甲状腺增生

但对滤泡性癌与滤泡性腺瘤之间的诊断与鉴别诊断帮助不大；CK19、TPO、Galectin3联合检测有助于提高甲状腺增生性病变的诊断准确率。

Combination of CK19 , TPO , Galectin-3 can improve the rate of correct diagnosis in thyroid lesions of malignant and benign hyperplasia .

[结论]叶枯宁对大鼠血清FT4和TSH水平的影响发生在5d之内，并可继发引起甲状腺增生。

[ Conclusion ] The effect of YE KU NING on the level of serum FT4 and TSH in rats occurs within 5 days and may be followed by the consequent hyperplasia of thyroid gland .

[结论]选择甲状腺增生的组织学早期改变为实验观察敏感性终点，建立以PTU为模型药物的甲状腺激素干扰物体内短期甄别方法体系是可行的。

[ Conclusions ] Selecting the early histopathological change as the end points , the method of assessment for thyroid hormone disruptors in vivo within short time is feasible .

[目的]研究丙硫氧嘧啶（propylthiouracil，PTU）致甲状腺增生的量效关系，为以PTU为模型药物的甲状腺激素干扰物体内短期甄别方法体系的建立提供实验室依据。

[ Objective ] To study the effect of PTU on thyroid function in rats , and the quantity-effect relationship and provide the data for the method of assessment for thyroid hormone disruptors in vivo within short time with PTU as model .

本研究为临床寻找新的甲状腺增生性疾病治疗靶点提供了重要依据。

Conclusion The expression of ER and PR in thyroid cancer might be used as the markers to evaluate prognosis and provide new therapeutic targets in hyperplastic diseases therapy .

丙硫氧嘧啶致甲状腺组织增生的时效关系研究

Time-effect study of propylthiouracil-induced thyroid gland hyperplasia

Ki-67在甲状腺滤泡性增生结节良性组与恶性组中的表达指数分别为2.49±1.98和8.98±9.24，两组比较差异有统计学意义（P0.001）。

The expression indexes of Ki-67 in benign and malignant group were 2.49 ± 1.98 and 8.98 ± 9.24 , respectively and there was also a significant difference between benign and malignant group ( P 0.001 ) .

56例甲状腺乳头状增生性病变的回顾性研究

Retrospective study of 56 cases of papillary hyperplasia of thyroid gland

收集56例甲状腺乳头状增生性病变的临床病理资料，试图进一步探讨此类病变形态学各个方面与患者预后的关系。

Fifty-six cases of papillary hyperplasia of thyroid gland were reexamined by means of routine HE staining and light microscope in order to study the relationship between the morphology of some papillary hyperplasia and the prognosis of patients .

三种外源凝集素对三种癌的阳性结合率基本是乳头状癌高于滤泡癌，滤泡癌高于未分化癌、腺瘤和结节性甲状腺肿有乳头增生者阳性率高于未增生者；

Positive incidence of thyroid adenomas and nodular goiters with papillary proliferation were higher than in those without papillary proliferation .

氟化物导致甲状腺滤泡旁细胞增生及损伤是氟导致甲状腺肿的机理之一。

Fluoride could seriously damage the structure of parafollicular cell and cause the hyperplastic nodule made of parafollicular cells which led to the goiter .

结果结节性甲状腺肿伴非典型增生为6.9%（35/508），其中轻度非典型增生占6.1%（31/508），重度非典型增生占0.8%（4/508）。

Results Nodular goiters with atypical hyperplasia were 6.9 % ( 35 / 508 ), among them slight atypical hyperplasias were 6.1 % ( 31 / 508 ) and severe atypical hyperplasias were 0.8 % ( 4 / 508 ) .

结论高碘饮用水可引起实验动物呈剂量反应的甲状腺病理组织改变，甲状腺增生、胶质代谢障碍、毛细血管扩张及间质水肿为其主要表现。

Conclusions Drinking water with excess iodine can induce pathological change of thyroid of experimental animals , which presents dose response relation . The manifestation is thyroid accrementition , dysbolism of colloid , angiotelectasis and interstitial edema .

CK-19在甲状腺乳头状癌及甲状腺乳头状增生患者外周血中的表达

Expression of CK-19 in peripheral blood of patients with papillary thyroid carcinoma and papillary thyroid hyperplasia

病理显示甲减模型大鼠甲状腺外观明显肿大，光镜下见甲状腺组织代偿性增生。

Model rats pathology revealed thyroid appearance , then obviously enlargement under compensatory sex hyperplasia see thyroid organization .

观察了饮用高氟水及加硒大鼠的甲状腺组织结构和甲状腺激素变化。结果表明，早期甲状腺滤泡上皮细胞增生活跃、游离甲状腺激素水平显著升高；

Thyroid tissue structure and thyroid hormones of rats with drinking high fluoride ( F ) water and feeding selenium ( Se ) feed were observed to study the effects of high F and supplied Se on thyroid .

淋巴滤泡瘤样增生与滤泡性淋巴瘤鉴别诊断高碘甲状腺肿是由于滤泡扩张，过多胶质堆积在滤胞腔内所致，并非TSH升高导致甲状腺滤泡增生的结果。

Differential diagnosis between follicular lymphoma and tumor-like follicular hyperplasia Iodide goiter was not due to elevation of TSH level to induce the thyroid follicular hyperplasia .