多形性胶质母细胞瘤

多形性胶质母细胞瘤（GBM）显示肿瘤细胞深染和多形性

This glioblastoma multiforme ( GBM ) demonstrates marked cellularity with marked hyperchromatism and pleomorphism .

多形性胶质母细胞瘤的影像学诊断

Imaging Diagnosis of Glioblastoma Multiforme

人类多形性胶质母细胞瘤中变异型IκBα基因抑制血管新生的研究

Mutant-type I κ B α gene inhibits angiogenesis in human glioblastoma multiform cells

X射线诱导多形性胶质母细胞瘤细胞系的凋亡

Apoptosis induced by X-ray in glioblastoma multiform cell lines

结果：多形性胶质母细胞瘤CT表现为低密度影，瘤内卒中表现为高密度；

Results : CT appearance of glioblastoma multiforme was low density image , intratumorally apoplexy was high density image .

变异型IκBα抑制人类多形性胶质母细胞瘤细胞中血管生长因子VEGF及IL-8的表达

Mutant-type I κ B α inhibit the expression of VEGF and IL-8 in human glioblastoma multiform cells

~（60）Coγ射线对多形性胶质母细胞瘤中的肿瘤干细胞的影响

Sensitivity of Brain Tumor Stem Cells from Multiform Glioblastomas to ~ ( 60 ) Co γ - ray in Vitro

磷酸化JNK与磷酸化c-Jun在多形性胶质母细胞瘤中的表达及意义

Clinical significance of p-c-Jun N-terminal kinase and p-c-Jun expression in glioblastoma

方法：经手术病理证实的多形性胶质母细胞瘤21例，其中20例行CT扫描，18例行MRI检查，分别分析其影像学表现。

Methods : 21 cases of glioblastoma multiforme were proved by surgical and pathologic findings.20 of them were performed by CT , 18 performed by MRI , analysing the imaging manifestations of them .

结论IκBαM基因可有效抑制胶质瘤中的血管新生从而抑制肿瘤的生长，这可作为人类多形性胶质母细胞瘤抗血管治疗的理论基础。

Conclusion I κ B α M gene transfer could inhibit in vivo angiogenesis , therefore , suppress tumorigenicity of human glioma cells . This could be a theoretical basis in the anti-vascular therapy of human glioma .

目的研究变异型IκBα（IκBαM）基因在人类多形性胶质母细胞瘤（GBM）中对血管新生的抑制作用。

Objective To investigate the inhibitory effects of mutant-type I κ B α( I κ B α M ) gene on angiogenesis in human glioblastoma multiform ( GBM ) cells .

多形性胶质母细胞瘤（GBM）是最常见的致命性的脑部肿瘤。

Glioblastoma multiforme ( GBM ) is the most common and lethal type of brain cancer .

目的研究原发性多形性胶质母细胞瘤7号染色体等位基因失平衡（allelicimbalance，AI）发生率，寻找与胶质母细胞瘤发生、发展可能相关的染色体区域。

Objective Allelic imbalance ( AI ) on chromosome 7 in primary glioblastoma multiforme ( GBM ) was detected to locate the chromosomal regions probably associated with the pathogenesis of GBM .

目的探讨磷酸化JNK（p-JNK）与磷酸化c-Jun（p-c-Jun）在多形性胶质母细胞瘤（GBM）中的表达及意义。

Objective To explore the clinical significance and the expression of phosphorylated c-Jun N-terminal kinase ( p-JNK ) and phosphorylated c-Jun ( p-c-Jun ) in glioblastoma ( GBM ) .

目的评价染色体14q的（杂合性）丢失是否与原发性多形性胶质母细胞瘤的发生发展有关，并确定14q上可能存在的共同杂合性丢失区域。

Objective To evaluate whether deletion of chromosome 14q is involved in the carcinogenesis of primary glioblastoma multiforme and to identify possibly common deletion regions .

