叔丁氧羰基
- 网络BOC;t-BOC;N-Boc
叔丁氧羰基-
利用叔丁氧羰基酸酐（（Boc）2O）对Tris上的氨基进行保护，对mPEG端羟基依次进行羧基化、酰氯化等活化处理，通过酰氯与羟基的官能团反应合成出目标分子。
The first step was to protect the amino group of Tris by using t-butyloxycarbonyl anhydride (( Boc ) 2O ), then mPEG was activated by changing hydroxide terminal into acid chloride and carboxylation of mPEG was fulfilled before .
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目的：探讨非天然氨基酸N-叔丁氧羰基化反应的适宜溶剂系统。
Objective : To study the solvent systems suitable for N-tert-butoxycarbonylation of non-natural amino acids .
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结论：水-四氢呋喃溶剂系统较适用于脂溶性大的非天然氨基酸N-叔丁氧羰基化，收率高，后处理简单。
Conclusion : Water-THF system is suitable for N-tert-butoxycarbonylation of lipophilic non-natural amino acids , with high yield and simple post-treatment .