下游序列

结论针对IGF-IR基因mRNA序列起始密码子及下游序列所设计的反义寡核苷酸能有效阻止mRNA的翻译功能，使其蛋白产物表达下调，达到封闭或减弱该基因表达的目的。

Conclusion Our data suggest that antisense ODNs complementary to the initiation codon of IGF-IR mRNA and its downstream sequence can effectively prevent the translation of the target mRNA into protein product , thus block or weaken the expression of IGF-IR .

丙型肝炎病毒被膜蛋白E1信号序列的切割受下游序列的影响

Effect of Downstream Sequence on the Cleavage of Envelop Protein 1 Signal Sequence in Hepatitis C Virus

为有效地分析水稻3′-UTR序列剪切位点上下游序列中的信息结构，提出了一个新的分析框架，即DNA序列的滑动窗口信息熵模型。

A new framework , named Information Entropy Model of Sliding Window ( IEMSW ), was proposed to effectively analyze the structural information contained in the 3 ' - UTR sequences around the polyadenylation site . 3 .

根据青枯菌Ⅱ型分泌系统中12个gsp基因的上下游序列，利用引物设计软件，设计出12对最佳gsp基因扩增引物。

According to upstream and downstream sequences of gsp genes , we designed 12 the best primers of gsp genes with the primer design softwares .

这种依赖于上下游序列的信号序列加工目前仅发现存在于IL12信号序列加工和黄病毒C/prM位点（prM信号序列）的加工。

To date , similar observations were only reported for the processing of IL 12 signal sequence and the C / prM site of flavivirus .

利用上游序列和下游序列的4-tuple与5-tuple的含量，其平均分类精度分别为94.68%和94.83%；

For the vector concatenation of upstream and downstream sequences , the average classification accuracies are 94.68 % and 94.83 % for 4-tuple and 5-tuple content respectively .

原核表达中优化起始密码下游序列的软件设计与实现

Design and Implementation of DB Sequence Optimization Software

同源重组载体pMADΔnos的构建是将PCR获得的nos基因上下游同源序列和壮观霉素抗性基因连入穿梭载体pMAD。

The homologous recombination vector pMAD Δ nos was constructed by the ligating the upstream and downstream sequences of nos acquired by PCR , and the spectinomycin resistance gene into shuttle vector pMAD .

用不同的SD序列LT-B基因的表达水平也有所不同，用基因本身SD序列可能要比用pBV220PL启动子下游的SD序列好；

The different SD sequences can affect the expression of LT-B gene a little .

根据α-珠蛋白基因起始密码子上游及终止密码子下游的保守序列设计引物，以牦牛基因组DNA为模板克隆并测定了α-珠蛋白基因序列。

The α - globin gene of yak was amplified and cloned by using the primers based on the conserved region of the upstream from the initiation codon and the downstream from the termination codon .

长江中下游降水变化序列与重建序列的吻合要较之于中国东部好，特别是1850年前。

The correlation of precipitation between simulated and reconstructed is better in the middle and lower Yangtze River Valley than in East China , especially before 1850 .

人类P53下游基因一致性序列研究

Study on human P53 downstream genes ' consensus sequences

方法首先将扩增的病毒prM基因导入pSfV的Sp6启动子下游并进行核苷酸序列测定。

Methods The amplified prM gene was cloned into the Sp6 promoter downstream of pSfV vector and its nucleotide sequence was determined .

Gli作为脊椎动物HH信号通路中的锌指核转录因子，与HH信号通路中下游基因的特定序列结合，直接调控HH信号通路目的基因的转录表达，在HH信号通路调控中起核心作用。

Gli , a zinc finger transcription factor in the vertebral HH signaling pathway , combines to the special sequences of distal HH targeted genes and directly controls the transcription of targeted genes , playing a key role in HH signaling pathway .

谱分析与交叉谱分析结果表明，长江中下游旱涝灾害等级序列在10～11年周期上与太阳黑子数存在相关，但两者有近1年的滞后性。

Both spectral and cross spectral analysis show that floods and droughts in the middle reaches of the Changjiang River is significantly relevant to sunspot activities with a chronological cycle of 10.2 years , 11 years and 11.5 years ;