死亡受体

外源性途径开始于一个死亡受体，如Fas等。

The extrinsic pathway begins with a death receptor , such as Fas .

TRAIL及其死亡受体在宫颈癌组织中的表达和临床意义

Expressions of TRAIL and its death receptor in tissue of cervical carcinoma and its clinical significance

目前研究发现细胞凋亡信号的传导主要通过两条信号途径来完成，其一为细胞色素C线粒体途径，其二为死亡受体途径。

Two death signal pathways have been identified to control the apoptosis of cell , the mitochondria C pathway and the death receptor pathway .

宫颈癌细胞TRAIL死亡受体和诱骗受体表达的研究

Expressions of death receptors and decoy receptors of TRAIL in cervical carcinoma cells

CBL调节死亡受体在脂筏内重新分布参与奥沙利铂增强TRAIL诱导胃癌细胞凋亡

Oxaliplatin Enhances TRAIL-induced Apoptosis in Gastric Cancer Cells by CBL-regulated Death Receptor Redistribution in Lipid Rafts

肿瘤细胞膜TNF受体收到配体的信号后，通过死亡受体途径使肿瘤细胞发生凋亡；（2）对肿瘤细胞的直接细胞毒性。

TNF receptor on tumor cellular membrane received ligand sign , made tumor cell apoptosis with death receptor pathway ; ( 2 ) cytotoxicity directly to tumor cell .

凋亡有三条途径：死亡受体途径、线粒体途径和CTL介导的颗粒酶途径。

There are three pathways to apoptosis : death receptor pathway , the mitochondrial pathway and the CTL-mediated granzyme pathway .

TRAIL死亡受体和诱骗受体在肿瘤细胞系中的表达具有差异性，这种差异性可在一定程度上解释不同细胞对TRAIL诱导凋亡的敏感度。

The expression level of TRAIL receptors on carcinoma cell lines are various , which may explain the difference in their sensitivity to TRAIL to a certain extent .

Fas是细胞表面重要的死亡受体，细胞在接收到经Fas传递的凋亡信号后，可以经过两种条途径引发细胞程序性死亡。

Fas is an important death receptor on cell surface , and apoptosis signals received by Fas can through the two signaling pathways triggered programmed cell death .

在这一复杂的机制中，作为死亡受体与配体的Fas/Fas以及作为死亡蛋白酶的Caspase-3可能起重要作用。

In this complicated mechanism , Fas / FasL which acts as death receptor - ligands and caspase - 3 as death proteinase maybe important .

在1型糖尿病中，胰岛β细胞主要通过死亡受体介导的信号转导途径及颗粒酶B途径发生凋亡，而在2型糖尿病中，线粒体途径是胰岛β细胞凋亡的主要信号转导途径。

In type 1 diabetes , signal transduction pathway mediated by death receptor and granzyme B pathway participate in the beta-cell apoptosis , however , the main transduction pathway leading to beta-cell apoptosis in type 2 diabetes is mitochondria pathway .

抑制JNK-c-jun及FasL的表达，从而抑制死亡受体途径的凋亡。

Inhibiting death receptor pathway apoptosis by suppressing JNK-c-jun mediated expression of FasL .

ERs途径是独立于死亡受体途径和线粒体途径的第3条凋亡信号途径。

ERs pathway is the third apoptosis signaling pathways independent of the mitochondrial pathway and the death receptor pathway .

但目前越来越多的研究表明TRAIL参与RA的发病过程：TRAIL与其死亡受体结合后可诱导RA患者关节内破骨细胞的凋亡。

But more and more research indicated that TRAIL impact on the pathogenesis of RA . TRAIL can interact with five different receptors , inducing apoptosis of osteoclasts in RA patients .

芹菜素能够抑制细胞内组成性和外源性细胞因子（如IL-6、IGF-1等）激活的生存信号通路；并活化死亡受体介导的Caspase-8/Caspase-3凋亡信号通路，最终诱导细胞发生细胞凋亡。

Apigenin inactivated the intracellular and the extracellular cytokines-induced survival signaling pathways , and resulted in the activation of caspase-8 / caspase-3 apoptosis pathways , finally induced cell apoptosis .