多形性胶质母细胞瘤（GBM）是一类具有高侵袭特点的原发性脑肿瘤，肿瘤组织常常入侵周围正常组织，外科手段治疗效果不理想，术后常复发，患者预后差。

Glioblastoma multiform ( GBM ) is a highly malignant , lethal primary brain tumor . The therapeutic efficacy of surgery is not ideal because it infiltrates the surrounding normal tissue , thus GBMs have also associated with poor prognosis and short life expectance .

并且，高级别胶质瘤（间变型星形细胞瘤WHOm；多形性胶质母细胞瘤WHOW）患者的预后情况依然不佳。因此，临床上期待有更加行之有效的治疗方式。

The prognosis for patients with high-grade gliomas , which include anaplastic astrocytoma ( WHO ⅲ) and glioblastoma multiforme ( GBM , WHO IV ), remains dismal . Hence , there is a great hope for novel therapeutic approaches .

原发性多形性胶质母细胞瘤7号染色体等位基因失平衡状况的研究

Study on allelic imbalance of chromosome 7 in primary glioblastoma multiforme

多形性胶质母细胞瘤可见片状坏死或大量厚壁血管增生。

Glioblastoma multiforme had sheet necrosis and large think wall blood vessels .

肿瘤的性质以星形细胞瘤为最常见，其次为多形性胶质母细胞瘤，室管膜瘤占第三位。

The nature of gloom is firstly astrocytoma , secondly glioblastoma , thirdly ependymoma .

脑多形性胶质母细胞瘤水肿带大小与预后相关性的分析

The Potential Correlation between the Size of Peripheral Edema and Prognosis of Glioblastoma Multiforme

斑片状浓染型以多形性胶质母细胞瘤为主，微血管密度为77.69±18.28，生存期14.9个月。

Most patch-like pigmented tumors were glioblastoma multiforme with microvessel density of 77.69 ± 18.28 and mean survival time of 14.9 months .

即使是近年来神经科学的发展，胶质瘤尤其是多形性胶质母细胞瘤目前的所有治疗方法均无有效治愈方法。

Despite of the progress of neuroscience , gliomas , glioblastoma ( GBM ) tumors in particular , are refractory to all current therapeutic approaches .

结果间变性星形细胞瘤7例，多形性胶质母细胞瘤3例，少突胶质瘤1例，低级别胶质瘤1例。

Results There were 7 cases with anaplastic astrocytoma , 3 cases with glioblastoma multiforme , 1 cases with oligodendroglioma , 1 cases with lower grade glioma .

目的研究术后不同辅助治疗手段对多形性胶质母细胞瘤患者生存期的影响，不同因素对预后的影响。

Objective To define the role of different adjuvant treatment strategies after operation of glioblastoma multiform ( GBM ) patients and to investigate the value of different prognostic factors .

多形性胶质母细胞瘤是成人常见的颅内原发性肿瘤，呈高度恶性，治疗困难，预后差。

Glioblastoma Multiforme is one of the most common primary tumors in the central nervous system in adult that is highly malignant and difficult to treat , whose prognosis is poor .

单发者71例，多发者3例，1例颞叶多形性胶质母细胞瘤合并多发性血管网状细胞的混合瘤。

The tumor was solitary in 71 cases , and multiple is 3 , and the mixed tumor of glioblastoma multiforme and multiple angioreticuloma was located in the temporal lobe in 1 patient , which was rare .

低分级（星形细胞瘤+间变性星形细胞瘤）1年生存率55%，高分级（胶质母细胞瘤+多形性胶质母细胞瘤）1年生存率8%。

The one-year survival rate of patients with low grade glioma ( astrocytoma + anaplasia astocytoma ) was 55 % , while that of patients with high grade glioma ( colloid blastoma + polytypic colloid blastoma ) was 8 % .

结果1CD44s在脑膜瘤、多形性胶质母细胞瘤和脑转移瘤中的表达率分别为15%，100%和90%，其表达在前两者间有显著性差异（P<0.01）；

RESULTS CD44s was expressed in 15 % of meningiomas , 100 % of GMs and 90 % of brain metastases , and there was a significant difference between the expression of CD44s in meningiomas and that in GMs ( P < 0 01 ) .