多肽药物

含氟氨基酸及其衍生物在多肽药物中的应用

Application of fluorinated amino acids and their derivatives in polypeptide drugs

介绍多肽药物的生物活性分析、结构分析、纯度分析的发展状况。

The progress of the analysis of polypeptide drugs was reviewed , putting emphasis on bioactivity analysis , structure analysis and purity analysis .

若用二倍最小抑菌浓度（2×MIC）时活菌数则显著减少到原来的1/10000.结论：①PEI的抗真菌活性与文献报道的其他阳离子型多肽药物效果相当。

A remarkable ( 10 000 - ) fold of reduction was observed at PEI concentration of 2 × MIC . CONCLUSION : The anti-fungal activity of PEI is comparable to other cationic peptides reported in literatures .

多肽药物促进伤口愈合动物实验

The Animal Experiment of Promoting Wound Repair with Peptide

蛋白质和多肽药物质量控制中分析方法的应用概况

The Application of Analysis Method of Protein and Polypeptide Drug in Quality Control

重组蛋白多肽药物生物等效性研究的必要性、可行性和方法学

The significance , feasibility and methodology of bioequivalence studies on recombinant protein or peptide

重组蛋白多肽药物的临床药代动力学

Clinical pharmacokinetics of recombinant protein or peptides

蛋白和多肽药物的透粘膜吸收

Transmucosal Absorption of Protein and Peptide Drugs

开发抗癌的基因及多肽药物是本世纪的重任。

The exploration of antitumor gene drugs is the most important task in the 21st century .

选择的酶体系可用于评价多肽药物的体外代谢性质。

The selected enzymatic systems can be successfully used to evaluate in vitro metabolisms of peptide drugs .

近年来，多肽药物化学形成并迅速发展成为药物化学的重要分支。

In recent years , the peptide chemistry begins to form and become an important branch of pharmaceutical chemistry .

转铁蛋白作为一种药物载体，在蛋白多肽药物的口服给药领域有着美好前景。

The utilization of transferrin as a carrier in peptide and protein peroral drug delivery is a promising approach .

通常情况下，蛋白质和多肽药物被贮存在低温条件，甚至十被冻干成为固体形态，以期获得理想的效期。

They usually have to be stored under cold conditions or even freeze-dried to a solid form to achieve an acceptable shelf life .

综述了几种多肽药物常用的长效改造方法如化学修饰、基因融合、点突变以及药物制剂释放系统的改造。

To reach this goal , the following ways such as chemical modification , gene fusion , point mutation and delivery systems revolution are reviewed .

它是蛋白质和多肽药物一般采用注射给药的原因，而不是象绝大多数化学小分子药物那样通过口服给药。

Instability is one of the major reasons why protein and peptide pharmaceuticals are administered traditionally through injection rather than taken orally like most small chemical drugs .

结果与结论该方法特异性、线性及线性范围、灵敏度、重现性、回收率均可达到蛋白多肽药物药代动力学研究的要求。

Results and Conclusion The specificity , linear range , reproducibility and recovery for the method could meet the requirements for studying pharmacokinetics of bioactive proteins or peptides .

本文概述了近年来转铁蛋白在蛋白多肽药物口服给药中的作用及有关转运机制的研究进展。

In this paper , the progress of transferrin applied in protein and peptide peroral delivery is reviewed , and the transportation mechanism of transferrin is also discussed .

目的应用噬菌体环肽库筛选肿瘤坏死因子α（TNF-α）的模拟肽，为研制模拟TNF-α的新型多肽药物奠定基础。

Objective To develop a new type of tumor necrosis factor - α ( TNF - α) peptide as drug , TNF - α mimic peptides were selected from disulfide constrained phage peptide library .

蛋白质和多肽药物研究进展迅速，蛋白质和多肽药物的分析方法和相关检测设备也在不断地更新和改进，从而为该类药物的开发研究、质量控制和临床应用都提供了重要的手段。

Studies of protein and polypeptide drugs are rapidly developed , their analysis method and their corresponding detected equipment are also ceaselessly renovated and improved . All these concerned have provided important means for drug exploitation , quality control and appliance in clinic of protein and polypeptide drugs .

应用抗CD分子单抗作多肽类药物的生物活性检测

Biological Active Test of Polypeptide Medicine By Anti-CD Molecules Monoclonal Antibody

神经生长因子（Nervegrowthfactor，NGF）属于典型的大分子多肽类药物，本论文试图通过对NGF的研究来考察大分子多肽类药物的脑靶向传递系统。

Nerve growth factor ( NGF ) belongs to the kind of classic molecular peptide which is produced by nerve and target cell managed by nerve .

神经生长因子（Nervegrowthfactor，NGF）属于大分子多肽类药物，能影响促进中枢和外周神经元分化、生长和存活，用于治疗神经系统疾病。

Nerve growth factor ( NGF ) is a kind of very important peptide to the human body . It can strongly affect cell division and growth and it can cure nerve system disease .

同传统的基因工程多肽类药物相比，小分子药物具有易被吸收，没有免疫原性和高亲和力等优势，本实验利用SELEX技术寻获能与TNF结合的寡核苷酸适配子。

Compared with traditional recombinant protein drugs , small molecular drugs have any advantages , such as easy absorbance , no immunity and high affinity etc.

结论：LCESIMS/MS联用法为基因重组多肽类药物的一级结构分析和质量控制提供了新途径。

Conclusion : This paper revealed that LC-ESI-MS / MS had provided a new technique in primary structure analysis and quality control of DNA-derived recombinant peptide pharmaceuticals .

多肽类药物的口服吸收及其剂型研究

The Study of Oral Absorption and Delivery Systems for Peptide Drugs

蛋白多肽类药物制剂学研究进展

Advances in Research on Pharmaceutics of Protein and Peptide Drugs

多肽类药物制剂研究现状

Current Status of Study on the Preparations of Polypeptide Drug

蛋白质多肽类药物非注射制剂研究现状

Current research status on the non-parenteral preparations of protein and peptide drugs

胶体给药在蛋白质多肽类药物中的应用

The application of colloidal drug delivery systems in protein and peptide drugs

综述了蛋白多肽类药物药代动力学机制研究的某些进展。

The pharmacokinetic research of protein polypeptides was reviewed in this paper .