丙硫氧嘧啶

甲巯咪唑与丙硫氧嘧啶对Graves甲亢疗效的再评价丙硫氧嘧啶的严重不良反应及药学监护要点

Reevaluation of the Effects of Methimazole and Propylthiouracil in Patients with Graves Hyperthyrodism ; Side Effects Propylthiouracil and Key Points in Pharmaceutical Care of Patients Receiving Propylthiouracil

目的探讨服用抗甲状腺药[丙硫氧嘧啶（PTU）、甲巯咪唑（MMI）]致急进性肾小球肾炎（RPGN）的临床特征。

Objective To explore the clinical characteristic of rapidly progressive glomerulonephritis ( RPGN ) induced by the antithyroid agents [ propylthiouracil ( PTU ) and methimazole ( MMI ) ] .

目的：提高临床对丙硫氧嘧啶（PTU）引起抗中性粒细胞胞浆抗体（ANCA）相关小血管炎的认识。

Objective : To improve the knowledge on propythiouracil ( PTU ) - induced antineutrophil cytoplasmic antibody ( ANCA ) - associated vasculitis .

结果苯巴比妥组和苯巴比妥加丙硫氧嘧啶组游离甲状腺素较对照组明显降低（P<0.01），促甲状腺激素显著增高（P<0.01），GFAP免疫反应显著减弱（P<0.01）。

Results Compared with the control group , phenobarbital meal group , phenobarbital and propylthiouracil meal group had lower free thyroid hormones ( P < 0.01 ), higher TSH ( P < 0 . 01 ), weaker immunoreaction of GFAP ( P < 0 . 01 ) .

[目的]研究丙硫氧嘧啶（propylthiouracil，PTU）致甲状腺增生的量效关系，为以PTU为模型药物的甲状腺激素干扰物体内短期甄别方法体系的建立提供实验室依据。

[ Objective ] To study the effect of PTU on thyroid function in rats , and the quantity-effect relationship and provide the data for the method of assessment for thyroid hormone disruptors in vivo within short time with PTU as model .

丙硫氧嘧啶胃内滞溜片的含量及释放度测定

Assay of content and release degree of propylthiouracil stomach - retained tablet

目的：建立测定丙硫氧嘧啶片含量的方法。

Objective : To establish the method for determination of Propylthiouracil Tablets .

丙硫氧嘧啶肠溶胶囊人体相对生物利用度研究

Study on the Relative Bioavailability of Propylthiouracil Enteric Coated Capsules

丙硫氧嘧啶致急性肾衰死亡尸检呈紫癜肾

Death from acute renal failure caused by propylthiouracil showing purpura kidneys at autopsy

结果：1、丙硫氧嘧啶可诱发小鼠甲状腺肿。

Propylthiouracil could cause Goiter of mice . 2 .

丙硫氧嘧啶致甲状腺组织增生的时效关系研究

Time-effect study of propylthiouracil-induced thyroid gland hyperplasia

抗内皮细胞抗体与丙硫氧嘧啶引起的抗中性粒细胞胞浆抗体阳性小血管炎病变活动相关

Anti-endothelial cell antibodies ( AECA ) are associated with disease activity of propylthiouracil induced antineutrophil cytoplasmic antibody ( ANCA ) positive vasculitis