阿司咪唑

雷尼替丁与阿司咪唑联合治疗慢性荨麻疹临床观察

Clinical Observation on Chronic Urticaria Treated with Ranitidine and Astemizole

结论：阿司咪唑是一种治疗轻、中度哮喘的安全有效的药物。

CONCLUSION : Astemizole is a safe and effective drug for mild to moderate bronchial asthma .

4-氨基吡啶（4-AP）1mg·kg~（-1）颈背部sc能诱发小鼠舔体反应，该反应可被苯海拉明、氯苯那敏或阿司咪唑所抑制。

4-Aminopyridine ( 4-AP ) 1 mg · kg-1 sc at the scruff induced a licking response in mice .

治疗组与对照组分别口服西替利嗪和阿司咪唑各10mg／d×10d，并辅以0.5%可的松和1%麻黄碱滴鼻，每日2～3次。

Both groups were received nasal administrations with 0.5 % cortisone and 1 % ephedrine , bid or tid , for 10 d.

阿司咪唑治疗支气管哮喘

Astemizole in treating bronchial asthma

方法用不同剂量的阿司咪唑对小鼠灌胃，分别记录不同时间的心电图变化。

METHOD Recording the ECG of mice in different time after they were admistrated with astemizole in different dose in different time .

结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。

CONCLUSION : The effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole .

目的通过观察小鼠心电图的变化，研究阿司咪唑对心脏的急性毒性，了解其致心律失常的类型，推测其致心律失常的机制。

OBJECTIVE To study the acute toxicity on heart and the arrhythmia types caused by astemizole via studying the change of electrocardiogram ( ECG ) in mice .