核糖开关

在细菌中，SAM是受了SAM核糖开关绑定的，该开关与蛋氨酸或半胱氨酸合成的基因相关。

In bacteria , SAM is bound by the SAM riboswitch , which regulates genes involved in methionine or cysteine biosynthesis .

我们从理论上考察了突变的鸟嘌呤核糖开关GR（C74U）与氨基嘌呤、嘧啶和咪唑衍生物三种类似物之间的相互作用，以及氨基对结合方式和结合能力的影响。

The interactions of a mutant form of guanine riboswitch GR ( C74U ) with series of amino modified purines , pyrimidines and imidazole derivatives are investigated . How the number and positions of amino groups affect the binding modes and binding affinity is included .

博雷克在他的实验室里化学合成了核糖开关，让它们有效地调节基因表达，并预言这样的RNA结构存在于自然界。

Breaker had chemically created riboswitches in his own lab and-given their efficiency at regulating gene expressions-predicted such RNA structures would be found in nature .

本论文在对分子动力学模拟研究中力场参数和溶剂模型的选择做出比较评估的基础上，对一类具有多种调控功能的非编码RNA分子&核糖开关，进行了深入细致的模拟研究。

In this thesis , we first perform a series of tests and comparison of different force fields and solvation models for the simulation of RNA . After that , we investigate a class of non-coding RNA with various regulation functions & riboswitch through molecular dynamic simulations .

Riboswitch称为核糖开关，广泛存在于各种生物体内，可以认为是一类对小分子代谢物敏感的结构RNA，通过结合小分子代谢物在转录与翻译水平调控基因表达。

Riboswitches are called nucleic switches , which are widely founded in various organisms . They can be considered as a class of structure of RNA sensitive to small metabolites and can regulate genes expression at the level of transcription and translation by binding with the small metabolites .

核糖开关&一种基因表达调控元件

Riboswitch : a gene expression regulatory element

核糖开关可用于研究基因功能，开发新型药物及基因治疗。

Riboswitches can be used to gene function research , new drugs development and gene therapy .

找寻新核糖开关的范例，有了更多意外的发现。

When we started scanning bacterial genomes looking for new examples of riboswitches , we found still more surprises .

最近，波昂大学生命和医学科学中心研究人员在核糖开关的研究中又取得了重大突破。

A team at the interdisciplinary Life and Medical Sciences Center at the University of Bonn has now taken a meaningful step toward a better understanding of riboswitches .

对于氨基取代的嘧啶衍生物来说，氨基取代基的数目对其在结合口袋中的取向没有显著影响，但其位置的变化对核糖开关与配体的结合能力有严重影响。

For the pyrimidine derivatives bearing the amino groups , the number of amino groups had no significant influence on the orientations in the binding pocket , while the position changes affected the binding affinity seriously .