丙戊酸

用非线性混合效应模型（NONMEM）考察固定效应对丙戊酸相对清除率的影响。

The influence of the fixed effects on relative clearance of VPA was investigated using Nonlinear Mixed Effect Model ( NONMEM ) .

丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响

The Inhibitory Effects of VPA on Angiogenesis of Human Ovarian Cancer in Nude Mice

气相色谱测定CSF、脑组织中丙戊酸浓度

Determination of Valproate in CSF and brain tissue with Gas Chromatography

该研究小组在某些天然食物原料中发现了被他们称之为在化学上同丙戊酸（valproicacid）惊人相似的成分，而丙戊酸是在医学上被广泛应用于情绪稳定的处方药物。

The team found natural ingredients bearing what they describe as ' a striking chemical similarity ' to valproic acid , a widely used prescription mood-stabilizing drug .

该研究小组在某些天然食物原料中发现了被他们称之为“在化学上同丙戊酸（valproicacid）惊人相似”的成分，而丙戊酸是在医学上被广泛应用于情绪稳定的处方药物。

The team found natural ingredients bearing what they describe as ' a striking chemical similarity " to valproic acid , a widely used prescription mood-stabilizing drug .

目的：探讨丙戊酸（valproicacid，VPA）对人卵巢癌细胞株SKOV3细胞上皮性钙粘附素（E-cadherin）表达的影响。

Objective : To investigate the role of valproic acid on the expression of E-cadherin in ovarian cancer cell line SKOV_3 cells in vitro .

丙戊酸诱导白血病U937细胞凋亡机理的实验研究

Empirical Study on the Mechanism of the Apoptosis Induced by VPA

目的：观察丙戊酸（valproate，VPA）对戊四氮（pentylenetetrazol，PTZ）点燃的自由活动大鼠海马胞外兴奋性氨基酸类神经递质动态释放过程的影响。

Aim : To study the dynamic release of amino acid transmitters induced by valproate in pentylenetetrazol-kindled freely moving rats ' hippocampus .

丙戊酸（valproicacid，VPA）作为一种组蛋白去乙酰化酶抑制剂，能特异性抑制组蛋白去乙酰化酶的活性，提高细胞内组蛋白乙酰化水平，激活基因的表达。

Valproic Acid ( VPA ), a histone deacetylase inhibitor , could specifically inhibit the histone deacetylase activity , increase histone acetylation , and active gene expression in somatic cells .

报道1例丙戊酸（VPA）诱发婴儿肝衰竭病例。

A case of valproic acid ( VPA ) - induced hepatic failure was reported . An 8.5-month-old female developed infantile spasm at 1 month of life .

目的研究丙戊酸（VPA）对人卵巢癌A2780细胞生长及血管生成和转移相关因子（VEGF、MMP-9、MMP-2、E-cadherin）表达的影响。

Objectives To investigate the effects of Valproic acid ( VPA ) on the proliferation of human ovarian carcinoma cell line A2780 and the expression of angiogenesis and metastasis related factors ( VEGF 、 MMP-9 、 MMP-2 and E-cadherin ) .

目的探讨丙戊酸（VPA）在不同年龄、以及与酶诱导剂联合用药时肝脏毒副作用差异及其机制。

Aim To explore the differences of pathogenesis for the hepatotoxicity induced by chronic treatment of valproic acid ( VPA ) in different ages , and in combination administration with inducers of liver enzyme .

丙戊酸盐和卡马西平诱发的药疹伴嗜酸性粒细胞增多及系统症状：抗190-kDa抗原循环性自身抗体的形成

Drug rash with eosinophilia and systemic symptoms induced by valproate and carbamazepine : Formation of circulating autoantibody against 190-kDa antigen

研究组在原有抗精神病药治疗的同时加用丙戊酸镁治疗，起始剂量400mg·d-1,1w后增至800mg～1200mg·d-1；对照组继续原有抗精神病药治疗。

Research group were given anti-psychotics combined with magnesium valproate , its beginning dosage was 400mg / d and reached 800 ~ 1200mg / d after one week , and control group with single anti-psychotics for 4 weeks .

因为可疑为药物引起的肺嗜酸细胞增多症，丙戊酸被停用。

Drug-induced pulmonary eosinophilia was suspected and valproic acid was discontinued .

同时在发展中国家，丙戊酸镁也应该作为首选。

In developing countries , VPA-Mg should be the first choice .

丙戊酸镁治疗癫痫1911例临床疗效

The efficacy of magnesium valproate in the 1911 cases with epilepsy

丙戊酸镁和碳酸锂治疗躁狂症对照研究

A control study about valproate magnesium and lithium carbonate for mania

小分子化合物丙戊酸促进大鼠坐骨神经再生的研究

Valproic Acid Enhances Axonal Regeneration after Sciatic Nerve Axotomy in Adult Rats

同样的情况适用于氟哌啶醇氯丙嗪和丙戊酸

The same goes for Haldol , Thorazine and valproic acid

丙戊酸对癫痫病人血清胰岛素及瘦素水平的影响

Influence of valproate acid on insulin and leptin levels in epileptic patients

稳态试验丙戊酸镁缓释片人体生物利用度的研究

Study on Biological Availability of Magnesium Valprote Extended Action Tablet

妊娠期服用丙戊酸盐使子代的主要畸形率增加

Increased rate of major malformations in offspring exposed to valproate during pregnancy

丙戊酸抑制血管紧张素Ⅱ致大鼠心肌细胞肥大

Valproic acid inhibits the cardiomyocyte hypertrophy induced by angiotensin ⅱ in rats

丙戊酸诱导胎鼠发生隐性脊椎裂畸形的模型建立

Model of spina bifida occulta induced by valproic acid in foetal rats

血清中丙戊酸镁浓度的气相色谱测定法

Determination of Magnesium Valproate in Serum by Gas Chromatography

贝叶斯法估算丙戊酸药动学参数及个体化给药

Estimation of pharmacokinetics parameter of valproic acid and administration with individuation by bayesian

儿童丙戊酸血药浓度与给药剂量

The relation between valproic acid dosage and serum concentration in children with epilepsy

丙戊酸盐的神经保护作用及其机制的研究进展

Neuroprotective Actions and Possible Underlying Molecular Mechanisms of Valproate

游离丙戊酸血清药物浓度的测定

Determination of free valproic acid in human serum