突变型基因
- 名mutant gene
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采用这个改良的方法,分析了拟南芥野生型和ast突变型基因表达的差异。
Based on the improved procedure , the differential gene expression were studied between immature siliques of Arabidopsis wide type and ast mutant .
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SHP-2野生型基因可促进乳腺癌转移而其突变型基因可抑制转移
The wild-type SHP-2 gene promotes but the mutated SHP-2 gene inhibits the metastasis of breast cancer
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突变型p53基因产物的表达也与胃癌肝转移密切相关(P<0.01);
Expression of mutant p53 gene product was also related to metastasis of stomach cancer to liver ;
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采用一步法RT-PCR检测突变型p53基因mRNA水平的表达。
The mRNA expression of mutant p53 gene was detected by one-step RT-PCR .
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下调突变型P53基因蛋白的表达;
Regulating the expression of mutation P53 gene down ;
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突变型p53基因在人膀胱肿瘤中的表达及临床意义
Abnormal expression and clinical significance of muta-tion p53 gene on human bladder cancer
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HP感染可促进突变型p53基因表达增强。
It was supposed that HP infection caused mutated p53 gene expression to increase .
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目的:探讨突变型p53基因产物在胃癌中异常表达的意义。
Objective : To investigate the significance of abnormal expression of p53 in gastric carcinoma .
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胃癌细胞DNA倍体和突变型p53基因产物表达与转移扩散的关系
A Study on DNA Ploidy , Mutant p53 Gene Product Expression and the Relationship with Metastasis in Stomach Cancer
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胃癌中VEGF及突变型p53基因表达及临床意义研究
Expressions of VEGF and mutant p53 gene and their clinical significance in patients with gastric carcinoma
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研究表明突变型p53基因(mt-p53)可上调血管内皮生长因子(VEGF)的表达,促进血管生成。
The wide type p53 gene promotes vessel formations by up-regulating vascular endothelial growth factor ( VEGF ) .
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鼠双微粒体-2基因和突变型p53基因表达与肝癌细胞增殖和凋亡关系的研究
Expression of Murine Double Minute-2 Gene and Mutant p53 and Their Relation with Cell Proliferation and Apoptosis in Hepatocellular Carcinoma
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突变型P53基因在正常胃黏膜,浅表性胃炎和萎缩性胃炎中不表达,在重度异型增生与胃癌组织间无显著差异(p>0.05)。
No significant difference was observed for p53 expression level between severe dysplasia and carcinoma ( p > 0.05 ) .
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方法通过向肺癌细胞中分别转染携带有荧光蛋白基因的野生型P53基因和突变型P53基因,而后用荧光显微镜观察荧光蛋白表达;
Methods Through transfection to lung cancer cells p53 gene with fluorescent protein gene , and observation of expressed products by fluorescent microscopy .
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提示Bcl-2及突变型p53基因产物与甲状腺肿瘤的发生、发展及预后有关。
The results indicate that the expression of Bcl-2 and mutant-type p53 in thyroid tumor is associated with tumor genesis , growth and prognosis .
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目的探讨突变型P53基因在人乳腺癌组织中的表达规律及其与淋巴结转移等之间的关系。
To research expression of the mutated p53 gene in human breast cancers and its correlation with lymph node metastasis and other prognostic factors .
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结论:灵芪胶囊对H(22)荷瘤小鼠有明显抑瘤作用,其机制可能与抑制突变型p53基因和bcl-2基因表达有关。
Conclusion : Lingqi-capsule can obviously inhibit mice sarcoma H_ ( 22 ) . The mechanism of action is correlation of p53 and bcl-2 gene expression decrease .
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突变型Axin基因在神经胶质瘤细胞系C6中的功能研究
Functions of mutant Axin gene in C6 glioma cell line
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初步证据显示,在转基因青蒿植株中,突变型SS基因已取代野生型SS基因。
The preliminary data showed that the wild-type SS gene was replaced by mutated SS gene in the transgenic A. annua plant .
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突变型p53基因的编码蛋白不但丧失上述功能,甚至出现了促使细胞癌变的作用。
The protein ( P53 ) encoded by mutant p53 gene ( mtp53 ) not only losses these functions , but also make cell malignant transformation .
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目的:探讨大肠腺癌突变型p53基因蛋白表达与p53基因cDNA突变间的相互关系和意义。
Purpose To analyse the significance and relationship between the expression of mutant type p53 gene protein and p53 gene cDNA mutation in the colorectal adenocarcinomas .
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上述结果提示:胃癌细胞的DNA非整体倍体和突变型p53基因产物的表达在其血行转移过程中起重要作用,但作用机理可能有所不同。
The results suggest that both DNA aneuploid and the expression of mutant p53 gene product play important role in blood metastasis , the machanism may not be the same .
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目的分析燃煤型砷中毒患者皮肤癌变过程中增殖细胞核抗原(PCNA)、B-淋巴细胞瘤/白血病-2抗凋亡蛋白(BCL-2)和突变型P53基因蛋白(P53mt)的表达情况及相关性。
Objective To analyze cooperative expressions of PCNA , BCL 2 and P53 mt proteins in patients ' skin with arseniasis due to coal burning .
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结论PD可有效降低肺动脉压,延缓大鼠CHPH进程,其机理可能与抑制突变型p53基因表达及细胞增殖,从而有效抑制肺血管重建有关。
It may be related to the inhibition of p53 which can enhance proliferation and decrease apoptosis , that contribute to postpone the development of pulmonary vascular remodeling .
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转染突变型NPM基因,观察其对白血病细胞增殖和凋亡的影响。
To observe the effect of mutated NPM on proliferation and apoptosis of KG-1a cells .
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以上结果表明:突变型p53基因在CNE-2Z细胞中有较高表达;通过抑制细胞PKC活性和耗竭PKC含量后,均可降低p53基因的表达;
These results indicated that mutate p53 gene in CNE 2Z cells showed a high expression and it reduced markedly by inhibiting the PKC activity or reducing the PKC content .
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首先在通过脂质体介导下将突变型NPM基因转染入KG-1a细胞并筛选稳定表达株。
Firstly , NPM mutant gene was transfected into KG-1a using Lipofectamine 2000 .
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突变型flk-1基因转染抑制肝癌在裸鼠体内血管形成、生长和转移
Gene Transfer of Dominant-Negative flk-1 Mutant Inhibits Angiogenesis , Growth and Metastases of Human Hepatocellular Carcinoma in Nude Mice
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主要的结果和结论如下:1.检测KG-1a细胞中CD34抗原和突变型NPM基因的表达。
Main results and conclusions as follow : 1 . CD34 molecule and expression of NPM mutant gene in KG-1a cells was detected .
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结果转染突变型Axin基因与转染野生型Axin基因的C6细胞在生长速度,克隆形成能力方面均显著降低,且组间无差别;
Results In comparison with the cells transfected with empty vector , the growing speed and colony formation ability of the cells transfected with wild Axin gene and mutant Axin gene were decreased significantly ;