中心体

中心体复制过程与细胞核内其他事件相耦合，并与DNA复制一样，以半保留方式复制。

Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events , including DNA synthesis .

中心体异常及P53蛋白过表达在食管癌变过程中的作用

Centrosome amplification and over-expression of P53 protein in esophageal carcinoma

抑癌基因p53对白血病K562细胞中心体异常的抑制作用及其机制

Inhibitory Effection and Mechanism of p53 Gene on Centrosome Abnormality in Leukemia Cell Line K562

中心体由一对中心粒（centrioles）和中心粒周围物质（Pericentriolarmaterial，PCM）组成。

Centrosome comprise a pair of centrioles and pericentriolar material ( PCM ) .

因此，我们认为p53的异常会通过RhoA/ROCK的过度活化损害四倍体细胞聚集多余中心体的能力，进而导致多极分裂的发生。

Thus , we conclude that p53 abnormality impaired centrosome clustering and lead to multipolar mitosis in tetraploid cells by modulating the RhoA / ROCK signaling pathway .

背景与目的：中心体（centrosome）是一个微小的细胞器。

BACKGROUND & AIM : Centrosome is a small cellular organelle .

中心体的主要功能是作为主要的微管组织中心（microtubuleorganizingcentres，MTOCs）。

The major function of centrosome is as the major microtubule-organizing centres ( MTOCs ) of animal cells .

异常中心体可产生多极纺锤体，使染色体错误分离及分配不平衡，介导染色体不稳定性（CIN）和非整倍体的形成。

Abnormal centrosome can cause multipolar spindle formation , chromosome mis-segregation , and unequal distribution , and finally leads to cancers .

癌基因BMI-1对中心体复制的调节作用

Role of Oncogene BMI-1 in Centrosomal Duplication

癌基因BMI-1在中心体复制扩增的调节中起着重要的作用。

These data strongly indicated that BMI-1 plays critical role in the regulation of centrosomal duplication .

计算了中心体上具有不同形状R环的5个算例，并根据计算结果讨论了R环改善排气管性能的科学机理，为R环的优化设计提供了一个参考。

The results of five examples with different R-shape annuluses around the central body of the pipe are presented and the reason why they improve pipes performance is discussed , and an useful programme for optimal design of the pipe is offered .

中心体定位的具有原癌基因属性的人源新基因cepo的功能研究

Functional Study of Novel Human Centrosomal Protein Oncogene-cepo

AuroraA从有丝分裂的前期到末期均定位在中心体上，对纺锤体的装配起着重要作用。

Aurora A is localized at the spindle poles from prophase to telophase and has emerged as a critical factor in the assembly of the mitotic spindle .

并以Hep-2细胞系为代表，应用免疫荧光方法检测喉癌中心体扩增情况；常规和高分辨G显带及荧光原位杂交（FISH）分析染色体不稳定状态。

Meanwhile Hep - 2 cell line was used as an example to detect centrosomal amplification by immunofluorescence and chromosomal instability by routine and high - resolution G - banding and fluorescent in situ hybridization ( FISH ) .

Nek家族对中心体的调节作用及其与肿瘤发生的关系

Regulation of Nek kinase family to centrosome and its correlation with tumorigenesis

我们结合转染技术及间接免疫荧光技术，观察细胞内DOC-1R转染基因表达对于DNA复制以及中心体复制的影响。

In the present study , the effect of DOC - 1R expression on DNA replication and centrosome duplication was investigated using plas-mid DNA transfection and dual immunofluorescent microscopy .

利用二体问题的中心体变质量的Jeans理论估计了太阳目前在主序阶段和将来后主序（红巨星）阶段由于上述两种机制造成的质量损失对地球轨道改变的长期效应。

The influences of solar mass-loss on the change rate of the semi-major axis and the orbital period of the earth could be happened while the Sun stays on the main-sequence and evolves as a red giant on the post-main sequence .

Nudel的256-291的这段氨基酸序列对于它定位到中心体上是必需的。AuroraA从有丝分裂的前期到末期均定位在中心体上，对纺锤体的装配起着重要作用。

The region containing residues 256-291 is essential for centrosomal localization . Aurora A is localized at the spindle poles from prophase to telophase and has emerged as a critical factor in the assembly of the mitotic spindle .

有丝分裂激酶Aurora-A具有调节中心体分离、成熟以及纺锤体装配的功能，并且在调节细胞周期G2/M期转变以及检测点（checkpoint）方面发挥重要的作用。

Aurora-A kinase plays an important role in centrosome separation , maturation and bipolar spindle assembly during mitotic phase . Aurora-A is also involved in the regulation of the G_2 / M transition and checkpoint .

CaMKⅡ作为Ca2+的下游信号分子，在受精后促进成熟促进因子（MPF）和细胞静止因子（CSF）的失活，并调节纺锤体微管的组装和中心体的复制过程。

As one of the down stream signaling molecules of calcium , CaMK ⅱ facilitates the inactivation of maturation promoting factor ( MPF ) and cytostatic factor ( CSF ) following fertilization , as well as the spindle microtubule organization and centrosome duplication .

HBXIP在肿瘤细胞的增殖、有丝分裂、中心体动态和细胞周期进展中发挥重要作用。

It was reported that HBXIP plays important roles in many cellular process , such as cell proliferation , apoptosis , mitosis , centrosome dynamics and cell cycle progression .

Hep-2细胞系有明显的中心体扩增：单个细胞中心体数目变化范围为1～7，有中心体扩增的细胞数为11%～23%。

Centrosomal amplification was apparent in Hep-2 cell line . The number of centrosome in a single cell changed from 1 to 7 , and Hep-2 cells with amplified centrosomes ( more than 2 in one cell ) were 11 % - 23 % .

最近的研究的发现，在果蝇和爪蟾系统中，AuroraA能够磷酸化TACC（Transformingacidiccoiledcoil）蛋白，并招募TACC蛋白到中心体上，与微管结合蛋白一起参与调控中心体微管的稳定性。

Recently , Xenopus and Drosophila transforming acidic coiled coil ( TACC ) proteins have been found to be the substrates of Aurora A. After phosphorylation by Aurora A , TACC proteins are recruited to centrosomes , and then contribute to modulating centrosomal microtubule stability with microtubule associated proteins .

这个家族在人类有Aurora-A，Aurora-B和Aurora-C三个成员，它们主要参与中心体的功能调节，双极纺锤体的形成以及染色体的分离过程。

The three members of this kinase family , identified so far , referred to as Aurora-A , Aurora-B and Aurora-C which are known to be involved in the regulation of centrosome function , bipolar spindle assembly and chromosome segregation processes .

~（60）CO-γ射线诱发的德国蜚蠊精母细胞中心体畸变

Centriole aberration in spermatocytes of the German cockroach induced by radiation

细胞分裂中中心体与染色体的仿真模型

A Simulation Model of Centrosome and Chromosome in Cell Division

在一些细胞中观察到界限清楚的中心体。

Clearly defined centrosomes have been observed in some cells .

中心体异常和食管癌发生相关性的实验研究

The Experimental Study on the Correlation between Centrosome Hypertrophy and Esophageal Carcinoma

含中心体喷嘴非淹没空化射流调制研究

Modulation Study on Unsubmerged Cavitating Jet from Nozzle with a Centre Cylinder

中心体异常相关基因的肿瘤学研究进展

Research Progress on Centrosome Abnormality Associated Genes in Oncology