TRAIL（肿瘤坏死因子相关的凋亡诱导配体）属于肿瘤坏死因子超家族，在与死亡受体结合后，可启动凋亡信号的转导。

TRAIL ( tumor necrosis factor-related apoptosis-inducing ligand ) is a member of the tumor necrosis factor family . After binding with its death receptors , the apoptosis signaling pathway is activated .

普通死亡受体4（DR4）的基因多态性不能诱发卵巢癌

Common death receptor 4 ( DR4 ) polymorphisms do not predispose to ovarian cancer

结论姜黄素可能通过线粒体途径与死亡受体途径诱导鼻咽癌NCE细胞凋亡。

Conclusions Curcumin induced apoptosis of NCE cells both through mitochondria-dependent pathway and death receptor pathway .

免疫组化和流式细胞术检测肾脏TRAIL基因及其死亡受体DR4、DR5的蛋白表达。

Immunohistochemistry and FCM were used to detect the expression of TRAIL and its death receptors ( DR4 and DR5 ) .

而在外源性通路中，当死亡受体与相应的配体结合后激活caspase-8。

While in the extrinsic pathway , the combination of ligands to the corresponding death receptors on the membrane activates caspase-8 .

5FU可能既通过死亡受体信号传递途径，又通过线粒体途径诱导肿瘤细胞凋亡。

5-FU induces tumor cell apoptosis possibly through both the death receptor signaling pathway and the mitochondrium-mediated pathway .

结论：苦参碱能诱导C6胶质瘤细胞的凋亡，其机制与死亡受体途径和线粒体途径的众多基因有关。

Conclusion : Matrine can induce C6 glioma cell apoptosis and the mechanism might be related to a number of genes involved in death receptor pathway and mitochondrial pathway .

目的利用抗DR5单克隆抗体（mAb），检测死亡受体5（DeathRecepter5）在肿瘤细胞系表面的表达。

Objective : To establish hybridomas that produce anti-death receptor 5 mAbs and check surface expression of death receptor on cell lines .

结论死亡受体DR5在诱导肝癌细胞凋亡中起重要的作用；

Conclusion Death receptor 5 as a target plays an important role in the course of HCC apoptosis induction .

TRAIL诱导的凋亡与炎症细胞浸润程度相关，但决定于死亡受体的表达水平，配体受体二者缺一不可。

TRAIL induced apoptosis was positive correlation with the extent of inflammatory cells infiltration , but determined by the level of death receptors expression , ligand and receptor not a single one can be omitted . 5 .

目的：探讨宫颈癌组织中TRAIL及其死亡受体DR4的表达与宫颈病变之间的关系。

Objective : To investigate the relation between the expression of TNF-related apoptosis inducing ligand ( TRAIL ) and its death receptor ( DR4 ) and cervical lesion .

新近日益增多的研究结果表明NHL常表现为对死亡受体介导的凋亡途径的抵抗。逃避凋亡机制有多种，其中包括该途径相关基因的失活突变。

There are accumulating evidences that NHL cells are often resistant to the death receptor-mediated apoptosis by several mechanisms , including inactivating mutations of the genes involved in this pathway .

前列腺癌组织中死亡受体DR4、DR5为80%（16/20）；

The positive expression of DR4 、 DR5 in human prostate cancer were both 80 % ( 16 / 20 );

除二型TNF对瘤细胞的胞毒效应外，TM-TNFm可诱导肿瘤细胞表达死亡受体Fas，而S-TNFm则可明显促进肿瘤灶局部淋巴细胞的浸润（P<001）。

Besides the cytotoxicity of the both forms of TNF , TM-TNF was found to induce the expression of death receptor Fas by tumor cells and S-TNF was shown to promote frank lymphocyte infiltration in the site of tumor .

而细胞表面的死亡受体CD95在细胞凋亡中起着重要作用。

One of the reasons for CD4 + T cell apoptosis is the death receptor CD95 , which plays an important role in apoptosis .