二级亲属

方法采用家系遗传研究方法调查了90例强迫症先证者的一、二级亲属中精神疾病的患病率，并与100例健康者家系进行对照分析。

Methods The mental disorders in the first degree and second degree relatives of 90 probands with OCD were investigated and compared with those of 100 healthy families by the method of family genetic study .

乙型肝炎病毒感染导致的HCC具有非常明显的家族聚集性和遗传易感性，其发病率呈患者一级亲属、二级亲属递减，且均高于群体发病率。

Significantly , HCC which results from chronic B hepatitis virus ( HBV ) has familial aggregation and genetic susceptibility , and the incidence of HCC which are correlative with the first and the second degree relative decreased progressively , furthermore , the incidence were high than population risk respectively .

哮喘组一级、二级亲属有哮喘史83例，无哮喘史66例，II、ID、DD表达例数分别为16、23、44例和26、13、27例，有显著性差异。

The expression cases of II , ID , DD genotype were 16,23,44 in 83 asthmatic children with asthma history of primary , secondary relatives and 26,13 , 27 in 66 asthmatic children without asthma history , which was of significance between two groups .

一级、二级亲属的遗传度分别是0.670和0.466：通过复合分离分析不符合单基因显性、隐性、共显性遗传模式及环境模型和非主基因模式。

Mendelian , No-major-gene and Environment model was rejected by complex segregation analysis .

二级亲属包括伯姑舅姨、侄子女和祖父母。

Second-degree relatives are aunts and uncles , nephews and nieces , grandparents and grandchildren .

先证者一、二级亲属加权平均遗传度为（78±5）%，提示精神分裂症的发病以遗传因素为主，环境因素也起一定作用。

The weighted mean heritability was 78 ± 5 % , thus suggesting that the genetic factor play an important role in schizophrenia .

结果遗传模式研究结果发现一级亲属患病率＞二级亲属患病率＞三级亲属患病率＞群体患病率。

Results Study on genetic mode of SLE showed the order of prevalence rate was as follows : first-degree relatives > second-degree relatives > third-degree relatives > control relatives .

7358%有个人过敏史者，一级、二级亲属有哮喘史者分别为1698%和2075%。

73 58 % of patients with asthma had personal allergic history , one or two degree family history of asthma were 16 98 % and 20 75 % , respectively .

先证者一、二级亲属的OR值分别为6.21和2.51，遣传度（h~2）分别为48%和44%。

And , the heritability ( h ~ 2 ) of first degree relatives & second de - gree relatives of proband cases were appraised as 48 % and 44 % separately .

相关因素显示：19.22%有婴儿湿疹史，25.98%有过敏性鼻炎史，一、二级亲属有哮喘或过敏者占20%以上；

Determinants coexisting with asthma in children were history eczema ( 19.22 % ), history with allergic rhinitis ( 25.98 % ), and first or second level relatives with asthma or allergic disorder (﹥ 20 % ) .

另外，六种疾病患者的一、二、三级亲属的患病率和遗传度随亲属关系越远而逐渐降低。

In addition , the prevalence and heritability of these diseases in first - , second - and third-degree relatives of the proband gradually reduce .

方法对150例精神分裂症按一级亲属家族史阳性，二、三级亲属家族史阳性，家族史阴性分为三组，比较其血液流变学差异，并与70名健康人对照。

Methods : 150 cases with schizophrenia and 70 healthy subjects were studied for their hemorheological characters . For further comparison , the patients were stratified into three groups as first rank relative with , second rank relative with and without family history of psychosis .