mutagen to induce the mutant of chromatophore .

本文对7例N-甲基-N′-硝基-N亚硝基胍（MNNG）诱发的大鼠肺未分化癌进行了组织化学和超微结构的研究。

Pulmonary undifferentiated carcinomas in seven rats , induced by MNNG were studied by histochemical and electron microscopic methods .

用吖啶橙消除质粒试验及亚硝基胍回复突变试验，初步证明抗生素抗性基因在质粒上，而决定多粘菌素E生物合成的基因可能在染色体上。

The elimination of plasmid by acridine orange and the reversion test by NTG indicated preliminarily that the gene of biosynthesis of polymyxin E is located on the chromosome , but those antibiotic resistance genes are located on the plasmid .

目的：探讨蛙皮素在化学致癌剂N鄄甲基鄄N'鄄硝基鄄N鄄亚硝基胍（MNNG）诱发人胃黏膜上皮永生细胞系GES鄄1癌变过程中的作用。

Aims : To investigate the effects of bombesin on the malignant transformation of immortalized human gastric epithelial cell line GES-1 induced by chemical carcinogen N-methyl-N ′ - nitro-N-nitrosoguanidine ( MNNG ) .

甲基硝基亚硝基胍诱导的一种全核γH2AX染色的特性研究

A distinct whole nucleus stain pattern of γ H2AX induced by N-methyl-N ' - nitro-N-nitrosoguanidine

用缺锌饲料饲养Wister大鼠，以N-甲基-N硝基-N亚硝基胍（MNNG）作为致癌剂染毒，观察了缺锌对大鼠的危害。

The harms on the Wister rats fed by zinc-deficiency feed were observed when the carcinogenic substance MNNG ( C_2H_5N_5O_3 ) is used .

目的：明确甲基硝基亚硝基胍（MNNG）诱导的全核γH2AX所代表的DNA损伤的性质。

Objective : To characterize the DNA damage property represented by the distinct whole nucleus stain pattern of γ H2AX induced by N-methyl-N ' - nitro-N-nitrosoguanidine ( MNNG ) .

本文用MNNG（N-Methyl-N'-nitro-N-nitrosoguanidine）（甲基硝基亚硝基胍）转化赤麂肺成纤维细胞株（KIZ-7901）。

Lung fibroblast line of Indian muntjac ( KIZ-7901 ) was transformed with MNNG ( N-Methyl-N-nitro-N-nitrosoguanidine ) .

鼻咽癌患者外周淋巴细胞经紫外线或化学致癌剂N-甲基-N'-硝基-N-亚硝基胍（MNNG）处理后，其非程序DNA合成（UDS）值比健康人的为低；

Using UV or MNNG as inducing agents , the UDS values of peripheral lymphocytes from patients with nasopharyngeal carcinoma ( NPC ) were found to be lower than that from normal healthy subjects .

方法采用诱变剂亚硝基胍处理菌种，以含1g·L-1甲硫氨酸的分离培养基作为定向筛选的分离平板，挑选生长快的菌落进行初筛、复筛。

Method NTG was used as mutagen in treating avermectin-producing strain and medium containing 0.1 % methionine was used as separation plate medium to select strains growing fast on such plate .

利用亚硝基胍（NTG）对红霉素链霉菌（S.erythreusUV80）活性菌株进行回复突变，获得了红霉素高产量变株。

The higher yielding strain was obtained through the reverse mutant of a zero producer of Streptomyces erythreus UV 80 by NTG treatment .

目的：分析甲基硝基亚硝基胍（MNNG）诱导的共表达蛋白的编码基因启动子区的转录因子结合部位。

AIM : To find out common transcription factor binding sites in the promoter regions of the encoding genes of the co-expressive proteins induced by N-methyl-N ' - nitro-N - nitrosoguanidine ( MNNG ) .

方法：用断乳雄性Wistar大鼠，分为盐水对照组、N-甲基N-硝基-亚硝基胍（MNNG）和Selenite+MNNG组，用组织化学和图像分析方法观察大鼠肾上腺皮质的变化。

Methods : Weanling Wistar male rats were divided into saline control groups , N-methyl-N-nitro-N-nitrosoguanidine ( MNNG ) group , Se supplementation group before MNNG gavage . The changes of the adrenal cortex were studied by histochemistry and image analysis .

结果表明，对其中有的诱变剂虽有抑制效果但小于对AFB1的效果，对直接诱变剂甲基亚硝基胍几乎无抑制效果。

The results show that mixture No 1 and mixture No 2 possess inhibition effects but with a lower efficiency than that against AFB1 . These four drugs almost had no inhibitory effects on MNNG mutagenicity .

目的：研究低浓度N-甲基-N-硝基-N-甲基亚硝基胍对人羊膜FL细胞部分基因表达的影响，以助于阐明MNNG引起细胞应答反应的基因及其调控机制。

AIM : To study the gene expression changes of 95 genes in human FL cells after treatment with low concentration of N-methyl-N ' - nitro-N-nitrosoguanidine ( MNNG ) in order to elucidate the response genes and regulatory mechanism of human FL cells exposed to MNNG .

方法以甲基亚硝基胍（MNNG）为受试物诱导腭裂动物模型，采用抑制消减杂交技术从全基因组水平上对MNNG致腭裂相关差异表达基因进行筛选。

Method N-methyl-N ' - nitro-N-nitrosoguanidine ( MNNG ) was used as a known teratogen to induce cleft palate in ICR mice and a suppression subtractive hybridization ( SSH ) technique was applied to identify differentially expressed genes which related to cleft palate in ICR mice .

首先采用紫外线和亚硝基胍对乳酸菌进行单因素诱变，确定紫外线照射剂量为150s，并得到一株产酸力为57.85°T的菌株，比原菌株产酸力提高了3.05%；

UV and NTG were used to mutate HET-S. Firstly , HET-S was exposed in ultraviolet 150s , obtained a new strain . The acid-produced ability of the new strain could reach 57.85 ° T , increased 3.05 % than that of the original strain .

甲基硝基亚硝基胍诱发小鼠膀胱肿瘤早期病变的动态观察

Early pathological changes in bladder tumor of mice induced by n-methyl-n-nitro-n-nitrosoguanidine

对其进行紫外线诱变和亚硝基胍诱变复合处理，从血琼脂平板上筛选出一株不具有溶血性的突变菌。

A mutant without haemolysis was screened from blood agar plate .

亚硝基胍对苏芸金杆菌晶体和芽孢的影响

Effects of NTG on Crystals and Spores of Bacillus thuringiensis

尼美舒利对乙基硝基亚硝基胍诱导大鼠胃癌的化学预防作用

Effect of nimesulide on chemoprevention of N-ethyl-N-nitro-N-nitrosoguanidine-induced gastric cancer in rat model

喂饲酒精对大鼠肝抑制N-甲基-N′-硝基-N-亚硝基胍致突变性的影响

Effect of ethanol feeding on hepatic inactivation of N-methyl-N ′ - nitro-N-nitrosoguanidine mutagenicity

高盐饲料配合甲基硝基亚硝基胍诱发大鼠胃癌

Rat Gastric Carcinomas Induced by Administration of MNNG Associated with High Dose Sodium-Chloride Diet

微波-亚硝基胍复合诱变筛选纤维素酶高产菌株

Screening of high-yield cellulase mutant by microwave-NTG mutagenesis